“…It was reported that depressive patients harbored different profiles of the HPA axis, which might be due to a feature of the NR3C1 DNAm (Malhi and Mann, 2018). Furthermore, demographic characteristics (i.e., age and gender), types and severity of ELS (physical abuse, sexual abuse, emotional abuse, physical and emotional neglects), tissue specificity (i.e., subregions of the brain, blood), dynamic changes in epigenetic profiles (interacting with continuous environment actions), and study design contributed to this discrepancy (McGowan et al, 2009;Perroud et al, 2011;Kember et al, 2012;Bustamante et al, 2016;Cecil et al, 2016;Tyrka et al, 2016;Alexander et al, 2018;Palma-Gudiel et al, 2018;Peng et al, 2018;Fiacco et al, 2019). Besides, because research focusing on the figure of histone modification and noncoding RNA within NR3C1 is lacking, it is unknown whether DNAm, histone modification, and non-coding RNA coordinate or disintegrate with each other.…”