2018
DOI: 10.1016/j.cbi.2018.04.005
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Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway

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Cited by 26 publications
(16 citation statements)
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“…Hinoi et al (58) found that the PI3K/Akt pathway could indirectly promote the nuclear translocation of PGC1α, which serves crucial roles in FA oxidation. Consistent with a previous study (59), the livers of HFD-fed hamsters in the present study exhibited a significant reduction in AMPK phosphorylation levels compared with the control group. Akt phosphorylation, as well as PPARα and PGC1α protein expression levels were also reduced in the model group compared with the control.…”
Section: Discussionsupporting
confidence: 93%
“…Hinoi et al (58) found that the PI3K/Akt pathway could indirectly promote the nuclear translocation of PGC1α, which serves crucial roles in FA oxidation. Consistent with a previous study (59), the livers of HFD-fed hamsters in the present study exhibited a significant reduction in AMPK phosphorylation levels compared with the control group. Akt phosphorylation, as well as PPARα and PGC1α protein expression levels were also reduced in the model group compared with the control.…”
Section: Discussionsupporting
confidence: 93%
“…[ 20 ] MiR-145 is correlated with the progression of various cancers by regulating the expression of multiple target genes, especially a number of genes that regulate angiogenesis and proliferation. [ 21 23 ] Our previous work showed that the expression of miR-145 was significantly lower in UM tissues than normal uveal samples. Overexpression of miR-145 suppressed cell proliferation by blocking cells in G1 phase from entering S phase and promoted cell apoptosis in UM cells.…”
Section: Discussionmentioning
confidence: 99%
“…It has been described that expression levels of IRS1 are modulated by miR-145 in hepatocytes [158] whereas in mice, upregulation of miR-145 in the liver leads to insulin resistance [159]. Atorvastatin treatment has also been shown to differentially upregulate miR-145 and modulates PI3K/Akt signaling pathway [160].…”
Section: Modulation Of the Insulin Signaling Pathwaymentioning
confidence: 99%