Protective roles and mechanisms of polysaccharides from Dendrobium officinal on natural aging-induced premature ovarian failure

Wu, Yayun; Liang, Chuyan; Liu, Tingting; Liang, Yingmin; Li, Shijie; Lu, Yang; Liang, Jian; Yuan, Xin; Chu-jie, LI; Hou, Shaozhen; Lai, Xiaoping

doi:10.1016/j.biopha.2018.03.030

Cited by 32 publications

(23 citation statements)

References 28 publications

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“…The activation of p21 protein could block the progression of cells from G1 to the S phase, causing a transient cell cycle arrest and ultimately cellular senescence [ 115 ]. It was found that oral administration of DOPs reduced p53 expression and increased Bcl-2 expression in the ovaries of aging mice, thereby treating premature ovarian failure due to natural aging [ 116 ]. Injections of ASPs reduced the expression of p53 and p21 proteins in mice [ 59 ], and gavage of MPP reduced the expression of p21 and p53 proteins in the liver and brain of aging mice, thereby delaying cellular aging [ 64 ].…”

Section: Polysaccharides and Aging-related Signal Pathwaysmentioning

confidence: 99%

“…Dendrobium officinal (70 mg/kg) Female mice Alleviated damage caused by aging through the inhibition of the nuclear NF-κB and p53/Bcl-2mediated signaling pathways [116] Angelica polysaccharide (140 mg/kg) Nestin-GFP transgenic mouse brain tissues and neural stem cells Delayed aging speed by protecting neural stem cells and upregulating the p53/p21 signaling pathway [59] Yulangsan polysaccharide (0.6 g/kg) D-Galactose-treated mice Suppressed the aging process by decreasing p21 and p53 gene expressions in the liver and brain [64] Notes: AMPK: adenosine monophosphate-activated protein kinase; ERK: extracellular signal-regulated kinase; FGF21: fibroblast growth factor 21; PPAR: peroxisome proliferator-activated receptor; PI3K: phosphatidyl inositol 3-kinase; AKT: protein kinase B; ROS: reactive oxygen species; SIRT: sirtuin; mTOR: the mammalian target of rapamycin; NAFLD: nonalcoholic fatty liver disease; LPS: lipopolysaccharides; NO: nitric oxide; AMPK: adenosine monophosphate-activated protein kinase; PGC: primordial germ cell; MDA: malondialdehyde; GSH-PX: glutathione peroxidase; HIF: hypoxiainducible factor. 9 Oxidative Medicine and Cellular Longevity intracellular mTOR are mTORC1 and mTORC2.…”

Section: Polysaccharides Frommentioning

confidence: 99%

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Antiaging Effects of Dietary Polysaccharides: Advance and Mechanisms

Han

Huang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Aging is a process in which the various physiological functions of the body gradually deteriorate and eventually lead to death. During this process, the body’s resistance to external stresses gradually decreases and the aging-related diseases gradually are increased. Polysaccharides are a group of active substances extracted from living organisms and are widely found in plants, animals, and microorganisms. In the last decade, a variety of natural polysaccharides from functional and medicinal foods have attracted considerable interest for their beneficial effects in the prevention of chronic diseases such as cancers, diabetes, and neurodegenerative diseases. Interestingly, these polysaccharides have also been found to delay aging by reducing oxidative damage, inhibiting telomere shortening, and being anti-inflammatory in different animal models of aging. These reviews summarized the progresses in effects of polysaccharides on antiaging and the potential mechanisms and especially focused on the signaling pathways involved in the antiaging functions. Finally, the applications and prospects of the antiaging effects of polysaccharides are discussed.

