Effects of buprenorphine, butorphanol or tramadol premedication on anaesthetic induction with alfaxalone in common marmosets ( Callithrix jacchus )

Bakker, Jaco; Roubos, S.; Remarque, Edmond J.; Arndt, Saskia S.; Kronen, Peter W; Langermans, Jan A. M.

doi:10.1016/j.vaa.2017.06.009

Cited by 12 publications

(13 citation statements)

References 23 publications

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“…The decreased RR values (32–41 bpm) were similar to the reported RR in conscious marmosets at rest (36–44 bpm) (Horii et al, 2002) regardless of the propofol concentration, which suggested that respiratory depression was not profound when propofol was administered with the dose and infusion rate used in this study. RR values were also similar to these in other study using alfaxalone combinations (Bakker et al, 2018, 2013). Apnoea was not observed and SpO 2 was above 95% at most of the time points in Study 2, which indicated that the respiratory depressive effect of propofol was not profound.…”

Section: Discussionsupporting

confidence: 89%

“…HR (224–293 bpm) during time period that marmosets were immobilized in Study 2 were not very different from that in conscious marmosets at rest (200–250 bpm) or in sleeping marmosets (around 150 bpm) according to a previous study using telemetry (Schnell & Wood 1993) regardless of propofol concentration. HR values were also similar to these in other study using alfaxalone combinations (Bakker et al, 2018, 2013). It suggests that the depressive effect of propofol on HR is little when propofol is administrated at the dose and infusion rate used in this study; however, measuring other cardiovascular parameters such as arterial blood pressure, stroke volume and cardiac output are desirable in evaluating the cardiovascular effect of propofol accurately.…”

Section: Discussionsupporting

confidence: 89%

“…Propofol was also reported to have reinforced side effects when co‐administrated with opioids such as fentanyl (Gill, Wright, & Reilly, 1990; Lysakowski, Dumont, Pellégrini, Clergue, & Tassonyi, 2001; Reich et al, 2005). Bakker et al reported similar interaction between alfaxalone, which is a neuroactive steroid and general anaesthetic enhancing gamma‐aminobutyric acid sub‐type 1 receptor‐mediated neurotransmission, and several opioids and it supports this phenomenon of this study (Bakker et al, 2018). Therefore, it is likely that combinations of propofol and other drugs will result in profound respiratory depression in marmosets.…”

Section: Discussionsupporting

confidence: 85%

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Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Muta

Miyabe‐Nishiwaki

Masui

et al. 2020

Vet Pharm & Therapeutics

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The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8 mg/kg of propofol was administrated at a rate of 4 mg kg−1 min−1. Blood samples were collected 2, 5, 15, 30, 60, 90, 120 or 180 min after starting propofol administration. Plasma concentration was measured, and population pharmacokinetic modelling was performed. A two‐compartment model was selected as the final model. The population pharmacokinetic parameters were as follows: V1 = 1.14 L, V2 = 77.6 L, CL1 = 0.00182 L/min, CL2 = 0.0461 L/min. In Study 2, clinical and physiological parameters were assessed and recorded every 2 min after 12 mg/kg of propofol was administrated at a rate of 4 mg kg−1 min−1. Immobilization was sustained for 5 min following propofol administration without apparent bradycardia. While combination of propofol and sevoflurane caused apnoea in Study 1, apnoea was not observed following single administration of propofol in Study 2. These data provide bases for further investigation on intravenous anaesthesia using propofol in common marmosets.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Muta

Miyabe‐Nishiwaki

Masui

et al. 2020

Vet Pharm & Therapeutics

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“… 70 Similar effects have been observed when using propofol in marmosets, 49 with the effects of either agent being dose dependent. With isoflurane having only limited analgesic effects, additional analgesic medications (eg, nonsteroidal anti-inflammatory drugs such as meloxicam or opioids such as buprenorphine) 68 may be needed, especially if stereotactic devices with ear bars are used. Coating the tips of the ear bars with topical analgesics such as xylocaine jelly is also recommended.…”

Section: Mri Under Anesthesiamentioning

confidence: 99%

Magnetic Resonance Imaging of Marmoset Monkeys

et al. 2020

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The use of the common marmoset monkey (Callithrix jacchus) for neuroscientific research has grown markedly in the last decade. Magnetic resonance imaging (MRI) has played a significant role in establishing the extent of comparability of marmoset brain architecture with the human brain and brains of other preclinical species (eg, macaques and rodents). As a non-invasive technique, MRI allows for the flexible acquisition of the same sequences across different species in vivo, including imaging of whole-brain functional topologies not possible with more invasive techniques. Being one of the smallest New World primates, the marmoset may be an ideal nonhuman primate species to study with MRI. As primates, marmosets have an elaborated frontal cortex with features analogous to the human brain, while also having a small enough body size to fit into powerful small-bore MRI systems typically employed for rodent imaging; these systems offer superior signal strength and resolution. Further, marmosets have a rich behavioral repertoire uniquely paired with a lissencephalic cortex (like rodents). This smooth cortical surface lends itself well to MRI and also other invasive methodologies. With the advent of transgenic modification techniques, marmosets have gained significant traction as a powerful complement to canonical mammalian modelling species. Marmosets are poised to make major contributions to preclinical investigations of the pathophysiology of human brain disorders as well as more basic mechanistic explorations of the brain. The goal of this article is to provide an overview of the practical aspects of implementing MRI and fMRI in marmosets (both under anesthesia and fully awake) and discuss the development of resources recently made available for marmoset imaging.

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“…Common marmosets ( Callithrix jacchus ) are increasingly used in biomedical research, 1 particularly since the successful generation of transgenic marmosets 2 . While they are often anaesthetised for various procedures, published information on marmoset anaesthesia and analgesia is limited 3‐7 . Inhalation anaesthetics are preferred for both shorter and longer procedures.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anaesthetic and cardiorespiratory effects after intramuscular administration of alfaxalone alone, alfaxalone‐ketamine and alfaxalone‐butorphanol‐medetomidine in common marmosets (Callithrix jacchus)

Miyabe‐Nishiwaki

Miwa

Konoike

et al. 2020

J of Medical Primatology

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Common marmosets (Callithrix jacchus) are increasingly used in biomedical research, 1 particularly since the successful generation of transgenic marmosets. 2 While they are often anaesthetised for various procedures, published information on marmoset anaesthesia and analgesia is limited. 3-7 Inhalation anaesthetics are preferred for both shorter and longer procedures. However, there are some occasions when inhalation anaesthetics are not feasible, for example anaesthesia in the field, in the enclosure or in the home cage. Injectable anaesthetics may be considered as alternatives and even preferred under such conditions. Alfaxalone is a neuroactive steroid, activating gamma aminobutyric acid (GABA) receptors resulting in anaesthetic effects. 8

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Effects of buprenorphine, butorphanol or tramadol premedication on anaesthetic induction with alfaxalone in common marmosets ( Callithrix jacchus )

Cited by 12 publications

References 23 publications

Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Magnetic Resonance Imaging of Marmoset Monkeys

Evaluation of anaesthetic and cardiorespiratory effects after intramuscular administration of alfaxalone alone, alfaxalone‐ketamine and alfaxalone‐butorphanol‐medetomidine in common marmosets (Callithrix jacchus)

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