Did Cro-Magnon 1 have neurofibromatosis type 1?

Charlier, Philippe; Benmoussa, Nadia; Froesch, Philippe; Huynh-Charlier, Isabelle; Balzeau, Antoine

doi:10.1016/s0140-6736(18)30495-1

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…The demographic profile observed at the Cro-Magnon rock-shelter, with the association of elderly adults and very young children (under one year of age) thus appears unusual for the Gravettian, and suggests selective funerary practices, perhaps related to perceptions of similar levels of vulnerability. The presence of at least one adult, and possibly one infant, displaying visible signs of disease (Charlier et al, 2018), reinforces this hypothesis, as has been suggested for the burial of other Gravettian impaired individuals (Oliva, 1996;Formicola, 2007). An additional intriguing aspect, which could be coincidental, is that the number of children is of the same order as the number of adults at Cro-Magnon.…”

Section: Mup Burial Age Distribution and Age Selection At Cro-magnonsupporting

confidence: 75%

“…However, this question remains of interest considering the abundance of developmental anomalies in the Pleistocene fossil record (Trinkaus, 2018), to the point that they may indicate a high level of inbreeding (Wu et al, 2013;Ríos et al, 2015;Sparacello et al, 2018;Trinkaus, 2018). If the individual to whom CM 4252-5 belonged had abnormalities evident to the social group, as was the case for Cro-Magnon 1 whose skeletal lesions indicate a systemic and rare disease (Dastugue, 1967;Thillaud, 1985;Charlier et al, 2018;Ruggieri et al, 2018;Thibeault and Villotte, 2018), this condition may have played an important role in group behavior towards him/her, and particularly after his/her death. As previously noted (Oliva, 1996;Formicola 2007;Trinkaus et al, 2014), Gravettian burials contain an unusually high number of individuals with both developmental and degenerative conditions.…”

Section: The Case Of the CM 4252-5 Femurmentioning

confidence: 99%

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The Cro-Magnon babies: Morphology and mortuary implications of the Cro-Magnon immature remains

Partiot

Trinkaus

Knüsel

et al. 2020

Journal of Archaeological Science: Reports

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Although the adult skeletons discovered in 1868 at the Cro-Magnon site (Dordogne, France) have been studied several times, the immature remains known as Cro-Magnon 5 and exhumed at the same time were only analyzed in detail once, some thirty years ago. Since then, doubts have persisted concerning, in particular, the minimum number of immature individuals present in the assemblage. A re-analysis of these immature remains (cranial fragments and long bone diaphyses) documents the presence of three neonates and one older infant in the sample. They are morphologically and metrically similar to recent and Late Pleistocene modern human infants, although the metaphyses of one femur are modestly unusual. They also document an unusual mortuary age profile at Cro-Magnon, with four infants, three older adults, and an additional adult, which raises questions about the manner of selection of individuals deposited in the Cro-Magnon rock-shelter.

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Section: Mup Burial Age Distribution and Age Selection At Cro-magnonsupporting

confidence: 75%

Section: The Case Of the CM 4252-5 Femurmentioning

confidence: 99%

The Cro-Magnon babies: Morphology and mortuary implications of the Cro-Magnon immature remains

Partiot

Trinkaus

Knüsel

et al. 2020

Journal of Archaeological Science: Reports

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“…However, the extent to which there are (especially on CM 4327) discrete bony growths along the proximal femoral muscular attachments and along the midshaft linea aspera, combined with the large ossification of his left distal tibiofibular ligament, suggests that that Alpha suffered from more than age-related connective tissue ossifications. If these changes are combined with the CM 4325 distal femoral diaphyseal lesion, plus the changes elsewhere in the skeleton, it is evident that a systemic condition of genetic (Charlier et al, 2018), infectious (Dastugue, 1967), and/or idiopathic (Thillaud, 1981) origins was likely responsible for both the more pronounced lesions and a number of the minor changes.…”

Section: Paleopathologymentioning

confidence: 99%

Describing Cro-Magnon: The femora, tibiae and fibulae

Trinkaus

Sparacello

Xing

et al. 2022

Journal of Archaeological Science: Reports

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“…Towarzyszy ludzkooeci niemal od pocz¹tku jej istnienia, co równie¿ wskazuj¹ ostatnie doniesienia o endogennie uwarunkowanej niepe³nosprawnooeci u homo sapiens fossillisa z Cro-Magnon we Francji, ¿yj¹cego miêdzy 43 000-10 000 lat p.n.e. Antropolodzy wskazuj¹, i¿ cz³owiek kromanioñski choro-wa³ na genetycznie uwarunkowan¹ neurfibromatozê typu 1 (Charlier, i in. 2018).…”