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Section: Polysaccharides and Aging-related Signal Pathwaysmentioning

confidence: 99%

Section: Polysaccharides Frommentioning

confidence: 99%

Antiaging Effects of Dietary Polysaccharides: Advance and Mechanisms

Han

Huang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Another study was conducted on naturally aging mice with premature ovarian failure, the effects of polysaccharides from Dendrobium officinal (DOP) was found to inhibit the nuclear factor ‐κB (NF‐κB) and p53/Bcl‐2‐mediate signaling pathways, reducing damage caused by aging. In addition to increasing mitochondrial numbers and improving its membranes, also the number of different follicular cell stages was noticed to increase [118] . An increase in follicles and corpus luteum was noticed to improve in aging mice by polysaccharides of Fructus corni [119] .…”

Section: Polysaccharides In Endocrinologymentioning

confidence: 99%

Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

Khalid

Asim-ur-Rehman

Ahmed

et al. 2021

Chemistry A European J

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Polysaccharides, due to their outstanding properties, have attracted the attention of researchers, working in the biomedical field and especially of those working in drug delivery. Modified/functionalized polysaccharides further increase the importance for various applications. Delivery of therapeutics for diverse ailments in different endocrine glands and hormones safely, is a focal point of researchers working in the field. Among the routes followed, the transdermal route is preferred due to non‐exposure of active moieties to the harsh gastric environment and first‐pass metabolism. This review starts with the overview of polysaccharides used for the delivery of various therapeutic agents. Advantages of polysaccharides used in the transdermal route are addressed in detail. Types of polysaccharides will be elaborated through examples, and in this context, special emphasis will be on the polysaccharides being used for synthesis of the membranes/films. Techniques employed for their modification to design novel carriers for therapeutics delivery will also be discussed. The review will end with a brief discussion on recent developments and future perspectives for delivery of therapeutic agents, and vaccine development.

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“…The potential mechanism signaling pathway may work through regulating the nuclear factor-κB and p53/Bcl-2. 80 Zuogui Pills (ZGP) are a component in TCM used in the treatment of POF, increasing proliferation and decreasing apoptosis in the ovarian cells. 81 The therapeutic effects of ZGP on the treatment of POF due to chemotherapy were investigated by Peng et al They illustrated that the number of follicles, ovarian ultrastructures, and the estrous cycle notably ameliorated in rats with POF.…”

Section: Approaches To Fertility Preservation In Patients With Pof By Influencing the Function Of Mitochondriamentioning

confidence: 99%

The role of mitochondria in premature ovarian failure: A review

Khosravizadeh

Rashidi

Talebi

et al. 2020

J. Contemp. Med. Sci.

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Premature ovarian failure (POF) is used to describe women under 40 years old with amenorrhea, hypergonadotropic hypogonadism, and infertility as a result of cessation of ovarian function. It has been reported that almost 20% of women who consult for infertility have signs of premature ovarian ageing. The mitochondrial disorder is one of the critical agents in premature menopause and the occurrence of POF. Due to the maternal inheritance of POF along with the dependence of folliculogenesis upon the mitochondrial biogenesis and bioenergetics, it has been suggested that a generalized mitochondrial defect is likely involved in POF. A fuller understanding of the mitochondrial role in POF could contribute to the better management of women with POF in the future. The aim of this review was to illustrate the role of mitochondria in POF. The oocyte mitochondrial DNA (mtDNA) content in women with diminished ovarian reserve is significantly lower than in women with normal ovarian reserve. It has been evidenced that mitochondrial genetic disorders and mitochondrial oxidative stress are associated with POF. According to the maternal inheritance of mtDNA, genetic testing should be performed to detect mtDNA mutations involved in POF before starting treatment strategies. If these mutations are present, it could suggest that healthy mitochondrial transfer during ART should be used to prevent the transmission of POF caused by mtDNA mutation to the female offspring. Future strategies aimed at treatment of POF-related infertility should take into account the significance of the oocyte mitochondrial role in the occurrence of this disorder.

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Protective roles and mechanisms of polysaccharides from Dendrobium officinal on natural aging-induced premature ovarian failure

Cited by 32 publications

References 28 publications

Antiaging Effects of Dietary Polysaccharides: Advance and Mechanisms

Antiaging Effects of Dietary Polysaccharides: Advance and Mechanisms

Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

The role of mitochondria in premature ovarian failure: A review

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