Liposomal formulations of magnesium sulfanyl tribenzoporphyrazines for the photodynamic therapy of cancer

Piskorz, Jaroslaw; Mlynarczyk, Dariusz T.; Szczołko, Wojciech; Konopka, Krystyna; Düzgüneş, Nejat; Mielcarek, Jadwiga

doi:10.1016/j.jinorgbio.2018.04.010

Cited by 23 publications

(11 citation statements)

References 38 publications

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“…The positive charge, important to sufficient bacteria photoinactivation, was provided by a liposome ingredient—chloride salt of DOTAP. The size of the liposomes corresponded to earlier prepared formulations [ 55 ]. The average diameter of the obtained liposomes was measured at 301 nm, 188 nm, and 119 nm for 1, 2, and MgPc, respectively ( Table 2 ).…”

Section: Resultsmentioning

confidence: 81%

“…The photocytotoxicity of tribenzoporphyrazines 1 and 2 against cancer cells was evaluated before. It was reported that among the studied liposomal formulations loaded with 1 and 2, POPC:DOTAP liposomes presented the lowest IC 50 values against oral carcinoma cell lines (CAL-27, HSC-3) [ 45 , 55 ]. A simple topical administration route and an easy light delivery create perspectives for the effective treatment of bacterial infections associated with oral cancers in one medical procedure.…”

Section: Resultsmentioning

confidence: 99%

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Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Stolarska

Glowacka-Sobotta

Mlynarczyk

et al. 2020

IJMS

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Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties were very weak, with fluorescence quantum yields in the range of only 0.002–0.051. What is important, they revealed moderate abilities to form singlet oxygen with the quantum yields up to 0.27. Under irradiation, the macrocycles decomposed via photobleaching mechanism with the quantum yields up to 8.64 × 10−5. The photokilling potential of tribenzoporphyrazines was assessed against Streptococcus pyogenes, Staphylococcus epidermidis, as well as various strains of Staphylococcus aureus, including methicillin-sensitive and-resistant bacteria. Both evaluated photosensitizers revealed high photodynamic potential against studied bacteria (>3 logs). S.aureus growth was reduced by over 5.9 log, methicillin-resistant S. aureus by 5.1 log, S.epidermidis by over 5.7 log, and S. pyogenes by over 4.7 log.

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Stolarska

Glowacka-Sobotta

Mlynarczyk

et al. 2020

IJMS

Self Cite

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“…Since miRNAs are negatively charged, we need a positively charged material to carry miR-139-5p through electrostatic adsorption. DOTAP is a commonly used cationic liposome that is biologically inert, biodegradable, and nonimmunogenic. , It forms a stable transfection complex with the nucleic acid into the cell and releases the nucleic acid into the cell without harm. Therefore, we chose DOTAP as an adjuvant for cationic liposomes.…”

Section: Discussionmentioning

confidence: 99%

EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer

Zhao

et al. 2019

Mol. Pharmaceutics

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Colorectal cancer (CRC) is one of the most common cancers worldwide. MicroRNAs (miRNAs) play a vital role in a variety of biology processes. Our previous work identified miR-139-5p as a tumor suppressor gene overexpressed in CRC that assisted in inhibiting progression of cancer. The main challenge of miRNAs as therapeutic agents is their rapid degradation in plasma, poor uptake, and off-target effects. Therefore, the development of miRNA-based therapies is necessary. In this study, we developed a cationic liposome-based nanoparticle loaded with miR-139-5p (miR-139-5p-HSPC/DOTAP/Chol/DSPE-PEG2000-COOH nanoparticles, MNPs) and surface-decorated with epithelial cell adhesion molecule (EpCAM) aptamer (Apt) (miR-139-5p-EpCAM Apt-HSPC/DOTAP/Chol/DSPE-PEG2000-COOH nanoparticles, MANPs) for the targeted treatment of CRC. The size of MANPs was 150.3 ± 8.8 nm, which had a round-shaped appearance and functional dispersion capabilities. It also showed negligible hemolysis in the blood. MANPs markedly inhibited the proliferation, migration, and invasion of one or more CRC cell lines in vitro. Furthermore, we demonstrated the uptake and targeting ability of MANPs in vivo and in vitro. MANPs inhibit the growth of HCT8 cells in vitro and have a significant tumor suppressive effect on subcutaneous HCT8 colorectal tumor mice. Our results demonstrated that MANPs were an effective carrier approach to deliver therapeutic miRNAs to CRC.

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“…[68] Liposomal dendritic magnesium sulfanyl tribenzoporphyrazine Pz 1-3 as PSs [69] activated by NIR irradiation demonstrated significantly better phototoxicity in cancer cell lines (Figure 3). [70] Diazepinoporphyrazines modified with peripheral styryl groups were encapsulated in liposomes for PDT against oral cancer cell lines. [71] The photocytoxicity of Pz1 was increased by nearly 3-fold (from IC 50 45 nm to IC 50 129 nm) compared with that of the solution of Pz1.…”

Section: Icg-c18mentioning

confidence: 99%

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

et al. 2021

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Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi‐functional nano‐carriers for drug delivery, have been extensively studied in multi‐functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image‐guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome‐based drug delivery.

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Liposomal formulations of magnesium sulfanyl tribenzoporphyrazines for the photodynamic therapy of cancer

Cited by 23 publications

References 38 publications

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

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