Transport kinetics of chromium in perfused human placental lobule in late gestation:<i>in vitro</i>study

Al-Sannan, Baydaa; Nandakumaran, Moorkath; Al-Harmi, Jehad; Al-Shammari, Majed; Fouda, Mohamed A.

doi:10.1080/14767058.2018.1454425

Cited by 2 publications

(3 citation statements)

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“…Further studies with specific inhibitors may differentiate the role of D3 and SULTs in placental metabolism and transfer of iodothyronines. Finally, future study with in vitro perfused human placental lobule, that is collected and prepared immediately after delivery from normal uncomplicated pregnancy, may be more relevant to humans [34].…”

Section: Discussionmentioning

confidence: 99%

Maternal 3,3’-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3’,5-Triodothyronine

Wu¹,

Emerson²,

Tjioe³

et al. 2021

JED

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Objective: Serum 3, 3’,5-triiodothyronine (T3) remains low in near-term fetus to prevent the growing fetus from undue exposure to its active catabolic effect in mammals. The present study was undertaken to gain insight in the role of placenta in T3 metabolism, fetal to maternal transfer of T3, and its metabolites by in situ placenta perfusion with outer-ring labeled [125I]-T3 in pregnant guinea pig, a species showing increased sulfated 3, 3’-diiodothyronine (T2S) levels in maternal serum in late pregnancy (term = 65 days), similarly to humans in pregnancy. Materials and Methods: One-pass placenta perfusions performed on pregnant guinea pigs were studied between 58 - 65 days of gestation. In two separate experiments, the umbilical artery of the guinea pig placenta was perfused in situ at 37°C with outer-ring labeled [125I]-T3. Maternal sera and umbilical effluents were obtained for analysis at the end of a 60-minute perfusion, when the steady-state levels of radioactivity were reached in the placenta effluent after 30-minute. Results: Sulfated [125I]-T2S was readily detected in the maternal serum as the major metabolite of T3 following the perfusion of placenta with [125I]-T3, suggesting that placental inner-ring deiodinase and sulfotransferase may play an important role in fetal T3 homeostasis and in the fetal to maternal transfer of sulfated iodothyronine metabolites. Conclusions: The expression of type 3 deiodinase (D3) and thyroid hormone sulfotransferase activity in placenta may play an important role to protect developing organs against undue exposure to active thyroid hormone in late gestation in the fetus. The combined activities of D3 and sulfotransferase promoted a placental transfer of T2S into maternal circulation. The maternal circulation of T2S is fetal T3 in origin and its role as a fetal thyroid function biomarker deserves further evaluations and studies.

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Section: Discussionmentioning

confidence: 99%

Maternal 3,3’-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3’,5-Triodothyronine

Wu¹,

Emerson²,

Tjioe³

et al. 2021

JED

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“…Despite this fact, literature about Cr in newborns is rare and mostly based on discovering the impact of high exposure to environmental Cr in pregnant women and the impact on babies' health. [1][2][3] Research about Cr levels in preterm infants receiving parenteral nutrition is very scarce. [4][5] The transition element Chromium (Cr) exists in several oxidation states.…”

Section: Introductionmentioning

confidence: 99%

“…Bivariate associations between numeric variables and plasma Cr levels adjusted for PN and BW Spearman's rank correlation coe cient (Spearman's Rho) to analyze the association between two continuous variables3 Associations were adjusted by newborns' gestational age and days of PN using linear regression analysis with Cr levels as dependent variable. Simple regressions are expressed by crude Beta coe cient (B) and multiple regressions by Adjusted Beta coe cient.…”

mentioning

confidence: 99%

Chromium-free parenteral nutrition and their effects on chromium levels in very low birth weight infants

Tejedor,

Vetter-Laracy,

Cobo

et al. 2024

Preprint

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Background As Chromium (Cr) is known to contaminate components of parenteral nutrition (PN), Cr-free PN is recommended for preterm infants. Exposure to Cr by PN in preterm infants is scarcely investigated. Objective To describe Cr levels in plasma (Crp) and urine (Cru) during the first month of life in premature newborns ≤ 1500 g of birthweight (BW) receiving PN and to evaluate the impact on postnatal clinical parameters. Methods A prospective observational study. Cr-free PN was administered at day 1 of life and continued until full enteral feeding with fortified breastmilk began. Crp levels at day 15 and 30 and Cru at day 30 of life were assessed according to demographic factors, biochemical markers and postnatal morbidity. Results 97 infants had a median gestational age (GA) of 29.9 weeks, and median BW of 1205g. Medium Crp remained at 1.0 µg/L at 15 and 30 days (IQR 0.7–1.4 and 0.7–1.3 respectively). Premature babies < 26 weeks had a significantly higher Crp at one month than the remainder (P = 0.043) and a higher Cr elimination in urine (P = .026). Crp increased with prolonged PN (P < 0.001), even after adjusting for gestational age (P = .001). Laboratory parameters were not influenced by Crp or Cru, nor was morbidity. Conclusion Crp increases with days of PN even when a trace mineral supplement without Cr is used and the level reached maintains during the first month of life with the introduction of Cr supplemented breastmilk feeding. No relation to morbidity was observed.

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Transport kinetics of chromium in perfused human placental lobule in late gestation:in vitrostudy

Cited by 2 publications

References 30 publications

Maternal 3,3’-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3’,5-Triodothyronine

Maternal 3,3’-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3’,5-Triodothyronine

Chromium-free parenteral nutrition and their effects on chromium levels in very low birth weight infants

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