Treatment modalities for burning mouth syndrome: a systematic review

Souza, Isadora Follak De; Mármora, Belkiss Câmara; Rados, Pantelis Varvaki; Visioli, Fernanda

doi:10.1007/s00784-018-2454-6

Cited by 42 publications

(53 citation statements)

References 42 publications

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“…Burning mouth syndrome has long been studied and many therapeutic modalities have been evaluated. However, to date, consensus on the standard for its management does not exist (de Souza et al., ). A recent Cochrane review confirmed the lack of RCTs that provide sufficient guidance to clinicians on effective treatment interventions (McMillan et al., ).…”

Section: Discussionmentioning

confidence: 99%

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

et al. 2019

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Objective To conduct a systematic review analyzing disease definitions and diagnostic criteria used in randomized controlled trials (RCTs) involving burning mouth syndrome (BMS). Methods A systematic search conducted in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar that included RCTs on BMS published between 1994 and 2017 was performed. Results Considerable variability in BMS disease definitions and diagnostic criteria used created substantial heterogeneity in the selection of participants and weakened the rigor of the 36 RCTs identified. The analyzed RCTs routinely under‐reported the methods used to rule in or out study participants and the number of individuals excluded from BMS RCTs. Conclusions Our findings indicate that a large proportion of participants enrolled in these studies may have had an underlying condition that could have explained their BMS symptoms. Thus, outcomes of therapeutic interventions from these BMS RCTs should be interpreted with caution due to heterogeneous disease definitions and diagnostic criteria. In order to improve the quality of clinical trials, future research should focus on establishing consensus for a single definition of BMS that includes specific inclusion and exclusion criteria that should be used to select study participants for clinical trials.

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Section: Discussionmentioning

confidence: 99%

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

et al. 2019

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“…However, their use in orofacial pain research has been limited (Chen & Lee, ; Haythornthwaite, ) and the utilization in BMS RCTs has not been assessed. Consequently, standardization in the reporting of outcomes in BMS RCTs is lacking, and despite the large number of RCTs published in this field, systematic reviews have been unable to draw conclusive results and provide strong recommendations (Coculescu, Manole, Coculescu, & Purcarea, ; Hakeem, Fitzpatrick, Bhattacharyya, Islam, & Cohen, ; McMillan et al, ; Patton et al, ; de Souza et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, standardization in the reporting of outcomes in BMS RCTs is lacking, and despite the large number of RCTs published in this field, systematic reviews have been unable to draw conclusive results and provide strong recommendations (Coculescu, Manole, Coculescu, & Purcarea, 2015;Hakeem, Fitzpatrick, Bhattacharyya, Islam, & Cohen, 2018;McMillan et al, 2016;Patton et al, 2007;de Souza et al, 2018). To the authors' knowledge, this is the first investigation to systematically assess the reporting of outcome measures in BMS RCTs and the adherence to the IMMPACT core domains and their recommended tools of assessment (Dworkin et al, 2005;Turk et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

World Workshop in Oral Medicine VII: Reporting of IMMPACT‐recommended outcome domains in randomized controlled trials of burning mouth syndrome: A systematic review

et al. 2019

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Objectives To determine the frequency of use of the core outcome domains published by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) in burning mouth syndrome (BMS) randomized controlled trials (RCTs). Methods This systematic review, conducted as part of the World Workshop on Oral Medicine VII (WWOM VII), was performed by searching the literature for studies published in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar from January 1994 (when the first BMS definition came out) through October 2017. Results A total of 36 RCTs (n = 2,175 study participants) were included and analyzed. The overall reporting of the IMMPACT core and supplemental outcome domains was low even after the publication of the IMMPACT consensus papers in 2003 and 2005 (mean before IMMPACT consensus publication = 2.6 out of 6; mean after IMMPACT publication = 3.8 out of 6). Use of validated assessment tools recommended by the IMMPACT consensus was scarce (1.9 out of 6). None of the RCTs reviewed cited the IMMPACT consensus papers. Conclusions The underreporting of IMMPACT outcome domains in BMS RCTs is significant. Raising awareness regarding the existence of standardized outcome domains in chronic pain research is essential to ensure more accurate, comparable, and consistent interpretation of RCT findings that can be clinically translatable.

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“…Many papers have considered anxiolytics to be the gold standard treatment of BMS, but clinicians are aware that very often people with BMS present for their first visit complaining of oral burning sensation when they are already receiving anxiolytic medication (Schiavone et al, ; de Souza, Mármora, Rados, & Visioli, ).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown how BMS could be related to central sensitization of an independent nociceptive pathway that might affect the GABAergic activity of the trigeminal nerve (Tan, Song, Dong, Somvanshi, & Cairns, 2014 Many papers have considered anxiolytics to be the gold standard treatment of BMS, but clinicians are aware that very often people with BMS present for their first visit complaining of oral burning sensation when they are already receiving anxiolytic medication (Schiavone et al, 2012;de Souza, Mármora, Rados, & Visioli, 2018).…”

Section: Frequency Of Distributionmentioning

confidence: 99%

Is there an association between drugs and burning mouth syndrome? A case–control study

et al. 2019

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Objective The purpose of this case–control study was to compare the pharmacological anamnesis collected from a group of 150 burning mouth syndrome (BMS) patients with that of a control group of 150 patients matched for age and sex. Materials and Methods The patients' medical histories were reviewed, and data on drug therapy were collected. Drugs were classified on the basis of pharmacological effects; the classes were antihypertensives (i.e., ACE inhibitors/ARBs, calcium antagonists, diuretics and beta‐blockers), antiaggregants, anticoagulants, antidiabetics, vitamin D integrators, bisphosphonates, psychotropics (i.e., anxiolytics and antidepressants), gastroprotectors, statins, thyroid hormone substitutes, corticosteroids and immunosuppressants. Results The BMS patients and the controls were matched for age (mean age: 69 years) and sex (128 females and 22 males). Antihypertensives, especially ACE inhibitors/ARBs (OR = 0.37, CI: 0.22–0.63, p = 0.0002) and beta‐blockers (OR = 0.36, CI: 0.19–0.68 p = 002), revealed an inverse association with the presence of BMS, whereas anxiolytics (OR = 3.78, CI: 2.12–6.75 p < 0.0001), but neither antidepressants nor antipsychotics, were significantly associated with BMS. There were no correlations with other drug classes. Conclusion Our study highlighted that ACE inhibitors, ARBs and beta‐blockers were in inverse relation to BMS and found that anxiolytics, but neither antidepressants nor antipsychotics, were linked to the presence of the syndrome.

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Treatment modalities for burning mouth syndrome: a systematic review

Abstract: To review systematically the literature about Burning Mouth Syndrome treatment may aid the clinicians to choose the treatment modality to improve patients symptoms based on the best evidence.

Cited by 42 publications

References 42 publications

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

World Workshop in Oral Medicine VII: Reporting of IMMPACT‐recommended outcome domains in randomized controlled trials of burning mouth syndrome: A systematic review

Is there an association between drugs and burning mouth syndrome? A case–control study

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