β-tricalcium phosphate composite ceramics with high compressive strength, enhanced osteogenesis and inhibited osteoclastic activities

Tian, Ye; Lu, Ting; He, Fupo; Xu, Yubin; Shi, Haishan; Shi, Xuetao; Zuo, Fei; Wu, Shanghua; Ye, Jiandong

doi:10.1016/j.colsurfb.2018.04.028

Cited by 32 publications

(31 citation statements)

References 45 publications

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“…It is known that that PG has significantly higher solubility compared with calcium phosphates. Previous studies demonstrated that after sintering β‐TCP with 20 wt % PG additive, the PG residues were present in the bioceramics; substantial ions of Ca and P were rapidly released from the composite bioceramics during immersion in the solution . Therefore, the TCP‐GPGs extracts showed remarkably higher Ca concentration than TCP extract, as well as notably higher P concentration compared with H‐DMEM and TCP extract.…”

Section: Discussionmentioning

confidence: 97%

“…The commercial drug strontium ranelate, which is based on strontium, is currently well accepted for treating osteoporosis in the postmenopausal women . Plentiful researches have demonstrated that incorporation of strontium into biomaterials promoted osteogenic differentiation and inhibited osteoclastic activity in vitro and in vivo …”

Section: Introductionmentioning

confidence: 99%

“…Great efforts have been made to increase the mechanical strength of β‐TCP bioceramics . Introduction of phosphate‐based glass (PG) additive is an efficient approach to improve the mechanical strength of β‐TCP bioceramics, because PG additive enables more effective liquid‐state sintering for β‐TCP . In general, the bioceramics are processed to porous form to conduct the bone growth.…”

Section: Introductionmentioning

confidence: 99%

“…13 Plentiful researches have demonstrated that incorporation of strontium into biomaterials promoted osteogenic differentiation and inhibited osteoclastic activity in vitro and in vivo. [14][15][16][17][18] Gallium (Ga) is another potent element to decrease bone resorption by inhibiting proliferation, differentiation and resorption activity of osteoclast. 19,20 Substantial clinical trials and animal experiments have demonstrated the positive effect of systemic administration of Ga ions on treating the bonerelated diseases (osteoporosis, osteopenia, Paget's disease, multiple myeloma, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…[32][33][34] Introduction of phosphate-based glass (PG) additive is an efficient approach to improve the mechanical strength of β-TCP bioceramics, because PG additive enables more effective liquidstate sintering for β-TCP. 17,18,[35][36][37] In general, the bioceramics are processed to porous form to conduct the bone growth. It is generally regarded that the minimum pore size of 100 μm supports bone ingrowth, and the size >300 μm is more beneficial for vascularization.…”

Section: Introductionmentioning

confidence: 99%

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Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption

Fang

et al. 2019

J Biomedical Materials Res

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Gallium (Ga) ions have been clinically approved for treating the diseases caused by the excessive bone resorption through the systemic administration. Nevertheless, little attention has been given to the Ga‐containing biomaterials for repairing bone defects under the pathological condition of excessive bone resorption. In the current study, for the first time the Ga‐containing phosphate glasses (GPGs) were introduced to modify the honeycomb β‐tricalcium phosphate (β‐TCP) bioceramic scaffolds, which were prepared by an extrusion method. The results indicated that the scaffolds were characterized by uniform pore structure and channel‐like macropores. The addition of GPGs promoted densification of strut of scaffolds by achieving liquid‐sintering of β‐TCP, thereby tremendously increasing the compressive strength. The ions released from scaffolds pronouncedly inhibited osteoclastogenesis‐related gene expressions and multinuclearity of RAW264.7 murine monocyte cells, as well as expressions of early osteogenic makers of mouse bone mesenchymal stem cells (mBMSCs). However, the scaffolds with lower amount of Ga increased cell proliferation and upregulated expression of late osteogenic maker of mBMSCs. This study offers a novel approach to modify the bioceramic scaffolds for bone regeneration under the condition of accelerated bone resorption. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1314–1323, 2019.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption

Fang

et al. 2019

J Biomedical Materials Res

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Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications

et al. 2023

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Regeneration of bone defects is a significant challenge today. As alternative approaches to the autologous bone, scaffold materials have remarkable features in treating bone defects; however, the various properties of current scaffold materials still fall short of expectations. Due to the osteogenic capability of alkaline earth metals, their application in scaffold materials has become an effective approach to improving their properties. Furthermore, numerous studies have shown that combining alkaline earth metals leads to better osteogenic properties than applying them alone. In this review, the physicochemical and physiological characteristics of alkaline earth metals are introduced, mainly focusing on their mechanisms and applications in osteogenesis, especially magnesium (Mg), calcium (Ca), strontium (Sr), and barium (Ba). Furthermore, this review highlights the possible cross‐talk between pathways when alkaline earth metals are combined. Finally, some of the current drawbacks of scaffold materials are enumerated, such as the high corrosion rate of Mg scaffolds and defects in the mechanical properties of Ca scaffolds. Moreover, a brief perspective is also provided regarding future directions in this field. It is worth exploring that whether the levels of alkaline earth metals in newly regenerated bone differs from those in normal bone. The ideal ratio of each element in the bone tissue engineering scaffolds or the optimal concentration of each elemental ion in the created osteogenic environment still needs further exploration. The review not only summarizes the research developments in osteogenesis but also offers a direction for developing new scaffold materials.

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Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells

Liu,

Luo,

Liao

et al. 2024

J Biomed Mater Res

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Strontium (Sr) has important functions in bone remodeling. Incorporating strontium‐doped α‐calcium sulfate hemihydrate (SrCSH) into poly(lactic‐co‐glycolic acid) (PLGA) fibrous scaffolds were expected to increase its bio‐activity and provide a potential material for bone tissue engineering. In the present study, Sr‐containing aligned PLGA/SrCSH fibrous scaffolds similar to the architecture of natural bone were prepared via wet spinning. CCK‐8 assay revealed that Sr‐containing scaffolds possessed better bioactivity and supported favorable cell growth effectively. The aligned PLGA/SrCSH fibers exerted a contact effect on cell attachment, inducing regular cell alignment and influencing a series of cell behaviors. Releasing of high concentration Sr from a‐PLGA/SrCSH scaffolds could induce high expression levels of BMP‐2, increase ALP activity and upregulate RUNX‐2 expression, and further promote the expressions of COL‐I and OCN and the maximum mineralization. This study demonstrated that Sr and ordered structure in a‐PLGA/SrCSH fibrous scaffolds could synergistically enhance the osteogenic differentiation of umbilical cord mesenchymal stem cells (UCMSCs) by regulating cell arrangement and expressions of osteogenic genes.

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β-tricalcium phosphate composite ceramics with high compressive strength, enhanced osteogenesis and inhibited osteoclastic activities

Cited by 32 publications

References 45 publications

Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption

Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption

Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications

Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells

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