Maternal periodontal disease and adverse perinatal outcomes: is there an association? A hospital-based case-control study

Krüger, Marta Silveira da Mota; Casarin, Renata Picanço; Pinto, Gabriela dos Santos; Pappen, Fernanda Geraldo; Camargo, Maria Beatriz Junqueira de; Corrêa, Fernanda Oliveira Bello; Romano, Ana Regina

doi:10.1080/14767058.2018.1464554

Cited by 18 publications

(21 citation statements)

References 36 publications

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“…23,24,25 In fact, a recent study reported no association between the clinical periodontal parameters analyzed and the perinatal outcome. 26 To understand the differences between the data obtained in Chile and Brazil, it is necessary to consider that the Chilean population is an ethnically and demographically more homogenous population than the Brazilian population, and that Chilean women receive a uniform and well-designed prenatal care program regulated by the Government. Perhaps a more important aspect to bear in mind is that Chilean women have been reported to have more severe periodontitis than women of the other Latin American countries.…”

Section: Impact Of Periodontal Disease On Other Diseasesmentioning

confidence: 99%

Periodontal disease and its impact on general health in Latin America. Section II: Introduction part II

et al. 2020

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Section: Impact Of Periodontal Disease On Other Diseasesmentioning

confidence: 99%

Periodontal disease and its impact on general health in Latin America. Section II: Introduction part II

et al. 2020

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“…Os coeficientes Kappa interexaminadores foram de 1 (para a fase de leitura de títulos e resumos) e 0,90 (para a fase de leitura do texto na íntegra). Entre os 15 artigos utilizados no levantamento bibliográfico, três eram estudos transversais [4,18,27], oito caso controle [13,16,21,24,26,30,37,42], dois de coorte prospectivos [5,45] e dois ensaios clínicos randomizados [6,34]. Os estudos foram conduzidos em nove países: África do Sul, Brasil, Colômbia, Espanha, Hungria, Itália, Irã, Tanzânia e Turquia.…”

Section: Resultsunclassified

“…Cerca de dez estudos apontaram para associação entre os indicadores clínicos periodontais, as alterações no tempo gestacional e o crescimento intrauterino [4,13,18,21,24,27,34,37,45], no entanto cinco outras pesquisas falharam em demonstrar tal associação [5,6,16,30,42]. Todos os artigos foram organizados segundo autor(es), país, desenho do estudo/descrição da amostra, critérios de diagnóstico para periodontite e conclusão (Tabela II).…”

Section: Resultsunclassified

Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Vieira¹,

Magalhães²,

Chaves³

et al. 2021

RSBO

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Revisar a literatura sobre a associação da doença periodontal com prematuridade e com baixo peso ao nascer. Material e métodos: No banco de dados PubMed e Google Scholar, utilizando a seguinte combinação de palavras: “Periodontal Diseases” [Majr] AND (Prematurity OR Low Birth Weight), foi realizada uma revisão integrativa da literatura envolvendo estudos humanos publicados no período de 2015 a 2020, avaliando a associação entre doença periodontal e prematuridade/baixo peso ao nascer. Resultados: A busca eletrônica resultou num total de 352 referências, reduzidas aos critérios de estudos humanos a 343, ao período a 53 e à leitura de títulos e resumos a 16. Após leitura da íntegra dos 16 artigos, foram selecionados 15 para o presente estudo, entre os quais três são estudos transversais, oito caso controle, dois estudos de coorte prospectivos e dois ensaios clínicos randomizados com resultados divergentes para tal associação. Conclusão: A maioria dos estudos analisados considera a relação da doença periodontal com parto prematuro e baixo peso ao nascer. Há necessidade de medidas preventivas, padronização de métodos e pesquisas específicas para evitar os efeitos adversos gestacionais.

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“…However, conversely, some studies have reported nding no association between CP and preterm LBW, and that treatment for periodontitis had no effect on the prevention of LBW [55][56][57][58][59][60][61][62][63][64][65][66]. Furthermore, as LBW is related to numerous risk factors, such as the mother's age, onset of prenatal care, systemic diseases, previous LBW infants, complications during pregnancy, and term of delivery, CP may not be an important risk factor for LBW [23][24][25][26][27]67]. Thus, the precise association between CP and LBW remains unclear.…”

Section: Discussionmentioning

confidence: 96%

“…The pathogenic bacterium of CP and chemical mediators produced by in ammation in gingiva were considered to penetrate into weak capillary blood vessels, and then to cord blood through the placenta [2][3][4]. Some researchers have reported that CP in uences the development of LBW [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], whereas others have denied such an association [23][24][25][26][27]. Therefore, no consensus has been reached on the association between CP and LBW [28][29][30][31], and more studies are needed to address this issue.…”

Section: Introductionmentioning

confidence: 99%

Potential Common Key Genes Associated with Chronic Periodontitis and Low Birth Weight: A Case Control Study Using Bioinformatics Analysis of Pooled mRNA Expression Datasets

Suzuki

Horie

Nakai³

et al. 2020

Preprint

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Background: Chronic periodontitis (CP) is a multifactorial disease associated with many systemic diseases. However, the precise association between CP and low birth weight (LBW) remains unclear. Therefore, this study aimed to elucidate common differentially expressed genes (DEGs), biomarker candidates, and upstream regulators related to key genes between CP and LBW.Methods: We investigated molecular relations and biomarker candidates using pooled microarray datasets of CP (GSE12484) and LBW (GSE29807) in the Gene Expression Omnibus (GEO). Datasets were analyzed for common DEGs using GEO2R, an R-based web application for GEO data analysis. Common DEGs, biomarker candidates, and upstream regulators in DEGs between CP and LBW were analyzed using the Database for Annotation Visualization and Integrated Discovery (DAVID), Search Tool for the Retrieval of Interacting Genes (STRING), and QIAGEN’s Ingenuity Pathway Analysis (IPA).Results: Three significantly upregulated and 20 significantly downregulated common DEGs between CP and LBW were identified. Some biological processes and pathways of these downregulated genes were associated with the cell cycle. Biomarker candidates among common DEGs were proline-rich coiled-coil 2A (PPRC2A), topoisomerase (DNA) II alpha (TOP2A), neural cell adhesion molecule 1 (NCAM1), and calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3). Many upstream regulators of these biomarker candidates were factors associated with inflammation, immunity, the cell cycle, and growth development, and were hormones related to pregnancy.Conclusions: The results of this study suggest that PPRC2A, TOP2A, NCAM1, and CACNA2D3 are common biomedical key genes between CP and LBW. The expression states of these genes, which are related to inflammation, hormones, the cell cycle, and growth development, were common in both CP and LBW in blood. To the best of our knowledge, the relations of PPRC2A, TOP2A, and CACNA2D3 to CP and LBW are reported for the first time. Thus, in the bloodstream, inflammatory-related upstream regulators of these key genes may control gene expression associated with fetal growth, and conversely, changes in female hormones due to pregnancy may affect the progress of CP.

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Maternal periodontal disease and adverse perinatal outcomes: is there an association? A hospital-based case-control study

Abstract: The present study demonstrated no association between maternal periodontitis and PTB/LBW.

Cited by 18 publications

References 36 publications

Periodontal disease and its impact on general health in Latin America. Section II: Introduction part II

Periodontal disease and its impact on general health in Latin America. Section II: Introduction part II

Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Potential Common Key Genes Associated with Chronic Periodontitis and Low Birth Weight: A Case Control Study Using Bioinformatics Analysis of Pooled mRNA Expression Datasets

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