Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20‐year longitudinal study

Lieshout, Ryan J. Van; Ferro, Mark A.; Boyle, Michael H.; Saigal, Saroj; Morrison, Katherine M.; Mathewson, Karen J.

doi:10.1111/jcpp.12909

Cited by 37 publications

(26 citation statements)

References 59 publications

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“…Generally, the greater persistence of problems over time in this study compared with other very and extremely low birth weight cohorts [2,14,16,30,39] may also be related to the greater neurodevelopmental immaturity at birth, higher risk for neonatal brain injury and reduced neurodevelopmental plasticity that is conferred by birth at extremely low gestations compared with birth after 26 weeks of gestation. Indeed, moderate/severe cognitive impairment, an index of such factors [40,41], accounted for some of the difference in the overall behavioral problems with those having cognitive difficulties having persistently greater problems, but did not explain the excess entirely.…”

Section: Discussionmentioning

confidence: 71%

“…The few longitudinal studies that have investigated the prevalence of behavioral symptoms or disorders in children and adolescents who were born preterm or low birth weight have shown that the increased prevalence of problems persists over time and may have greater stability in individuals born preterm compared with those born at term or with normal birthweight [2,[12][13][14][15][16]. Many of these previous studies employed cross-sectional analysis techniques which are not able to detect variation in individual trajectories; or they focussed on specific disorders such as ADHD.…”

Section: Introductionmentioning

confidence: 99%

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Trajectories of behavior, attention, social and emotional problems from childhood to early adulthood following extremely preterm birth: a prospective cohort study

Linsell

Johnson

Wolke

et al. 2018

Eur Child Adolesc Psychiatry

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To investigate trajectories of behavior, attention, social and emotional problems to early adulthood in extremely preterm survivors compared to a term-born comparison group. Longitudinal analysis of a prospective, population-based cohort of 315 surviving infants born < 26 completed weeks of gestation recruited at birth in 1995, from the UK/Republic of Ireland, and a term-born comparison group recruited at age 6. The parent-report Strengths and Difficulties Questionnaire was completed at age 6, 11, 16 and 19 years. The Total Behavioral Difficulties Score was 4.81 points higher in extremely preterm individuals compared to their term-born peers over the period (95% CI 3.76-5.87, p < 0.001) and trajectories were stable in both groups. The impact of difficulties on home life, friendships, school or work and/or leisure activities was greater in the EPT group (RR 4.28, 95% CI 2.89-6.35, p < 0.001), and hyperactivity/inattention and peer problems accounted for the largest differences. A clinically significant behavioral screen at age 2.5 was associated with a higher Total Behavioral Difficulties Score from 6 years onwards in extremely preterm participants (Mean difference 6.90, 95% CI 5.01-8.70, p < 0.0.01), as was moderate/ severe cognitive impairment at last assessment (Mean difference: 4.27, 95% CI 2.76-5.77, p < 0.001). Attention, social and emotional problems in extremely preterm individuals persist into early adulthood with significant impact on daily life. A positive behavioral screen in infancy and moderate/severe cognitive impairment are associated with early adult outcomes.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Trajectories of behavior, attention, social and emotional problems from childhood to early adulthood following extremely preterm birth: a prospective cohort study

Linsell

Johnson

Wolke

et al. 2018

Eur Child Adolesc Psychiatry

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“…Existing research has identified sensitive parenting in childhood [ 5 ] as a potential resilience factor for academic achievement among very preterm children (i.e., in very preterm children sensitive parenting was more strongly associated with academic outcomes than in term born children). By contrast, a recent study reported that very preterm children may be more strongly affected by risk factors for mental health such as family dysfunction, parental mental health problems, and peer victimisation while not benefitting as much from potential resilience factors such as number of close friends or sensitive parental care compared to term born children [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Mental Health, and Well-Being in Very Pre-Term and Term Born Adolescents: An Individual Participant Data Meta-Analysis of Two Accelerometry Studies

