Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration

Maestrelli, Francesca; Jug, Mario; Cirri, Marzia; Kosalec, Ivan; Mura, Paola

doi:10.1016/j.carbpol.2018.03.054

Cited by 36 publications

(16 citation statements)

References 35 publications

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“…The particle sizes were consistent in the range 200 to 300nm with polydispersity index or particle size distribution less than 0.8 indicating good results ( Table 5 and Figure 9). 27 Scanning Electron Microscopy: SEM image of cefixime nanoparticles shown in Figure 10 concludes that nanoparticles are found in nano size. Transmission Electron Microscopy: TEM cefixime nanoparticles in Figure 11; TEM image of optimized cefixime nanosuspension shows spherical size of the nanoparticles.…”

Section: Particle Size Analysis and Polydispersity Indexmentioning

confidence: 94%

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Mastiholimath¹,

Rajendra²,

Mannur³

et al. 2019

IJPER

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Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol and Millipore water was used as solvent and antisolvent respectively. The surfactants used for the preparation were PVP K30 and HPMC K100 which was found to be compatible in the formulation. Compatibility of the drug and drug with its excipients was found out by FTIR studies. Characterization of the optimized Cefixime Nanosuspension was carried out by particle size analysis, Differential Scanning Calorimetry, Zeta Potential, Drug content, in-vitro drug release studies, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy(TEM). The antimicrobial activity of cefixime nanosuspension was done by Disk diffusion method against E. coli performed in nutrient agar with different concentrations of the formulation. The Minimum Inhibitory Concentration (MIC) was determined by calculating Zone of inhibition. A method was developed forcefixime nanosuspension and validated by High Performance Thin Layer Chromatography (HPTLC). Results: The optimizedcefixime nanosuspension was validated for Identification, Linearity, Specificity, Precision and Recovery. The Recovery of cefixime nanosuspension was found to be 95.57%.

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Section: Particle Size Analysis and Polydispersity Indexmentioning

confidence: 94%

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Mastiholimath¹,

Rajendra²,

Mannur³

et al. 2019

IJPER

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“…Another example of multiparticulate systems is represented by chitosan-alginate microspheres such as those formulated by Maestrelli et al (2018) for the vaginal administration of cefixime, used in order to overcome drawbacks following its oral administration. The effect of increasing drug loading amount was investigated; mucoadhesion studies reported that all formulations were able to remain in situ for more than 2 h (on excised porcine vaginal mucosa), showing good adhesion properties.…”

Section: Bacterial Vaginosismentioning

confidence: 99%

“…Microbiological studies confirmed the potential advantages of such systems that can be administered inside a capsule by a commercially available vaginal applicator. After capsule dissolution, the distribution of chitosan-alginate microspheres occurs with a prolonged in situ activity of cefixime due to their good mucoadhesion and extended release properties [45].…”

Section: Bacterial Vaginosismentioning

confidence: 99%

Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials

et al. 2021

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Vaginal infections such as bacterial vaginosis (BV), chlamydia, gonorrhea, genital herpes, candidiasis, and trichomoniasis affect millions of women each year. They are caused by an overgrowth of microorganisms, generally sexually transmitted, which in turn can be favored by alterations in the vaginal flora. Conventional treatments of these infections consist in systemic or local antimicrobial therapies. However, in the attempt to reduce adverse effects and to contrast microbial resistance and infection recurrences, many efforts have been devoted to the development of vaginal systems for the local delivery of antimicrobials. Several topical dosage forms such as aerosols, lotions, suppositories, tablets, gels, and creams have been proposed, although they are sometimes ineffective due to their poor penetration and rapid removal from the vaginal canal. For these reasons, the development of innovative drug delivery systems, able to remain in situ and release active agents for a prolonged period, is becoming more and more important. Among all, nanosystems such as liposomes, nanoparticles (NPs), and micelles with tunable surface properties, but also thermogelling nanocomposites, could be exploited to improve local drug delivery, biodistribution, retention, and uptake in vulvovaginal tissues. The aim of this review is to provide a survey of the variety of nanoplatforms developed for the vaginal delivery of antimicrobial agents. A concise summary of the most common vaginal infections and of the conventional therapies is also provided.

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“…[5] Natural polymers are good candidates for drug carriers due to their excellent biocompatibility and biodegradability. [6][7][8] Chitosan is a natural linear polyaminosaccharide obtained by alkaline deacetylation of chitin, which is the second most abundant polysaccharide, next to cellulose. [9] Because of its biocompatibility, nontoxicity, and antibacterial properties, it is a very attractive biomaterial to be used as a drug carrier.…”

Section: Doi: 101002/macp202100027mentioning

confidence: 99%

Increased Stability of Polysaccharide/Silica Hybrid Sub‐Millicarriers for Retarded Release of Hydrophilic Substances

Elzayat

Tolba

Pérez-Plá

et al. 2021

Macro Chemistry & Physics

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This work reports an in situ strategy for the synthesis of hybrid sub‐millispheres as carriers for encapsulating and controlling the release of hydrophilic pharmaceutical compounds in both neutral and acidic media. An organic–inorganic hydrogel is prepared by ionotropic gelation, and its efficiency for entrapping hydrophilic molecules is investigated. Two biopolymers, namely chitosan or alginate, are used to generate a scaffold network, in which the formation of silica nanoparticles takes place in situ by a sol–gel process. Model hydrophilic molecules (erioglaucine disodium salt and ephedrine hydrochloride) are encapsulated within polymer matrix, and the subsequent release is controlled by tailoring the hybrid network structure. Kinetic studies demonstrate that the release of the active substance is slower in the presence of silica, which increases as well the structural stability of the carrier in both neutral and acidic media. As a result, by incorporating nanostructured silica into the polymer matrix, the presented system overcomes the limitations of the ionotropic method for entrapping hydrophilic substances.

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Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration

Cited by 36 publications

References 35 publications

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials

Increased Stability of Polysaccharide/Silica Hybrid Sub‐Millicarriers for Retarded Release of Hydrophilic Substances

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