First case of AML with rare chromosome translocations: a case report of twins

Wang, Lin; Sun, Yihong; Sun, Ying; Meng, Lingbin; Xu, Xin

doi:10.1186/s12885-018-4396-4

Cited by 9 publications

(7 citation statements)

References 14 publications

(11 reference statements)

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“…Some authors have reported that ubiquitin specific peptidase 9, Y-linked (USP9Y)– TTTY15 is expressed in both tumor and nonmalignant samples and can be used to predict the outcome of a prostate biopsy [17,18,27]. The TTTY15 gene can get fused to >zinc finger DHHC-type containing 2 (ZDHHC2– TTTY15 ), and this fusion is found in patients with acute myeloid leukemia [28]. In addition to forming fusion genes, TTTY15 (its product) can protect cardiomyocytes from hypoxia-induced cell injury by targeting miR-455-5p and thus regulating Jun dimerization protein 2 (JDP2) expression [29].…”

Section: Discussionmentioning

confidence: 99%

Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4

Lai

Chang

Chan

et al. 2019

IJMS

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Gender affects cancer susceptibility. Currently, there are only a few studies on Y chromosome-linked long noncoding RNAs (lncRNAs), and the potential association between lncRNAs and cancers in males has not been fully elucidated. Here, we examined the expression of testis-specific transcript Y-linked 15 (TTTY15) in 37 males with non-small cell lung cancer (NSCLC), and performed circular chromosome conformation capture with next-generation sequencing to determine the genomic interaction regions of the TTTY15 gene. Our results showed that the expression levels of TTTY15 were lower in NSCLC tissues. Lower TTTY15 expression levels were associated with Tumor-Node-Metastasis (TNM) stage. A TTTY15 knockdown promoted malignant transformation of NSCLC cells. Based on the bioinformatics analysis of circular chromosome conformation capture data, we found that T-box transcription factor 4 (TBX4) may be a potential target gene of TTTY15. The RNA immunoprecipitation and chromatin immunoprecipitation results showed that TTTY15 may interact with DNA (cytosine-5)-methyltransferase 3A (DNMT3A), and the TTTY15 knockdown increased the binding of DNMT3A to the TBX4 promoter. We concluded that low TTTY15 expression correlates with worse prognosis among patients with NSCLC. TTTY15 promotes TBX4 expression via DNMT3A-mediated regulation. The identification of lncRNAs encoded by male-specific genes may help to identify potential targets for NSCLC therapy.

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Section: Discussionmentioning

confidence: 99%

Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4

Lai

Chang

Chan

et al. 2019

IJMS

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“…Cancer links is defined broadly as any literature link between a ZDHHC-family member and a particular cancer, including large-scale and small-scale experimental studies, animal and cell culture studies, and clinical studies, whether functional or correlative. References: ZDHHC2[70,129,130], ZDHHC3[131][132][133], ZDHHC5[87], ZDHHC7[47,134], ZDHHC9[89,92,135,136], ZDHHC11[77,78,137,138], ZDHHC13[49,73], ZDHHC14[82][83][84][85], ZDHHC20[81], ZDHHC23[139]. HPA, Human Protein Atlas (www.proteinatlas.org/).…”

mentioning

confidence: 99%

Protein palmitoylation and cancer

2018

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Protein S-palmitoylation is a reversible post-translational modification that alters the localization, stability, and function of hundreds of proteins in the cell. S-palmitoylation is essential for the function of both oncogenes (e.g., NRAS and EGFR) and tumor suppressors (e.g., SCRIB, melanocortin 1 receptor). In mammalian cells, the thioesterification of palmitate to internal cysteine residues is catalyzed by 23 Asp-His-His-Cys (DHHC)-family palmitoyl S-acyltransferases while the removal of palmitate is catalyzed by serine hydrolases, including acyl-protein thioesterases (APTs). These enzymes modulate the function of important oncogenes and tumor suppressors and often display altered expression patterns in cancer. Targeting S-palmitoylation or the enzymes responsible for palmitoylation dynamics may therefore represent a candidate therapeutic strategy for certain cancers.

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“…A novel AML subtype (cluster C5) is characterized by enhancer deletion of ZNF37A in 16 patients ( Figure S17A). ZNF37A is involved in fusion events in breast cancer (57) and adult AML (58). Notably, AML patients with ZNF37A enhancer deletion have lower ZNF37A expression and shorter time to relapse ( Figure S17B, C), suggesting the prognosis significance of this noncoding mutation.…”

Section: Integrated Mutation Profiles Suggest Novel Disease Subtypesmentioning

confidence: 97%

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

Gao

Ding

et al. 2019

Preprint

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Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here we developed a computational framework to identify risk noncoding mutations of all classes by joint analysis of mutation and gene expression data. We identified thousands of SNVs/small indels and structural variants as candidate risk mutations in five major pediatric cancers. We experimentally validated the oncogenic role of CHD4 overexpression via enhancer hijacking in B-ALL. We observed a general exclusivity of coding and noncoding mutations affecting the same genes and pathways. We showed that integrated mutation signatures can help define novel patient subtypes with different clinical outcomes. Our study introduces a general strategy to systematically identify and characterize the full spectrum of noncoding mutations in cancers.

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First case of AML with rare chromosome translocations: a case report of twins

Cited by 9 publications

References 14 publications

Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4

Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4

Protein palmitoylation and cancer

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

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