Brylka

Wolke

Ludyga

et al. 2021

IJERPH

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This study examined whether physical activity is associated with better mental health and well-being among very preterm (≤32 weeks) and term born (≥37 weeks) adolescents alike or whether the associations are stronger in either of the groups. Physical activity was measured with accelerometry in children born very preterm and at term in two cohorts, the Basel Study of Preterm Children (BSPC; 40 adolescents born ≤32 weeks of gestation and 59 term born controls aged 12.3 years) and the Millennium Cohort Study (MCS; 45 adolescents born ≤32 weeks of gestation and 3137 term born controls aged 14.2 years on average). In both cohorts, emotional and behavioral problems were mother-reported using the Strengths and Difficulties Questionnaire. Subjective well-being was self-reported using the Kidscreen-52 Questionnaire in the BSPC and single items in the MCS. Hierarchical regressions with ‘preterm status × physical activity’-interaction effects were subjected to individual participant data (IPD) meta-analysis. IPD meta-analysis showed that higher levels of physical activity were associated with lower levels of peer problems, and higher levels of psychological well-being, better self-perception/body image, and school related well-being. Overall, the effect-sizes were small and the associations did not differ significantly between very preterm and term born adolescents. Future research may examine the mechanisms behind effects of physical activity on mental health and wellbeing in adolescence as well as which type of physical activity might be most beneficial for term and preterm born children.

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“…Preterm birth is closely associated with increased risk of neurodevelopmental, cognitive and psychiatric impairment that extends across the life course (Nosarti et al, 2012; Anderson, 2014; Mathewson et al, 2017; Van Lieshout et al, 2018). Structural and diffusion MRI (sMRI and dMRI) support the conceptualisation of atypical brain growth after preterm birth as a process characterised by micro-structural alteration of connective pathways due to impaired myelination and neuronal dysmaturation (Boardman et al, 2006; Anjari et al, 2007; Counsell et al, 2008; Ball et al, 2013; Back and Miller, 2014; Van Den Heuvel et al, 2015; Eaton-Rosen et al, 2015; Thompson et al, 2016; Batalle et al, 2017; Telford et al, 2017; Batalle et al, 2018); and the ensuing ‘dysconnectivity phenotype’ could form the basis for long term functional impairment (Boardman et al, 2010; Caldinelli et al, 2017; Keunen et al, 2017; Cao et al, 2017; Batalle et al, 2018b).…”

Section: Introductionmentioning

confidence: 99%

Neonatal morphometric similarity mapping for predicting brain age and characterizing neuroanatomic variation associated with preterm birth

Galdi

Blesa

Stoye

et al. 2019

Preprint

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1Multi-contrast MRI captures information about brain macro-and micro-structure which can be combined in an inte-2 grated model to obtain a detailed "fingerprint" of the anatomical properties of an individual's brain. Inter-regional 3 similarities between features derived from structural and diffusion MRI, including regional volumes, diffusion tensor 4 metrics, neurite orientation dispersion and density imaging measures, can be modelled as morphometric similarity net-5 works (MSNs). Here, individual MSNs were derived from 105 neonates (59 preterm and 46 term) who were scanned 6 between 38 and 45 weeks postmenstrual age (PMA). Inter-regional similarities were used as predictors in a regression 7 model of age at the time of scanning and in a classification model to discriminate between preterm and term infant 8 brains. When tested on unseen data, the regression model predicted PMA at scan with a mean absolute error of 0.70 ± 9 0.56 weeks, and the classification model achieved 92% accuracy. We conclude that MSNs predict chronological brain 10 age accurately; and they provide a data-driven approach to identify networks that characterize typical maturation and 11 those that contribute most to neuroanatomic variation associated with preterm birth. 12 Significance Statement 13 Preterm birth affects 15 million deliveries each year and is closely associated with intellectual disability, educational 14under-performance and psychiatric disorders. Imaging studies reveal a cerebral signature of preterm birth that includes 15 alterations in brain structure and network connectivity, but there has not been a unified data-driven approach that 16 incorporates all available information from MRI. We report that morphometric similarity networks (MSNs), which 17 integrate information from structural MRI and diffusion MRI in a single model, accurately predict brain age. MSNs 18 reveal the networks that characterize maturation and those that contribute to neuroanatomic variation associated with 19 preterm birth. MSNs are extensible and offer a new approach for investigating early life origins of neurodevelopmental 20 and mental health disorders 21 1

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Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20‐year longitudinal study

Cited by 37 publications

References 59 publications

Trajectories of behavior, attention, social and emotional problems from childhood to early adulthood following extremely preterm birth: a prospective cohort study

Trajectories of behavior, attention, social and emotional problems from childhood to early adulthood following extremely preterm birth: a prospective cohort study

Physical Activity, Mental Health, and Well-Being in Very Pre-Term and Term Born Adolescents: An Individual Participant Data Meta-Analysis of Two Accelerometry Studies

Neonatal morphometric similarity mapping for predicting brain age and characterizing neuroanatomic variation associated with preterm birth

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