Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction

Pleet, Michelle L.; Mathiesen, Allison; DeMarino, Catherine; Akpamagbo, Yao; Barclay, Robert A.; Schwab, Angela; Iordanskiy, Sergey; Sampey, Gavin C.; Lepene, Benjamin; Ilinykh, Philipp A.; Bukreyev, Alexander; Nekhai, Sergeï; Aman, M. Javad; Kashanchi, Fatah

doi:10.3389/fmicb.2018.00692

Cited by 2 publications

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“…Upon infection, EBOV primarily targets dendritic cells, monocytes, and macrophages, potentially facilitating systemic virus spread, including liver and secondary lymphoid organs [ 40 ]. Given the symptoms mentioned above and the high mortality rate of 80–90%, Ebola patients’ rapid identification is necessary [ 41 ]. A commonly applied technique for diagnosing Ebola patients is the detection of VP40, the EBOV matrix protein [ 39 ].…”

Section: Role Of Evs In the Pathogenesis Of Viral Infectionsmentioning

confidence: 99%

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Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans

Caobi

Nair

Raymond

2020

Viruses

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Most cells can release extracellular vesicles (EVs), membrane vesicles containing various proteins, nucleic acids, enzymes, and signaling molecules. The exchange of EVs between cells facilitates intercellular communication, amplification of cellular responses, immune response modulation, and perhaps alterations in viral pathogenicity. EVs serve a dual role in inhibiting or enhancing viral infection and pathogenesis. This review examines the current literature on EVs to explore the complex role of EVs in the enhancement, inhibition, and potential use as a nanotherapeutic against clinically relevant viruses, focusing on neurotropic viruses: Zika virus (ZIKV) and human immunodeficiency virus (HIV). Overall, this review's scope will elaborate on EV-based mechanisms, which impact viral pathogenicity, facilitate viral spread, and modulate antiviral immune responses.

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Section: Role Of Evs In the Pathogenesis Of Viral Infectionsmentioning

confidence: 99%

“…EBOV pathology is further enhanced by exosome-bound VP40 modulating RNAi components, such as Dicer and Ago 1, and inducing recipient naïve cell death while upregulating exosome biogenesis [ 41 ]. EBOV content release is not limited to exosomes but extends to microvesicles as well [ 38 ].…”

Section: Role Of Evs In the Pathogenesis Of Viral Infectionsmentioning

confidence: 99%

Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans

Caobi

Nair

Raymond

2020

Viruses

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A Comprehensive Insight into the Role of Exosomes in Viral Infection: Dual Faces Bearing Different Functions

et al. 2021

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Extracellular vesicles (EVs) subtype, exosome is an extracellular nano-vesicle that sheds from cells’ surface and originates as intraluminal vesicles during endocytosis. Firstly, it was thought to be a way for the cell to get rid of unwanted materials as it loaded selectively with a variety of cellular molecules, including RNAs, proteins, and lipids. However, it has been found to play a crucial role in several biological processes such as immune modulation, cellular communication, and their role as vehicles to transport biologically active molecules. The latest discoveries have revealed that many viruses export their viral elements within cellular factors using exosomes. Hijacking the exosomal pathway by viruses influences downstream processes such as viral propagation and cellular immunity and modulates the cellular microenvironment. In this manuscript, we reviewed exosomes biogenesis and their role in the immune response to viral infection. In addition, we provided a summary of how some pathogenic viruses hijacked this normal physiological process. Viral components are harbored in exosomes and the role of these exosomes in viral infection is discussed. Understanding the nature of exosomes and their role in viral infections is fundamental for future development for them to be used as a vaccine or as a non-classical therapeutic strategy to control several viral infections.

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Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction

Cited by 2 publications

References 1 publication

Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans

Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans

A Comprehensive Insight into the Role of Exosomes in Viral Infection: Dual Faces Bearing Different Functions

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