Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice

Fu, Yan; Tsauo, Jiaywei; Sun, Yu; Wang, Zhe; Kim, Kun Yung; Lee, Seung Hwan; Kim, Dong Young; Jing, Feifeng; Lim, Dahae; Song, Ho Young; Hyun, Hoon; Choi, Eun Young

doi:10.1016/j.bbrc.2018.04.158

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…Especially after a peritoneal injury caused by operation and infection, acute inflammation will be triggered first, which will lead to the activation of the coagulation system and collagen deposition. Moderate inflammation can promote wound healing, but excessive inflammation can lead to adhesion formation [40]. Macrophages are innate immune cells that play different roles in regulating inflammation, tissue repair, and other microbial infections [41].…”

Section: Discussionmentioning

confidence: 99%

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway

Zhao

Bian

Yang

et al. 2019

Mediators of Inflammation

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Intraperitoneal adhesion is a common complication after abdominal surgery, which seriously affects the quality of life of patients. HuoXueTongFu Formula (HXTF) plays an important role in the prevention and treatment of intraperitoneal adhesions. However, the molecular-related mechanisms are still not fully known. In this study, the model of Intrapetitoneal adhesion was established by cecum abrasion and treated with HXTF for one week. RAW264.7 cells were given LPS, IFN-γ, IL-4, HXTF-medicated serum, and PPAR-γ agonist/antagonist, respectively. Histopathology, flow cytometry, ELISA, real-time PCR, and Western blotting were used to further detect the related protein, M1/M2 polarization tendency, and PPAR-γ nuclear translocation. The deposition of collagen fibres reduced in the local area of rats after the operation with HXTF treatment. Similar to IL-4, HXTF induced a tendency for macrophages to polarize toward M2 and promoted peroxisome proliferator-activated receptor-gamma (PPAR-γ) nuclear translocation. Furthermore, the use of HXTF and PPAR-γ agonists downregulated macrophage M1 polarization-related factors IL-1, IL-6, and TNF-alpha and upregulated M2 polarization-related factors IL-4, IL-10, and TGF-beta 1. Meanwhile, the use of HXTF and PPAR-γ agonists downregulated the SOCS3/JAK2/STAT1 pathway and activated the SOCS1/STAT6/PPAR-γ pathway. These results show that HXTF may reduce intraperitoneal adhesion by inducing macrophage M2 polarization and regulating the SOCS/JAK2/STAT/PPAR-γ pathway.

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Section: Discussionmentioning

confidence: 99%

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway

Zhao

Bian

Yang

et al. 2019

Mediators of Inflammation

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“…DEL-1 deficiency mice exhibit increased neutrophil infiltration and inflammatory responses during lung inflammation [46]. In postoperative peritoneal adhesion (PPA) mice, EDIL3-/-mice had a higher incidence of PPA and increased inflammatory response, resulting in more severe PPA [65]. Myelopoiesis in EDIL3-/-mice was suppressed in hematopoietic stem cells (HSCs) [66].…”

Section: Structure and Functionmentioning

confidence: 99%

Developmental endothelial locus-1 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

Zhao

Zheng

et al. 2022

Preprint

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Cardiovascular and metabolic diseases (CVMDs) are a leading cause of death worldwide and imposes a huge socioeconomic burden on individuals and healthcare systems, underscoring the urgent need to develop new drug therapies. Developmental endothelial locus-1 (DEL-1) is a secreted multifunctional domain protein that can bind to integrins and play an important role in the occurrence and development of various diseases. Recently, DEL-1 has attracted great interest for its pharmacological role in the treatment and/or management of CVMDs. In this review, we present the current knowledge on the predictive and therapeutic role of DEL-1 in a variety of CVMDs, such as atherosclerosis, hypertension, cardiac remodeling, ischemic heart disease, obesity, and insulin resistance. Collectively, DEL-1 is a promising biomarker and therapeutic target for CVMDs.

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“…Del-1 deficient mice display higher neutrophil accumulation during lung inflammation, but this condition can be reversed in Del-1/LFA-1 double-deficient mice [ 14 ]. In postoperative peritoneal adhesion (PPA) mice, Del-1 deficiency increases the incidence and severity of PPA, increases acute inflammation, and increases the deposition of extracellular matrix (ECM) proteins in the surgically traumatized peritoneum [ 20 ]. In hematopoietic stem cells (HSCs), Del-1 deficiency increases long-term HSC quiescence [ 21 ].…”

Section: Structure Ligands and Functions Of Del-1mentioning

confidence: 99%

“…The role of Del-1 in this process is still unclear. Overall, Del-1 plays a role in multiple sclerosis, ankylosing spondylitis, allergic asthma, peritoneal adhesion, and other inflammatory diseases mediated by IL-17 [ 20 , 58 , 59 ]. Del-1 may be a potential therapeutic target for inflammatory diseases mediated by IL-17.…”

Section: Del-1 Is a Regulator Of Inflammationmentioning

confidence: 99%

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

Zhong

2021

Cell Mol Biol Lett

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Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer microenvironment and inflammation. Del-1 has destructive effects in most cancers and is associated with the progression and invasion of some cancers. In contrast, Del-1 also plays a protective role in inflammation. Del-1 regulates inflammation by regulating the generation of neutrophils in bone marrow, inhibiting the recruitment and migration of neutrophils and accelerating the clearance of neutrophils by macrophages. Del-1 and IL-17 are reciprocally regulated, and their balance maintains immune system homeostasis. Del-1 is expected to become a new therapeutic target for inflammatory disorders such as multiple sclerosis.

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Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice

Cited by 9 publications

References 31 publications

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway

Developmental endothelial locus-1 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

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