Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis

Stylianou, Myrto; Murphy, Nicholas; Peraza, Luis R.; Graziadio, Sara; Cromarty, Ruth; Killen, Alison; Brien, John T. O’; Thomas, Alan; LeBeau, Fiona E. N.; Taylor, John‐Paul

doi:10.1016/j.clinph.2018.03.013

Cited by 48 publications

(75 citation statements)

References 61 publications

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“…We decided to use individual alpha peak frequencies to determine alpha power instead of using a fixed alpha frequency band (usually from 8 to 12 Hz) [21,22]. This was done to account for a shift of the alpha peak to slower frequencies in AD and LBD [26,27]. The mean alpha peak in the LBD group therefore lies within a frequency range that has been termed pre-alpha [41,42], but is also considered to represent the fast-theta band in other studies [27].…”

Section: Discussionmentioning

confidence: 99%

“…Individual alpha peak frequencies were calculated by finding the peak in the PSD in the extended alpha frequency band from 4 to 14 Hz [20] using the eyes-closed data. Individual alpha peak frequencies were used instead of the standard alpha frequency band to account for a shift of the alpha peak to slower frequencies in AD and LBD [26,27].…”

Section: Alpha Reactivity Analysismentioning

confidence: 99%

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EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

et al. 2020

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Background: Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in Alzheimer's disease (AD) and are mainly caused by degeneration of the nucleus basalis of Meynert (NBM) whose widespread cholinergic projections provide the main source of cortical cholinergic innervation. EEG alpha reactivity, which refers to the reduction in alpha power over occipital electrodes upon opening the eyes, has been suggested as a potential marker of cholinergic system integrity. Methods:Eyes-open and eyes-closed resting state EEG data were recorded from 41 LBD patients (including 24 patients with DLB and 17 with PDD), 21 patients with AD, and 40 age-matched healthy controls. Alpha reactivity was calculated as the relative reduction in alpha power over occipital electrodes when opening the eyes. Structural MRI data were used to assess volumetric changes within the NBM using a probabilistic anatomical map. Results: Alpha reactivity was reduced in AD and LBD patients compared to controls with a significantly greater reduction in LBD compared to AD. Reduced alpha reactivity was associated with smaller volumes of the NBM across all groups (ρ = 0.42, p FDR = 0.0001) and in the PDD group specifically (ρ = 0.66, p FDR = 0.01). Conclusions:We demonstrate that LBD patients show an impairment in alpha reactivity upon opening the eyes which distinguishes this form of dementia from AD. Furthermore, our results suggest that reduced alpha reactivity might be related to a loss of cholinergic drive from the NBM, specifically in PDD.

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Section: Discussionmentioning

confidence: 99%

Section: Alpha Reactivity Analysismentioning

confidence: 99%

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

et al. 2020

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“…In particular, previous studies focused on the shifting of the dominant frequency (DF) towards slower frequencies. These studies showed that the frequency with the most prominent peak in the power spectrum moves towards a lower range of frequencies in patients when compared with healthy controls (Bonanni et al, ; Peraza et al, ; Stylianou et al, ). DLB related changes were also found by EEG network connectivity studies.…”

Section: Introductionmentioning

confidence: 99%

“…The overlapping causes and symptoms often lead scientists to consider these two diseases as a sole group when aiming to assess effective biomarkers for the diagnosis of dementia (Lippa et al, 2007). However, due to enhanced cognitive dysfunction preceding the motor symptoms in DLB pathology, as well as a greater accumulation of amyloid in DLB (Edison et al, 2008), physiological differences and biomarkers to differentiate DLB and PDD remain a research question and might provide further insight on the development of the two subtypes (Stylianou et al, 2018). Electroencephalography (EEG) is emerging as a convenient technique in dementia research.…”

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confidence: 99%

“…Previous studies using eyes-closed resting state experimental protocol concur with the slowing of the α (alpha, 8-14 Hz) activity towards lower frequencies in DLB and PDD when compared with HC and AD. This characteristic emerges mostly in the occipital lobe (Andersson, Hansson, Minthon, Rosen, & Londos, 2008;Bonanni et al, 2015;Briel et al, 1999;Jackson & Snyder, 2008;Kai, Asai, Sakuma, Koeda, & Nakashima, 2005;Peraza et al, 2018;Stylianou et al, 2018). In particular, previous studies focused on the shifting of the dominant frequency (DF) towards slower frequencies.…”

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Weighted network measures reveal differences between dementia types: An EEG study

Mehraram

Kaiser

Cromarty

et al. 2019

Human Brain Mapping

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The diagnosis of dementia with Lewy bodies (DLB) versus Alzheimer's disease (AD) can be difficult especially early in the disease process. However, one inexpensive and non‐invasive biomarker which could help is electroencephalography (EEG). Previous studies have shown that the brain network architecture assessed by EEG is altered in AD patients compared with age‐matched healthy control people (HC). However, similar studies in Lewy body diseases, that is, DLB and Parkinson's disease dementia (PDD) are still lacking. In this work, we (a) compared brain network connectivity patterns across conditions, AD, DLB and PDD, in order to infer EEG network biomarkers that differentiate between these conditions, and (b) tested whether opting for weighted matrices led to more reliable results by better preserving the topology of the network. Our results indicate that dementia groups present with reduced connectivity in the EEG α band, whereas DLB shows weaker posterior–anterior patterns within the β‐band and greater network segregation within the θ‐band compared with AD. Weighted network measures were more consistent across global thresholding levels, and the network properties reflected reduction in connectivity strength in the dementia groups. In conclusion, β‐ and θ‐band network measures may be suitable as biomarkers for discriminating DLB from AD, whereas the α‐band network is similarly affected in DLB and PDD compared with HC. These variations may reflect the impairment of attentional networks in Parkinsonian diseases such as DLB and PDD.

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EEG Analysis of Neurodegenerative Diseases

2021

EEG Signal Processing and Machine Learning

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Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis

Cited by 48 publications

References 61 publications

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

Weighted network measures reveal differences between dementia types: An EEG study

EEG Analysis of Neurodegenerative Diseases

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