Moxifloxacin-induced tinnitus in an older adult

Abstract

An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacininduced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents. A thorough literature review provided few other reported incidents of this rare and serious adverse event.

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

“…Antibiotics (aminoglycosides, tetracycline, macrolides, quinolones, vancomycin, metronidazole) 159–164 …”

Determination of moxifloxacin in milk using a ratiometric fluorescent sensor based on Ag-MOF@curcumin

“…11,12 Moxi-oxacin (MFX), a uoroquinolone antibiotic, can be used to treat pneumonia, skin and skin structure infections, and increases heart rate in humans, 13 but a survey also showed that MFX can induce tinnitus in older adults. 14 Therefore, it is very necessary to establish an effective MFX determination method, especially for the analysis of MFX content in food and water.…”