The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis

Haugland, Linn; Kristensen, Kasper Dahl; Lie, Stein Atle; Vandevska‐Radunovic, Vaska

doi:10.1093/ejo/cjy003

Cited by 18 publications

(13 citation statements)

References 58 publications

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“…Results of the current study demonstrated that MOP neither increased nor decreased root resorption, in contrast to a recent systematic review which accused corticotomy of increasing the orthodontically induced root resorption [31].…”

Section: Discussioncontrasting

confidence: 99%

Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial

et al. 2019

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Background Among the recent modalities introduced to accelerate orthodontic tooth movement (OTM) is micro-osteoperforations (MOPs), in other words, bone puncturing. The aim of this split-mouth trial was to investigate the effects of MOPs on the rate of OTM. Methods Eighteen patients requiring bilateral first premolar extraction and upper canine retraction with maximum anchorage were enrolled in this study. Immediately before canine retraction, three MOPs were randomly allocated to either the right or left sides. MOPs were performed using a mini-screw (1.8 mm diameter, 8 mm length) distal to the canine. Canine retraction continued for 4 months. Data were collected from monthly digital models, in addition to pre- and post-retraction maxillary CBCT images . The primary outcomes were the rate of canine retraction per month and the total distance moved by the canines. The secondary outcomes were the effect of MOPs on anchorage loss, canine root resorption, and pain. Results The mean rate of canine retraction in both sides was 0.99 ± 0.3 mm/month. The total distance moved by the canine cusp tip was greater in the MOP than the control side (mean difference 0.06 ± 0.7 mm), which was statistically insignificant ( P > 0.05(. The total distances moved by the canine center and apex were significantly greater in the MOP than the control side (mean difference 0.37 ± 0.63 mm ( P < 0.05) and 0.47 ± 0.56 mm ( P < 0.01) respectively). Insignificant differences were detected regarding anchorage loss and root resorption between both sides ( P > 0.05). Mild to moderate pain was experienced following the MOP procedure, which rapidly faded away within 1 week. Conclusions Micro-osteoperforations were not able to accelerate the rate of canine retraction; however, it seemed to facilitate root movement.

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Section: Discussioncontrasting

confidence: 99%

Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial

et al. 2019

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“…OIIRR is a common complication of orthodontic treatment, 22 which can be induced by the application of heavy orthodontic force, injury to moving teeth, metabolic diseases, traumatic occlusion, 23 and other causes (e.g., systemic conditions, 24 malocclusion type, 25 or treatment period 26 ). OIIRR is an inflammatory response characterized by the periodontal accumulation of many proinflammatory cytokines released from migrated cells and paradental resident cells, including TNF-α, interleukin-1β, interleukin-6, interleukin-7, interleukin-8, prostaglandin E2, and cyclooxygenase-2.…”

Section: Discussionmentioning

confidence: 99%

“…Several pharmacological agents (e.g., prostaglandin E2, zoledronate, alendronate, and fluoride) may prevent root resorption; however, the clinical applications of these agents are limited because they have adverse effects on orthodontic tooth movement. 2 – 4 Previous studies have shown that low-intensity pulsed ultrasound reduces the severity of OIIRR and promotes cementum repair by enhancing alkaline phosphatase activity, collagen-I synthesis, and runt-related transcription factor 2 (Runx-2) protein levels in cementoblasts. 5 , 6 However, extensive exposure to low-intensity pulsed ultrasound can cause occasional degeneration and fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats

et al. 2020

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Objective This study investigated the inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats. Methods Forty-five male Wistar rats were randomly divided into three groups of 15 rats each. Fifty grams of force was used to establish an orthodontic tooth movement model. Baicalin (40 mg/kg) was locally injected into rats in the baicalin group at 3-day intervals; concurrently, normal saline was injected into rats in the negative control group. On the 21st day after orthodontic treatment, the tooth movement distance and root resorption area ratio were measured. Histomorphology changes were observed by hematoxylin and eosin staining and immunohistochemistry. Results There was no significant difference in tooth movement distance between groups. The root resorption area ratio was significantly lower in the baicalin group than in the negative control group. Runx-2 expression was significantly higher in the baicalin group than in the negative control group, while tumor necrosis factor (TNF)-α expression was significantly lower in the baicalin group than in the negative control group. Conclusions Baicalin inhibits orthodontically induced inflammatory root resorption by enhancing the expression of Runx-2 and reducing the expression of TNF-α, but does not affect tooth movement distance.

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“…The authors of one Cochrane review 18 concluded that there was very little clinical research concerning the effectiveness of non‐surgical interventions on accelerating treatment during orthodontic treatment using fixed appliances. Hougland et al 19 evaluated the effect of biologic factors and adjunctive therapies on OIIRR; however, they included only those studies with fixed appliances. They assessed only 3 clinical studies on adjunctive interventions.…”

Section: Introductionmentioning

confidence: 99%

Impact of intraoral non‐pharmacological non‐surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: A systematic review

Al-Dboush

Flores-Mir

El‐Bialy

2021

Orthod Craniofacial Res

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Background The current systematic review aimed to assess the impact of intraoral non‐surgical non‐pharmacological adjunctive interventions on orthodontically induced inflammatory root resorption (OIIRR). Search methods Search without restrictions was performed up to November 2020 in three electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE) for randomized controlled trials (RCTs), prospective and retrospective non‐randomized studies. The ROB 2.0 tool was used to assess the quality of the included RCTs, and the ROBINS‐I tool was applied to non‐randomized clinical studies. The strength of evidence was ranked using GRADE. Results Three hundred and sixteen records were initially retrieved. A total of 10 studies, with 236 patients, were finally considered. These studies assessed the effects of mechanical vibration (low‐frequency and high‐frequency), low‐intensity pulsed ultrasound (LIPUS), low‐level laser therapy (LLLT) and photobiomodulation (light‐emitting devices (LED). While the low‐frequency vibration and LED do not seem to affect OIIRR, OIIRR has been reported to be reduced in high‐frequency vibration, and LIPUS‐treated teeth (differences may not likely be considered clinically relevant). The potential positive effect of LLLT on OIIRR is still debatable. Overall, the existing evidence suggests that the amount of OIIRR observed while using these interventions with traditional orthodontic treatment was not more than that was observed without it. Conclusions Based on a very low level of confidence, it seems that intraoral non‐pharmacological non‐surgical adjunctive interventions do not affect the amount of OIIRR either positively or negatively to a clinically relevant degree when compared to what is seen with conventional orthodontic treatment alone.

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The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis

Cited by 18 publications

References 58 publications

Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial

Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial

Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats

Impact of intraoral non‐pharmacological non‐surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: A systematic review

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