Invasive treatment in peripheral artery disease

Deftereos, Spyridon; Vrachatis, Dimitrios; Tolis, Christos; Γιαννόπουλος, Γεώργιος

doi:10.1016/j.coph.2018.01.013

Cited by 4 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment of atherosclerosis is mainly pharmacological [ 80 ]. In patients who develop pain symptoms at rest, or when non-healing ulcerations or ceaseless chromias occur despite pharmacological or rehabilitative treatment, mechanical revascularization treatment using surgical and endovascular procedures should be implemented [ 81 , 82 ]. Endovascular surgical procedures are associated with an increased risk of complications in the form of restenosis due to endothelial and smooth muscle cell hyperplasia [ 83 ].…”

Section: Photodynamic Therapy In the Treatment Of Atherosclerosismentioning

confidence: 99%

Application of Photodynamic Therapy in Cardiology

Wańczura,

Aebisher,

Kłosowicz

et al. 2024

IJMS

View full text Add to dashboard Cite

The origins of photodynamic therapy (PDT) date back to 1904. Since then, the amount of research proving PDT and, consequently, its applicability to various disease states has steadily increased. Currently, PDT is mainly used in oncology to destroy cancer cells. It is being worked on for possible use in other medical fields as well, including cardiology. It can be used in the prevention of restenosis, often occurring after vascular surgical interventions, for destroying atherosclerotic plaques and as a new ablative method of ectopic centers in the treatment of atrial fibrillation. The purpose of this review is to summarize the knowledge to date regarding the therapeutic potential of using PDT for various pathological conditions in cardiology. The review also focuses on the current limitations associated with the use of PDT and identifies areas where more research is needed to develop better drug regimens. Materials and methods: The study analyzed 189 medical articles. The articles came from PubMed, Frontiers, Google Scholar, Science Direct and Web of Science databases. Through the excitation of light, a photosensitizer (PS) introduced into the body, the destruction of pathological cells occurs. PTD is widely used in oncology of the central nervous system (CNS). This process is made possible by the production of free oxygen radicals (ROS) and singlet oxygen, which generate oxidative stress that destroys sensitive cancer cells. In recent years, photosensitizers have also been discovered to have a strong affinity for macrophages that fill atherosclerotic plaques, making these compounds suitable for treating atherosclerosis. By inducing apoptosis of smooth muscle cells, inactivating basic fibroblast growth factor (FGF-β) and inhibiting endothelial cell hyperplasia, PDT can be used to prevent restenosis after surgical proceduresPDT appears to be a minimally invasive and highly effective therapeutic method, especially when combined with other therapeutic methods. Unfortunately, the small number of animal model studies and human clinical trials greatly limit the applicability of PDT on a wider scale. Current limitations, such as the depth of penetration, delivery of photosensitizer particles to the direct site of the lesion or the appropriate choice of photosensitizer in relation to the nature of the pathology, unfortunately make it impossible to replace current therapeutic approaches.

show abstract

Section: Photodynamic Therapy In the Treatment Of Atherosclerosismentioning

confidence: 99%

Application of Photodynamic Therapy in Cardiology

Wańczura,

Aebisher,

Kłosowicz

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…In order to identify the therapy the prognosis and indication in patients with PAD, it is crucial to distinguish between the two ideas [9], [10]. Many treatments are approved for PAD, however, they7 all have their side effects [11], [12] beyond the common pathophysiological substrate, as far as treatment is concerned, each site of atherosclerotic disease (subclavian and vertebral arteries; carotid arteries; intracranial arterial tree; renal arteries; lower extremity arteries. Therefore, the present study aims at exploring the targeting ability of phytocompound genistein against FABP4, which is associated with the development of PAD in patients having diabetes.…”

Section: Introductionmentioning

confidence: 99%

In silico Study to Investigate Targeting Ability of Genistein against Fatty acid binding protein 4 (FABP4) in Peripheral Artery Disease

Dongre¹,

Shah²,

Sharma³

2023

View full text Add to dashboard Cite

“Peripheral artery disease” or PAD, is considered as a most prevalent condition, and it commonly coexists with vascular diseases in other body parts. The epidemiology of PAD is well known and connected to age and, particularly, the predisposing factors of smoking and diabetes mellitus. Diagnosis on early basis is important for enhancing the quality of life (QOL) in addition to the reducing risk for the development of significant subsequent vascular events such as “acute myocardial infarction (AMI)” or “stroke”. There are a variety of treatments used to manage and treat the disease. However, there are negative effects and toxicities associated with that treatment in addition to higher costs. Hence, a surge in the hunt for natural compounds of botanical origin is gaining traction. The present study aims at exploring the targeting ability of phytocompound, and genistein against FABP4 which is an emerging target for PAD in diabetes patients. The study is conducted using a computation method employing Autodock4 and other accessory tools. The results of the docking process revealed a significant binding energy of -6.14 which demonstrated a stable complex formation between protein and selected compound. Thus, showing great potential for the treatment of PAD.

show abstract

Editorial overview: Cardiovascular and renal: Novel therapies in peripheral artery disease

Oikonomou

Tousoulis

2018

Current Opinion in Pharmacology

View full text Add to dashboard Cite

Invasive treatment in peripheral artery disease

Cited by 4 publications

References 51 publications

Application of Photodynamic Therapy in Cardiology

Application of Photodynamic Therapy in Cardiology

In silico Study to Investigate Targeting Ability of Genistein against Fatty acid binding protein 4 (FABP4) in Peripheral Artery Disease

Editorial overview: Cardiovascular and renal: Novel therapies in peripheral artery disease

Contact Info

Product

Resources

About