3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity

Husain, Nazim; Mahmood, Riaz

doi:10.1016/j.tiv.2018.04.004

Cited by 23 publications

(11 citation statements)

References 98 publications

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“…Additionally, 3,4-DHB possesses anti-inflammatory activities, neuroprotective effects against oxidative stress, and anticancer activities [23]. 3,4-DHB is a structurally simple polyphenolic compound found in grapevine leaves, buckwheat, barley, green cavendish bananas, and Chinese red sage plants [24][25][26]. It is widely used as a food flavor and pharmaceutical intermediate.…”

Section: 4-dihydroxybenzaldehyde (34-dhb)mentioning

confidence: 99%

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Kuo

Pei

Chao

2022

Plants

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Orchidaceae is one of the largest families of flowering plants with more than 27,000 accepted species, and more than 31,000–35,000 species are estimated to exist in total. The orchid Spiranthes sinensis (Pers.) Ames, having ornamental and medicinal value, is widely distributed throughout Asia and Oceania. S. sinensis (Shou Tsao) is also known as Panlongshen among the common folk herbs. It has a fleshy root similar to ginseng, and the entire plant is widely used in traditional Chinese medicine. Owing to overexploitation and habitat destruction in recent years, the wild population has become scarce. The traits of this species show obvious differences in different countries. In the Taiwanese climate, it flowers during the Ching Ming Festival, also called the ching ming tsao. Previous investigations into S. sinensis have revealed the presence of flavonoids, homocyclotirucallane, dihydrophenanthrenes, ferulic acid, and 3,4-dihydroxybenzaldehyde. Phenolic constituents of structural and biological interest, including phenanthrenes and flavonoids, have been isolated and identified from S. sinensis. This natural product possesses extensive bioactivity, including anti-tumor, anti-inflammatory, and antioxidant effects. In this review, we outline the herbal medicine formulations and plant-derived natural products of S. sinensis.

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Section: 4-dihydroxybenzaldehyde (34-dhb)mentioning

confidence: 99%

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Kuo

Pei

Chao

2022

Plants

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“…To ensure accurate identification, it is important to check the conformity of various factors using standard materials. Compound 2,3-dihydroxybenzaldehyde exhibited strong antioxidant activity, protecting against hypotensive effects, genotoxicity, and cytotoxicity [29,30]. In order to receive attention as a valuable food along with the leaves of Amaranthus, it is necessary to try more elaborate confirmation by comparing retention time, mass ions, and fragmentation ions after securing the real standard of the substance.…”

Section: Chemical Profiling Of Phenolic Compounds In Seed Samplesmentioning

confidence: 99%

Establishment of a UPLC-PDA/ESI-Q-TOF/MS-Based Approach for the Simultaneous Analysis of Multiple Phenolic Compounds in Amaranth (A. cruentus and A. tricolor)

et al. 2020

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We used ultraperformance liquid chromatography coupled with a photodiode-array detector and electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-PDA/ESI-Q-TOF/MS) to rapidly and accurately quantify 17 phenolic compounds. Then, we applied this method to the seed and leaf extracts of two Amaranthus species to identify and quantify phenolic compounds other than the 17 compounds mentioned above. Compounds were eluted within 30 min on a C18 column using a mobile phase (water and acetonitrile) containing 0.1% formic acid, and the specific wavelength and ion information of the compounds obtained by PDA and ESI-Q-TOF/MS were confirmed. The proposed method showed good linearity (r2 > 0.990). Limits of detection and quantification were less than 0.1 and 0.1 μg/mL, respectively. Intra- and interday precision were less than 2.4% and 1.8%, respectively. Analysis of amaranth seed and leaf extracts using the established method showed that the seeds contained high amounts of 2,4-dihydroxybenzoic acid and kaempferol, and leaves contained diverse phenolic compounds. In addition, six tentatively new phenolic compounds were identified. Moreover, seeds potentially contained 2,3-dihydroxybenzaldehyde, a beneficial bioactive compound. Thus, our method was an efficient approach for the qualitative and quantitative analysis of phenolic compounds, and could be used to investigate phenolic compounds in plants.

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“…It is found on surface coatings and in water systems under alkaline pH and mild oxidizing conditions posing a major environmental health challenge (5). It easily permeates the cell membrane with the aid of the sulphate anion transport system present in the membrane and thereafter reduced to other lower oxidation states, leading to accumulation in various organs and triggering a multiplex of reactive oxygen species (ROS) and organ damage (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

Ejoh

Iheagwam

Olusola

2021

Jundishapur J Nat Pharm Prod

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Background: Chromium and its salts, as well as chromium-containing compounds, play a major role in numerous manufacturing processes and have been contraindicated in carcinogenic, toxic, and mutagenic conditions in people involved in these processes. Objectives: This study investigated the ameliorative role of Acacia nilotica aqueous leave extract (ANLA) on potassium dichromate-induced liver and blood toxicity in male and female rats. Phytochemical screening and nutrient composition of ANLA were also evaluated. Methods: Phytochemical and proximate analysis of ANLA were carried out. Twenty adult male and female rats each were divided into four groups (n = 10): (1) control; (2) potassium dichromate (PDC; 0.625 mg/kg body weight); (3) PDC co-treated with ANLA after seven days (650 mg/kg bwt); and (4) PDC co-treated with ANLA (650 mg/kg bwt) simultaneously for 21 days. Biomarkers of liver injury, lipid, and hematological imbalance were assessed. Tissue histology and toxicant retention were done. Results: Various plant secondary metabolites (flavonoids, terpenoids, tannins, phenols, saponins, cardiac glycosides, alkaloids, and anthraquinones) and nutrients (protein = 67.41 ± 2.44%; carbohydrate = 9.87 ± 1.87%; fiber = 10.01 ± 1.21%; mineral = 6.41 ± 1.08%; fat and oil = 6.63 ± 0.93%) were identified in the leave. Exposure to chromium significantly (P < 0.05) increased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with a concomitant decrease in the activity of these enzymes in the liver of both male and female rats. The exposure also altered protein, triglyceride, and cholesterol levels in the plasma and liver as well as hematological indices. Organ chromium retention and pathological changes were also observed. ANLA modulated these chromium-induced alterations in the rats. Conclusions: Based on the results, ANLA indicates ameliorative property against PDC-induced toxicity in rats. Thus it may be used to combat chromium poisoning. The nutritive potential of A. nilotica leaves may also be maximized.

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3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity

Cited by 23 publications

References 98 publications

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Establishment of a UPLC-PDA/ESI-Q-TOF/MS-Based Approach for the Simultaneous Analysis of Multiple Phenolic Compounds in Amaranth (A. cruentus and A. tricolor)

Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

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