Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?

Uysal, Nazan; Kızıldağ, Servet; Yüce, Zeynep; Güvendi, Güven; Kandiş, Sevim; Koç, Başar; Karakiliç, Aslı; Camsari, Ulas M.; Ateş, Mehmet

doi:10.1007/s12011-018-1351-9

Cited by 22 publications

(8 citation statements)

References 26 publications

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“…This review explored also publications on the bioavailability of the different Mg salts in order to identify specificities among pharmaceutical preparations. A number of publications have studied 17 Mg salts in preclinical and clinical conditions [ 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. Comparison of the oral bioavailability and absorption of different pharmaceutical forms of inorganic and organic Mg salts has been explored in 5 RCTs [ 113 , 114 , 115 , 116 , 117 ] ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Magnesium for Pain Treatment in 2021? State of the Art

et al. 2021

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Background: Magnesium (Mg) is commonly used in clinical practice for acute and chronic pain and has been reported to reduce pain intensity and analgesics consumption in a number of studies. Results are, however, contested. Objectives: This review aims to investigate randomised clinical trials (RCTs) on the effectiveness of Mg treatment on pain and analgesics consumption in situations including post-operative pain, migraine, renal pain, chronic pain, neuropathic pain and fibromyalgia. Results: The literature search identified 81 RCTs (n = 5447 patients) on Mg treatment in pain (50 RCTs in post-operative pain, 18 RCTs in migraine, 5 RCTs in renal pain, 6 RCTs in chronic/neuropathic pain, 2 RCTs in fibromyalgia). Conclusion: The level of evidence for the efficacy of Mg in reducing pain and analgesics consumption is globally modest and studies are not very numerous in chronic pain. A number of gaps have been identified in the literature that need to be addressed especially in methodology, rheumatic disease, and cancer. Additional clinical trials are needed to achieve a sufficient level of evidence and to better optimize the use of Mg for pain and pain comorbidities in order to improve the quality of life of patients who are in pain.

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Section: Resultsmentioning

confidence: 99%

Magnesium for Pain Treatment in 2021? State of the Art

et al. 2021

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“…Currently, several generations of magnesium-containing preparations depending on their pharmacological properties are distinguished (Trisvetova 2012). It was proved that the first-generation drugs, represented by inorganic magnesium compounds, have little effect on the balance of this element in the body (Ates et al 2019;Uysal et al 2019). Magnesium oxide, dioxide, carbonate and phosphate exhibit primarily antacid properties, but are not used in correcting magnesium deficiency.…”

Section: Resultsmentioning

confidence: 99%

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Sankova

Kytko

Meylanova

et al. 2020

RRP

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Introduction: The relevance of the issue of increasing stress resistance is due to a significant deterioration in the mental health of the population caused by the special conditions of the disease control and prevention during the COVID-19 pandemic. Recently, the decisive role in the severity of clinico-physiological manifestations of maladjustment to stress is assigned to magnesium ions. The aim of the work was to study the magnesium importance in the body coping mechanisms under stress for the pathogenetic substantiation of the magnesium correction in an unfavorable situation of disease control and prevention during the COVID-19 pandemic. Materials and methods: The theoretical basis of this scientific and analytical review was an analysis of modern Russian and foreign literature data posted on the electronic portals MEDLINE, PubMed-NCBI, Scientific Electronic Library eLIBRARY.RU, Google Academy, and CyberLeninka. Results and discussion: It was shown that the total magnesium level in the body plays the indicator role of the body functional reserves. Acute and chronic stresses significantly increase the magnesium consumption and cause a decrease in its body content. Magnesium deficiency is one of the main pathogenetic mechanisms of reducing stress resistance and adaptive body reserves. Arising during the COVID-19 pandemic, increased nervous and emotional tension, the lack of emotional comfort and balance can lead to the onset or deterioration of magnesium deficiency, which manifests itself in mental burnout and depletion of adaptive capacities. The inability to synthesize magnesium in the body necessitates including foodstuffs high in magnesium in the population diet during this period. The appointment of magnesium preparations is pathogenetically justified with moderate and severe magnesium deficiency. This therapy should take into account the major concomitant diseases, severity of magnesium deficiency, and a patient’s age. Conclusion: magnesium correction, carried out during the COVID-19 pandemic, will contribute to increasing stress resistance, preventing mental diseases and improving the population’s life quality.

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“…Since the early 1900s, Americans are now consuming half of the Mg of what they used to, dropping from about 500mg/day to 250mg/day(49). This may be due in part to the typical, overly processed American western diet which has decreased Mg content of food by about 85%(49,58). Americans have increased processed food consumption, which can therefore affect American's dietary Mg intake(49).…”

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confidence: 99%

“…Magnesium toxicity is rare, and has only occurred through consuming supplements with no reports of toxicity exclusively through dietary intake(11).The use of Mg dietary supplements can increase Mg intake. Magnesium supplements are typically in the form of Mg oxide, citrate, stearate, acetyl taurate, or chloride(43,58). Magnesium citrate and Mg oxide are most frequently prescribed when dietary supplementation is necessary(58).…”

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confidence: 99%

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Dietary and Supplemental Magnesium Intake During Pregnancy and Its Association With Gestational Diabetes

Palmer¹

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Background: Gestational diabetes mellitus (GDM) is a prevalent and growing epidemic that affected 8.2% of births in 2016 in the United States. Previous studies have shown that low magnesium (Mg) is associated with type II diabetes (T2DM), and the pathophysiology of GDM and T2DM is similar. Objective: To determine if low total Mg intake is associated with the risk of having GDM. Design: We did a cross-sectional secondary data analysis using data from the 2005-2007 Infant Feeding Practices Study II which used a validated diet history questionnaire to collect dietary data. We analyzed total Mg intake from 1217 pregnant women in their third trimester and ran unadjusted and adjusted logistic regression models. Adjusted models included age, pre-pregnancy BMI, family history of T2DM, energy intake from food, and smoking as covariates. Results: Mean total Mg intake was 332+138mg/day and 8.8% of women consumed a dietary supplement containing Mg. In the unadjusted model, risk of GDM was not higher with low total Mg intake (OR [95% CI]: 0.96 [0.61, 1.51]). Adjusting for all covariates did not change the association (1.06 [0.64, 1.76]). Conclusions: Total Mg intake was not significantly associated with a higher risk of developing GDM. While this study found no association, a study with a larger sample size and adequate power, using dietary intake to measure total Mg status may indicate more significant findings.

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Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?

Cited by 22 publications

References 26 publications

Magnesium for Pain Treatment in 2021? State of the Art

Magnesium for Pain Treatment in 2021? State of the Art

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Dietary and Supplemental Magnesium Intake During Pregnancy and Its Association With Gestational Diabetes

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