Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer

Steel, Jennifer L.; Terhorst, Lauren; Collins, Kevin P; Geller, David A.; Vodovotz, Yoram; Kim, Juliana; Krane, Andrew; Antoni, Mike; Marsh, J. Wallis; Burke, Lora E.; Butterfield, Lisa H.; Penedo, Frank J.; Buysse, Daniel J.; Tsung, Allan

doi:10.1097/psy.0000000000000579

Cited by 31 publications

(19 citation statements)

References 68 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-1 plays a key role in carcinogenesis and tumor growth [ 193 ], due to its importance as a key downstream mediator of inflammation [ 194 ]. Increased levels of IL-1β in body fluids are correlated in experimental tumor models and in cancer patients with bad prognosis, carcinogenesis and invasiveness of the tumor [ 195 , 196 , 197 ].…”

Section: Role Of Il-1β In Tumor Developmentmentioning

confidence: 99%

“…Increased levels of IL-1β in body fluids are correlated in experimental tumor models and in cancer patients with bad prognosis, carcinogenesis and invasiveness of the tumor [ 195 , 196 , 197 ]. The key mechanisms by which IL-1β promotes tumor development are driving chronic non-resolved inflammation [ 193 ], endothelial cell activation [ 194 ], tumor angiogenesis [ 195 ] and induction of immunosuppressive cells ( Figure 3 ). Altogether, these mechanisms account for suppression of the adaptive immunity, tumor promotion and metastasis [ 193 ].…”

Section: Role Of Il-1β In Tumor Developmentmentioning

confidence: 99%

“…As outlined above, inhibition of IL-1β signaling by using appropriate mouse models was shown to influence multiple key mechanisms of tumor growth such as chronic inflammation that triggered tumor development [ 193 ], accumulation of immunosuppressive cells in the tumor milieu [ 194 ], angiogenesis [ 195 ] within the tumor microenvironment, and metastasis [ 196 ]. Therefore, blockade of IL-1β may constitute an important therapeutic rationale to impair tumor development and progression.…”

Section: Inhibition Of Il-1 Signaling Inhibits Tumor Growthmentioning

confidence: 99%

See 2 more Smart Citations

Interleukin-1 Beta—A Friend or Foe in Malignancies?

Bent

Moll

Grabbe

et al. 2018

IJMS

300

221

View full text Add to dashboard Cite

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial role in resolving acute inflammations, and by initiating adaptive anti-tumor responses. However, IL-1β generated in the course of chronic inflammation supports tumor development. Furthermore, IL-1β generated within the tumor microenvironment predominantly by tumor-infiltrating macrophages promotes tumor growth and metastasis via different mechanisms. These include the expression of IL-1 targets which promote neoangiogenesis and of soluble mediators in cancer-associated fibroblasts that evoke antiapoptotic signaling in tumor cells. Moreover, IL-1 promotes the propagation of myeloid-derived suppressor cells. Using genetic mouse models as well as agents for pharmacological inhibition of IL-1 signaling therapeutically applied for treatment of IL-1 associated autoimmune diseases indicate that IL-1β is a driver of tumor induction and development.

show abstract

Section: Role Of Il-1β In Tumor Developmentmentioning

confidence: 99%

Section: Role Of Il-1β In Tumor Developmentmentioning

confidence: 99%

Section: Inhibition Of Il-1 Signaling Inhibits Tumor Growthmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin-1 Beta—A Friend or Foe in Malignancies?

Bent

Moll

Grabbe

et al. 2018

IJMS

300

221

View full text Add to dashboard Cite

show abstract

“…165,166 For example, insomnia associated with cancer has been linked to decreased quality of life, 165 impaired immune function, 167,168 cancer-related fatigue, 169 and may have implications for tumor progression [170][171][172] and greater mortality risk. 173 These secondary medical conditions (eg, sleep disruption) can aggravate inflammatory processes and stimulate the release of central cytokines, which act to alter neuronal plasticity and brain functioning, affecting peripheral biobehavioral processes such as the activation of the HPA axis and the SNS, resulting in the production of high levels of cortisol. Thus, stress management interventions might help to reduce, mitigate, or prevent chemobrain syndrome indirectly by mitigating the risk of and effects of comorbidity or multimorbidity.…”

