A 10-year longitudinal follow-up study of a U.K. paediatric transplant population to assess for skin cancer

Foo, S.H.; Gazzani, P.; Bader, E.; Ogboli, Malobi; Martín-Clavijo, Agustín; Milford, David V.; Kelly, Déirdre; Moss, Celia; Thomson, Maurine

doi:10.1111/bjd.16697

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…There are reports of this same trend in pediatric SOTR. 98 Of note, some studies of pediatric SOTR report no incident skin cancers, but the length of follow-up 99,100 and attrition from the initial cohort 100 limits broad conclusions from these studies. Importantly, the development of skin cancer after pediatric transplantation typically occurs several years after transplant ( Figure 2); reported time to onset ranges widely, with averages at 6 to 20 years post-transplant.…”

Section: Skin Cancer After Organ Transplantmentioning

confidence: 99%

Post‐transplant malignancies in pediatric organ transplant recipients

Robinson

Coughlin

Chanchlani

et al. 2020

Pediatric Transplantation

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The majority of cancer diagnoses in pediatric solid organ transplant recipients (SOTRs) are post‐transplantation lymphoproliferative disorders (PTLD) or skin cancers. However, pediatric SOTRs are also at significantly elevated risk for multiple other solid and hematological cancers. The risks of specific cancers vary by transplanted organ, underlying disease, and immunosuppression factors. More than one‐quarter of pediatric SOTRs develop cancer within 30 years of transplantation and their risk of solid cancer is 14 times greater than the general population. Pediatric SOTRs are at significantly higher risk of cancer‐associated death. Improving patient survival among pediatric SOTRs puts them at risk of adult epithelial cancers associated with environmental carcinogenic exposures. Vaccination against oncogenic viruses and avoidance of excessive immunosuppression may reduce the risk of solid cancers following transplantation. Patient and family education regarding photoprotection is an essential component of skin cancer prevention. There is significant variability in cancer screening recommendations for SOTRs and general population approaches are typically not validated for transplant populations. An individualized approach to cancer screening should be developed based on estimated cancer risk, patient life expectancy, and screening test performance.

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Section: Skin Cancer After Organ Transplantmentioning

confidence: 99%

Post‐transplant malignancies in pediatric organ transplant recipients

Robinson

Coughlin

Chanchlani

et al. 2020

Pediatric Transplantation

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show abstract

“…Thus, longitudinal outcomes data for comorbidities is ever more important. In this issue of the BJD , Foo et al . present a 10‐year follow‐up of a cohort of POTRs initially reported in a study of paediatric renal and liver transplant recipients 5–16 years post‐transplant .…”

mentioning

confidence: 99%