Serum retinol binding protein 4 and galectin-3 binding protein as novel markers for postmenopausal nonalcoholic fatty liver disease

Cai, Hong; Lu, Sha; Chen, Yueming; Mrcog, Sayantana Das Mbbs; Niu, Zhenbin; Zhuo, Guangchao; Lai, Lei; Zhang, Zhifen

doi:10.1016/j.clinbiochem.2018.04.017

Cited by 20 publications

(22 citation statements)

References 23 publications

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“…21 33 Third, inflammation is also a mechanism to account for such associations. Galectin-3BP is implicated in inflammatory distress, immune response 15 and chronic low-grade inflammation. 21 It is widely reported that inflammation is essential to the pathogenesis underlying MetS.…”

Section: Discussionmentioning

confidence: 99%

“…12 13 The full complement of galectin-3BP biological activities is not known, but it is known that galectin-3BP participates in cell growth, inflammation, cellular adhesion, and an increase in visceral fat deposition. [13][14][15] Additionally, it has been reported that galectin-3BP expression is detected among different cell types, such as mucosal or glandular epithelium and hematopoietic cells 16 17 ; galectin-3BP is highly expressed within serum in patients with hepatitis, non-alcoholic fatty liver disease, and autoimmune disease. 15 17 Plasma galectin-3BP has been reported to be elevated in obese individuals 18 19 and individuals with symptoms of MetS.…”

Section: Significance Of This Studymentioning

confidence: 99%

“… 13–15 Additionally, it has been reported that galectin-3BP expression is detected among different cell types, such as mucosal or glandular epithelium and hematopoietic cells 16 17 ; galectin-3BP is highly expressed within serum in patients with hepatitis, non-alcoholic fatty liver disease, and autoimmune disease. 15 17 Plasma galectin-3BP has been reported to be elevated in obese individuals 18 19 and individuals with symptoms of MetS. 19–21 To the best of our knowledge, however, most previous studies involved adults; the variations in galectin-3BP expression among obese adolescents or adolescents with MetS have rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

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Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

Zhen

Han

et al. 2021

BMJ Open Diab Res Care

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IntroductionChildhood obesity (OB) and metabolic syndrome (MetS) have become a worldwide health problem. Comparative proteomic approaches are widely used in human OB to analyze protein changes in blood plasma. The present study determined the galectin-3 binding protein (galectin-3BP) expression level in different weight categories and assessed the associations between galectin-3BP and OB and MetS.Research design and methodsThe current study included 932 Chinese adolescents 13–18 years of age. The biochemical and anthropometric variables of all the subjects were evaluated using standardized procedures. The differentially expressed proteins (DEPs) were investigated among 60 adolescents (20 normal weight, 20 overweight and 20 obese) using tandem mass tag (TMT) quantitative proteomics. The serum galectin-3BP level was measured using ELISA. The associations between galectin-3BP and OB and MetS were analyzed in 932 adolescents using multiple logistic regression analyses.ResultsA significant DEP, galectin-3BP, can effectively separate the obese from the normal weight group using TMT. Adolescents in tertile 3 of galectin-3BP, when compared with adolescents in the tertile 1, were positively associated with OB (OR=3.32, 95% CI 1.79 to 6.16) and MetS (OR=3.28, 95% CI 1.30 to 8.26). The receiver operating characteristic curve for galectin-3BP in subjects with MetS indicated that the area under the curve was 0.85 (95% CI 0.79 to 0.91).ConclusionsThis study confirmed an association between galectin-3BP and OB in Chinese adolescents, and galectin-3BP was also positively associated with MetS, and thus might be useful for identifying adolescents with MetS.

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Section: Discussionmentioning

confidence: 99%

Section: Significance Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

Zhen

Han

et al. 2021

BMJ Open Diab Res Care

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“…2). The most prevalent biological processes were single-organism process (18), cellular process (16), single-organism cellular process (15), and biological regulation (13). The most prevalent cellular components were located in the cell part (22), cell (22) and intracellular (22).…”

Section: Go Functional Annotation Analysismentioning

confidence: 99%

Proteomics for studying the effects ofL. rhamnosusLV108 against non-alcoholic fatty liver disease in rats

Yu²,

et al. 2018

RSC Adv.

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“…G3BP is involved in inflammatory distress and immune response. Retinol-binding protein (RBP4) is known as a unique biomarker for insulin resistance and obesity 9,11,10 . Newly identified RBP4 refers to the lipocalin family and is the exact transporter protein for vitamin A in the blood.Itis prominently expressed on the hepatic cell and adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

Hassan,

Dawood,

Hussein

2021

MLU

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nonalcoholic fatty liver disease starts with liver fat accumulation which is a dangerous factor for disease progression. So, we aimed to determine some biochemical parameters among patients with NAFLD and healthy individuals. Sixty patients with NAFLD and thirtyhealthy control who were attending Gastroenterology and Hepatology Teaching Hospital/Baghdad during the period from August /2019 to March /2020. Which included age, sex, BMI, and abdominal ultrasound result with other medical information. Then all the biochemical test is done by Autoanalyzer, while serum galectin 3 binding protein andserum retinol 4 binding protein measured using ELISAtechnique.Our study found that obesity (70%) and dyslipidemia (50%) were more common in patients with NAFLD than other metabolic diseases. NAFLD subjects showa highly significant elevated (p=0.000) in the mean ± SD of BMI, FBS, HbA1, ALP, triglyceride, VLDL, GGT, and G3BP comparedto the healthy controls. Also,serum ALT, total bilirubin, cholesterol, and RBP4 were highly significantly elevated (p=0.001) in the mean ± SD of NAFLD when compared tomean± SD of healthy control.However, it revealed a significant raise (P=0.027) in the mean ± SD of the serum albumin in the NAFLD patients when compared to the mean ± SD of the healthy control and a significant elevated (P=0.002)in the mean ± SD of the LDL in the NAFLD patients and healthy control. But showed a significant decrease (P=0.029) in the mean ± SD of the serum HDL of the NAFLD patient when compared tothe mean ± SD of the healthy control.Finally, we found that the optimal cut-off value for GGT was >25 IU/l with sensitivity and specificity (93.33% and 70%) respectively and RBP4 has an optimal cut-off value >22.28 ng/ ml with sensitivity and specificity (83.33% and 56.67 %) respectively. Therefore, the optimal cut-off value was > 9.49 ng/ml for G3BP with sensitivity and specificity (93.33 % and 83.33% ) respectively.

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Serum retinol binding protein 4 and galectin-3 binding protein as novel markers for postmenopausal nonalcoholic fatty liver disease

Cited by 20 publications

References 23 publications

Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

Proteomics for studying the effects ofL. rhamnosusLV108 against non-alcoholic fatty liver disease in rats

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

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