Section: Distress Management Effects On Comorbiditymentioning

confidence: 99%

“…Depression, fatigue, sleep disturbances, and cognitive dysfunction are common in cancer patients and have an adverse impact on quality of life and cancer survival 165 , 166 . For example, insomnia associated with cancer has been linked to decreased quality of life, 165 impaired immune function, 167 , 168 cancer-related fatigue, 169 and may have implications for tumor progression 170 – 172 and greater mortality risk 173 …”

Section: Effects Of Psychological Interventions On Biobehavioral Procmentioning

confidence: 99%

Emotional distress, brain functioning, and biobehavioral processes in cancer patients: a neuroimaging review and future directions

2019

View full text Add to dashboard Cite

Despite emerging evidence that distress and adversity can contribute to negative health outcomes in cancer, little is known about the brain networks, regions, or circuits that can contribute to individual differences in affect/distress states and health outcomes in treated cancer patients. To understand the state-of-the-science in this regard, we reviewed neuroimaging studies with cancer patients that examined the associations between negative affect (distress) and changes in the metabolism or structure of brain regions. Cancer patients showed changes in function and/or structure of key brain regions such as the prefrontal cortex, thalamus, amygdala, hippocampus, cingulate cortex (mainly subgenual area), hypothalamus, basal ganglia (striatum and caudate), and insula, which are associated with greater anxiety, depression, posttraumatic stress disorder (PTSD) symptoms, and distress. These results provide insights for understanding the effects of these psychological and emotional factors on peripheral stress-related biobehavioral pathways known to contribute to cancer progression and long-term health outcomes. This line of work provides leads for understanding the brain-mediated mechanisms that may explain the health effects of psychosocial interventions in cancer patients and survivors. A multilevel and integrated model for distress management intervention effects on psychological adaptation, biobehavioral processes, cancer pathogenesis, and clinical outcomes is proposed for future research.

show abstract

Sleep Composition of Patients With Colorectal Cancer and Their Sleep‐Partner Caregivers: Physical Health Correlates of Sleep Diary and Actigraphy Measurements

Ting,

Tsai,

Zeitzer

et al. 2024

Psycho-Oncology

View full text Add to dashboard Cite

BackgroundDisturbed sleep is frequently identified in adult patients with cancer and their caregivers, with detrimental impact on physical health. Less known is the extent to which self‐reported and actigraph‐measured sleep patterns are similar between patients and their sleep‐partner caregivers, and how these different modes of sleep measurements are related to physical health.MethodsPatients diagnosed with colorectal cancer and their sleep‐partner caregivers (81 dyads) completed a questionnaire for physical functioning and collected saliva samples for seven consecutive days, from which cortisol slope was quantified. Additionally, participants completed a daily sleep diary and wore actigraph for 14 consecutive days, from which sleep duration, sleep onset latency (SOL), and duration of wake after sleep onset (WASO) were calculated.ResultsParticipants reported sleep patterns that fell within or close to the optimal range, which were similar between patients and their caregivers. Self‐reported and actigraph‐measured sleep duration had moderate levels of agreement (ICC = 0.604), whereas SOL and WASO had poor agreement (ICC = 0.269). Among patients, longer self‐reported WASO was associated with poorer physical health and flatter cortisol slope (p ≤ 0.013). Among caregivers, longer self‐reported SOL was associated with poorer physical functioning, actigraph‐measured WASO was associated with steeper cortisol slope, and longer self‐reported sleep markers studied than actigraph‐measured were associated with poorer physical functioning (p ≤ 0.042).ConclusionFindings suggest that employing multiple assessment modes for sleep and physical health is vital for comprehensive understanding of sleep health. Furthermore, when addressing patients' sleep health, it may be beneficial to include their sleep‐partner caregivers who may experience similar disturbed sleep.

show abstract

Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer

Abstract: Sleep duration was associated with symptom burden and poorer survival and IL-2 was found to mediate the association between sleep and survival. Screening and treatment of sleep problems in patients diagnosed with cancer are warranted.

Cited by 31 publications

References 68 publications

Interleukin-1 Beta—A Friend or Foe in Malignancies?

Interleukin-1 Beta—A Friend or Foe in Malignancies?

Emotional distress, brain functioning, and biobehavioral processes in cancer patients: a neuroimaging review and future directions

Sleep Composition of Patients With Colorectal Cancer and Their Sleep‐Partner Caregivers: Physical Health Correlates of Sleep Diary and Actigraphy Measurements

Contact Info

Product

Resources

About