Antitumor Effect of Pomolic Acid in Acute Myeloid Leukemia Cells Involves Cell Death, Decreased Cell Growth and Topoisomerases Inhibition

Pereira, Michelle X.G.; Hammes, Amanda S.O.; Vasconcelos, Flavia da Cunha; Pozzo, Aline Rangel; Pereira, Thaís H.; Caffarena, Ernesto R.; Gattass, Cerli Rocha; Maia, Raquel Ciuvalschi

doi:10.2174/1871520618666180412120128

Cited by 2 publications

(3 citation statements)

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“…However, PA down-modulated MRP1/ABCC1 activity in both PC3 and PC3R cell lines, thus suggesting that this mechanism is responsible for PA’s cytotoxicity observed in both cell lines [ 225 ]. In acute myeloid leukemia cell lines HL60, U937, and Kasumi-1, PA decreased cell viability and cell growth and induced cell death via the activation of the caspase pathway and inhibition of hTopo I and IIα human DNA topoisomerases in all cell lines [ 10 ].…”

Section: Pomolic Acidmentioning

confidence: 99%

“…Triterpenes are well-represented phytocompounds with over 30,000 representants [ 7 ] that have received increased attention as a result of various biological properties, including anticancer, anti-inflammatory, hepatoprotective, antiviral, cardioprotective, and antimicrobial effects [ 8 ]. Among them, some triterpenic acids have been found to exert selective antiproliferative effects triggered mainly by apoptotic-dependent mechanisms [ 9 , 10 , 11 , 12 ]. Despite their remarkable properties, their lipophilic core imprints unfavorable physical-chemical properties that greatly hamper their bioavailability and consequent development as therapeutic drugs [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Mioc

Prodea

Racoviceanu

et al. 2022

IJMS

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Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic, antiviral, and antiparasitic effects. They are a subclass of triterpenes bearing a characteristic lipophilic structure that imprints unfavorable in vivo properties which subsequently limit their applications. The early investigation of the mechanism of action (MOA) of a drug candidate can provide valuable information regarding the possible side effects and drug interactions that may occur after administration. The current paper aimed to summarize the most recent (last 5 years) studies regarding the MOA of betulinic acid, boswellic acid, glycyrrhetinic acid, madecassic acid, moronic acid, and pomolic acid in order to provide scientists with updated and accessible material on the topic that could contribute to the development of future studies; the paper stands as the sequel of our previously published paper regarding the MOA of triterpenic acids with therapeutic value. The recent literature published on the topic has highlighted the role of triterpenic acids in several signaling pathways including PI3/AKT/mTOR, TNF-alpha/NF-kappa B, JNK-p38, HIF-α/AMPK, and Grb2/Sos/Ras/MAPK, which trigger their various biological activities.

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Section: Pomolic Acidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Mioc

Prodea

Racoviceanu

et al. 2022

IJMS

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show abstract

“…We previously isolated many compounds from the flowers of A. satureioides , including triterpenics, anthraquinones, and flavonoids. Research has shown that pomolic acid (PA) and its glucopyranose ester have effects against breast cancer[ 8 - 10 ], prostate cancer[ 11 ], leukemia[ 12 - 15 ], and other malignant tumors. Because of its high safety, these agents have been increasingly used in the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

Pomolic acid and its glucopyranose ester promote apoptosis through autophagy in HT-29 colon cancer cells

Liu,

Yu,

Liao

et al. 2023

World J Gastrointest Oncol

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Minimally invasive surgery is increasingly indicated in the management of malignant disease. Although oesophagectomy is a difficult operation, with a long learning curve, there is actually a shift towards the laparoscopic/thoracoscopic/ robotic approach, due to the advantages of visualization, surgeon comfort (robotic surgery) and the possibility of the whole team to see the operation as well as and the operating surgeon. Although currently there are still many controversial topics, about the surgical treatment of patients with gastro-oesophageal junction (GOJ) adenocarcinoma, such as the type of open or minimally invasive surgical approach, the type of oesophago-gastric resection, the type of lymph node dissection and others, the minimally invasive approach has proven to be a way to reduce postoperative complications of resection, especially by decreasing pulmonary complications. The implementation of new technologies allowed the widening of the range of indications for this type of surgical approach. The short-term and long-term results, as well as the benefits for the patient - reduced surgical trauma, quick and easy recovery - offer this type of surgical treatment the premises for future development. This article reviews the updates and perspectives on the minimally invasive approach for GOJ adenocarcinoma.

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Antitumor Effect of Pomolic Acid in Acute Myeloid Leukemia Cells Involves Cell Death, Decreased Cell Growth and Topoisomerases Inhibition

Abstract: Finally, this study showed that PA has powerful antitumor activity against AML cells suggesting that this natural compound might be a potent antineoplastic agent to improve the treatment scheme of this neoplasm.

Cited by 2 publications

References 0 publications

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Pomolic acid and its glucopyranose ester promote apoptosis through autophagy in HT-29 colon cancer cells

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