Quantitative measurement of cartilage volume is possible using two-dimensional magnetic resonance imaging data sets

Schaefer, L.F.; Nikac, Violeta; Lynch, J.A.; Duryea, J.

doi:10.1016/j.joca.2018.04.005

Cited by 7 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The subset was chosen randomly for prior MRI measurement methodology development and was designed to follow the case and control distributions of the full FNIH sample [ 38 ]. The FNIH subset included radiographic and pain progressors (n = 97), radiographic-only progressors (n = 52), pain-only progressors (n = 52), and non-progressors (n = 100) (we had access to the raw data from this study) [ 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

Gilles

Vohra

Robles

et al. 2023

JCM

View full text Add to dashboard Cite

Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren–Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans blinded to prior assessments. The estimated intraclass correlation coefficient (ICC) for intra-reader reliability of the single-slice ES method in the KL 2–3 sample was 0.96 (95% CI: 0.93, 0.97), and for inter-reader reliability, the ICC was 0.90 (95% CI: 0.87, 0.95). The intra-reader mean absolute difference (MAD) was 35 mm3 (95% CI: 28, 44), and the inter-reader MAD was 61 mm3 (95% CI: 48, 76). Our single-slice quantitative knee ES measurement offers a reliable, valid, and efficient surrogate for multi-slice quantitative and semi-quantitative assessment.

show abstract

Section: Methodsmentioning

confidence: 99%

Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

Gilles

Vohra

Robles

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…The FNIH study divided the participants into 4 groups based on pain and/or radiographic progression. Following the design of a previous study [ 23 ], we randomly selected 301 of the 600 FNIH participants such that the proportion for each group matched the main study as closely as possible. The 301 subjects were distributed as follows: Group 1: radiographic and pain progressors (n = 97), Group 2: radiographic-only progressors (n = 52), Group 3: pain-only progressors (n = 52), Group 4: no radiographic or pain progressors (n = 100).…”

Section: Methodsmentioning

confidence: 99%

Association of quantitative measures of effusion-synovitis and hoffa-synovitis with radiographic and pain progression: Data from the FNIH OA biomarkers consortium

Smith

Hosseinzadeh

Maetani

et al. 2021

Osteoarthritis and Cartilage Open

View full text Add to dashboard Cite

Cartilage Topography Assessment With Local‐Area Cartilage Segmentation for Knee Magnetic Resonance Imaging

Mathiessen

Ashbeck

Huang

et al. 2022

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. Local-area cartilage segmentation (LACS) software was developed to segment medial femur (MF) cartilage on magnetic resonance imaging (MRI). Our objectives were 1) to extend LACS to the lateral femur (LF), medial tibia (MT), and lateral tibia (LT), 2) to compare LACS to an established manual segmentation method, and 3) to visualize cartilage responsiveness over each cartilage plate.Methods. Osteoarthritis Initiative participants with symptomatic knee osteoarthritis (OA) were selected, including knees selected at random (n = 40) and knees identified with loss of cartilage based on manual segmentation (Chondrometrics GmbH), an enriched sample of 126 knees. LACS was used to segment cartilage in the MF, LF, MT, and LT on sagittal 3D double-echo steady-state MRI scans at baseline and at 2-year follow-up. We compared LACS and Chondrometrics average thickness measures by estimating the correlation in each cartilage plate and estimating the standardized response mean (SRM) for 2-year cartilage change. We illustrated cartilage loss topographically with SRM heatmaps.Results. The estimated correlation between LACS and Chondrometrics measures was r = 0.91 (95% confidence interval [95% CI] 0.86, 0.94) for LF, r = 0.93 (95% CI 0.89, 0.95) for MF, r = 0.97 (95% CI 0.96, 0.98) for LT, and r = 0.87 (95% CI 0.81, 0.91) for MT. Estimated SRMs for LACS and Chondrometrics measures were similar in the random sample, and SRM heatmaps identified subregions of LACS-measured cartilage loss.Conclusion. LACS cartilage thickness measurement in the MF and LF and tibia correlated well with established manual segmentation-based measurement, with similar responsiveness to change, among knees with symptomatic knee OA. LACS measurement of cartilage plate topography enables spatiotemporal analysis of cartilage loss in future knee OA studies.

show abstract

Quantitative measurement of cartilage volume is possible using two-dimensional magnetic resonance imaging data sets

Abstract: This study has demonstrated that a reproducible, responsive, and clinically valid quantitative measurement of cartilage volume can be made using 2D TSE scans with a modest loss of responsiveness compared to 3D scans.

Cited by 7 publications

References 14 publications

Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

Association of quantitative measures of effusion-synovitis and hoffa-synovitis with radiographic and pain progression: Data from the FNIH OA biomarkers consortium

Cartilage Topography Assessment With Local‐Area Cartilage Segmentation for Knee Magnetic Resonance Imaging

Contact Info

Product

Resources

About