Section: Niepe³nosprawnooeae Nabyta Weteranów Wojennychunclassified

Reedukacja weteranów z niepełnosprawnością nabytą - urazowym uszkodzeniem mózgu (TBI). Założenia teoretyczne i rozwiązania praktyczne

Borowska-Beszta¹

2019

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Reedukacja weteranów z niepe³nosprawnooeci¹ nabyt¹urazowym uszkodzeniem mózgu (TBI). Za³o¿enia teoretyczne i rozwi¹zania praktyczne Woeród autorów wspó³czesnych monografii i artyku³ów naukowych zagranicznych, zwi¹zanych z problematyk¹ wspierania niepe³nosprawnych ¿o³nierzy najwiêcej pooewiêca uwagê tematom kompleksowej rehabilitacji weteranów wojennych, z nabytymi niepe³nosprawnooeciami poznawczymi. Co ciekawe, w rehabilitacji weteranów g³ównie psycholodzy pisz¹ opracowania naukowe i wdra¿aj¹ praktycznie sposoby oddzia³ywania oparte na edukacji-kategorii pedagogicznej. Artyku³ precyzuje problematykê dotycz¹c¹ reedukacji weteranów z nabyt¹ niepe³nosprawno-oeci¹, na skutek urazowego uszkodzenia mózgu (TBI). Treoeci zosta³y podzielone na sekcje: definiowania i charakterystyki reedukacji, przegl¹du najczêoeciej notowanych w raportach naukowych form utraty zdrowia oraz obni¿enia funkcjonowania weteranów w wojnach XX i XXI wieku, m.in.: II wojnie oewiatowej, wojnie koreañskiej, wojnie w Wietnamie i w Zatoce Perskiej. Szczególna uwaga zosta³a pooewiêcona przybli¿eniu istoty urazowego uszkodzenia mózgu (TBI), jego skutków w funkcjonowaniu cz³owieka z dan¹ niepe³nosprawnooeci¹ a ponadto wskazaniu mo¿liwooeci nie tyle rehabilitacji-szeroko obecnej w opracowaniach naukowych, ile reedukacji podmiotowej, wspartej technologi¹ poprawiaj¹c¹ codzienne funkcjonowanie poznawcze, psychiczne i spo³eczne weteranów wojennych z TBI. S³owa kluczowe: nauki spo³eczne, reedukacja, edukacja, weterani, niepe³nosprawnooeae nabyta, urazowe uszkodzenie mózgu, TBI Reeducation of veterans with acquired disabilitytraumatic brain injury (TBI). A theoretical assumptions and practical solutions Among contemporary monographs and foreign scientific articles related to the issue of supporting disabled soldiers, the most attention is paid to the comprehensive rehabilitation of war veterans with acquired cognitive disabilities. Interestingly, in the rehabilitation of veterans, mainly psychologists write scientific studies and implement practically methods of support based on education-educational category. The greatest number of monographs and scientific articles is devoted to the complex cognitive rehabilitation of veterans with acquired cognitive disabilities. Interestingly, in rehabilitation psychologists use methods of interaction based on education. The article is a clarification of concepts related to the reeducation of veterans with acquired disabilities due to traumatic brain injury (TBI). The content has been divided into sections on defining re-education, reviewing the forms of health loss and veterans' functioning in World War II, the Korean War, the Vietnam War and the military conflict in Persian Gulf. Particular attention was devoted to the analysis and description of the traumatic brain injury and its effects in human functioning and reeducation supported by technology improving the everyday cognitive, psychological and social functioning of war veterans diagnosed as having TBI.

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Did Cro-Magnon 1 have neurofibromatosis type 1?

Cited by 10 publications

References 3 publications

The Cro-Magnon babies: Morphology and mortuary implications of the Cro-Magnon immature remains

The Cro-Magnon babies: Morphology and mortuary implications of the Cro-Magnon immature remains

Describing Cro-Magnon: The femora, tibiae and fibulae

Reedukacja weteranów z niepełnosprawnością nabytą - urazowym uszkodzeniem mózgu (TBI). Założenia teoretyczne i rozwiązania praktyczne

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