Long non-coding RNA UCA1 upregulation promotes the migration of hypoxia-resistant gastric cancer cells through the miR-7-5p/EGFR axis

Yang, Zichang; Shi, Xiaonan; Li, Ce; Wang, Xiaoxun; Hou, Kezuo; Li, Zhi; Zhang, Xiaojie; Fan, Yibo; Qu, Xiujuan; Che, Xiaofang; Liu, Yunpeng

doi:10.1016/j.yexcr.2018.04.030

Cited by 50 publications

(34 citation statements)

References 35 publications

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“…Due to the discovery more novel important functions of non-coding RNAs (ncRNAs) including miRNAs, LncRNAs, and circRNAs, participating in tumor progression, we pay special attention in the present work to the role of hypoxia microenvironment-related ncRNAs in GC. In our previous study, we established HRGC cell lines to stimulate the real situation of a long-term hypoxic microenvironment, and found that LncRNA UCA1 was upregulated and promoted the migration of GC cells through the miR-7-5p/EGFR axis under a long-term hypoxic microenvironment (14). However, the biological functions of another subtype of ncRNAs-circRNAs involved in long-term hypoxia-promoting metastatic process of GC remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Jin

Che

et al. 2020

Front. Oncol.

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Section: Introductionmentioning

confidence: 99%

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Jin

Che

et al. 2020

Front. Oncol.

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“…UCA1 could significantly promote cell migration and inhibit apoptosis in GC cell lines SUN-216 and SGC-7091 via inhibition of miR-182, whose downstream target is tissue inhibitors of metalloproteinase 2 (TIMP2) [63]. Similarly, UCA1 enhanced the invasion of GC by directly interacting with miR-203 or miR-7-5p, increasing the release of miR-203-targeted transcripts zinc finger E-box-binding homeobox2 (ZEB2) or miR-7-5p-targeted epidermal growth factor receptor (EGFR), respectively [64,65]. Moreover, UCA1 also could promote the proliferation and invasion of GC through sponging miR-495-3p [30].…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Xuan

Zhang

et al. 2019

FEBS Letters

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Long non-coding RNAs (lncRNAs) are a major subset of highly conserved non-coding RNAs (ncRNAs) that consist of at least 200 nucleotides and have limited protein-coding potential. Cumulative data have shown that lncRNAs are deregulated in many types of cancer and may control pathophysiological processes of cancer at various levels, including transcription, post-transcription and translation. Recently, lncRNAs have been demonstrated to interact with microRNAs (miRNAs), another major subset of ncRNAs, which regulate physiological and pathological processes by inhibiting target mRNA translation or promoting mRNA degradation. The lncRNA urothelial carcinomaassociated 1 (UCA1) has recently gained much attention as it is overexpressed in many types of cancer and is involved in carcinogenesis. Here, we review the crosstalk between UCA1 and miRNAs during the pathogenesis of cancer, with a focus on cancer-cell proliferation, invasion, drug resistance, and metabolism.

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“…miR-7 has been found in recent years to serve as a tumor suppressor in several tumor types, but its role in GC has not previously been demonstrated. Recent reports showed that miR-7 plays a certain role in gastric cancer and can be regulated by Circular RNA, long non-coding RNA or DNA methylation (Pan et al, 2018;Yang et al, 2018;Xin et al, 2020). Herein, we found miR-7 to be expressed at lower levels in GC tumors, and when overexpressed miR-7 inhibited the proliferation and glycolytic metabolism of GC cells, in addition to increasing their cisplatin sensitivity.…”

Section: Discussionmentioning

confidence: 65%

Down-Regulation of miR-7 in Gastric Cancer Is Associated With Elevated LDH-A Expression and Chemoresistance to Cisplatin

Jin

Wang

Shao

et al. 2020

Front. Cell Dev. Biol.

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MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer (GC), and we further determined its expression to be closely linked to GC sensitivity to the chemotherapeutic compound cisplatin. This effect appears to be at least partially attributable to the regulation of LDH-A, which is a miR-7 target gene and expression of LDH-A is negatively correlated with miR-7 expression in primary GC tumor samples. When upregulated, we also determined that miR-7 was able to inhibit the proliferation, colony formation, and glycolysis of GC cells owing to its regulation of LDH-A. Moreover, overexpression of miR-7 render cells more sensitive to cisplatin. Our results thus provide novel evidence that miR-7 is a key mediator of GC growth and chemosensitivity through its regulation of LDH-A, thus potentially highlighting this pathway as a therapeutic target for treating affected patients.

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Long non-coding RNA UCA1 upregulation promotes the migration of hypoxia-resistant gastric cancer cells through the miR-7-5p/EGFR axis

Cited by 50 publications

References 35 publications

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Down-Regulation of miR-7 in Gastric Cancer Is Associated With Elevated LDH-A Expression and Chemoresistance to Cisplatin

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