Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Binder, Alexandra M.; Corvalán, Camila; Calafat, Antònia M.; Ye, Xiaoyun; Mericq, Verónica; Pereira, Ana; Michels, Karin B.

doi:10.1186/s12940-018-0376-z

Cited by 68 publications

(58 citation statements)

References 71 publications

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“…Also, a study measuring the urinary concentration of triclosan in pregnant women has shown that for every doubling in concentration, the menarche of their daughters was one month earlier [15]. In addition, peripubertal exposure to triclosan is linked not only to earlier menarche, but also with earlier breast development in girls [8,16,17].…”

Section: Phenolsmentioning

confidence: 99%

“…It has been shown a correlation between the monoethyl phthalate (MEP) in pregnant women and an earlier onset of pubarche in their daughters [14]. Studying the effect of peripubertal exposure to MEP in overweight or obese girls, it has been demonstrated that this compound leads to earlier menarche [8,14].…”

Section: Phthalatesmentioning

confidence: 99%

“…The prevalence of precocious puberty is 1 in 5000 children and girls are 10 times more affected than boys [2]. An earlier onset of menarche has been associated with adverse health and social outcomes, such as shorter adult stature, an increased risk of type 2 diabetes, adult-onset asthma, cardiovascular disease and an increased risk of breast cancer and reproductive tract cancers [7][8][9][10]. Precocious puberty is also associated with many psychosocial disturbances, like an increased incidence of depression, withdrawal and internalizing disorders [2,11].…”

mentioning

confidence: 99%

“…The two main hypotheses for the actual tendency towards earlier menarche are: the increasing prevalence of childhood obesity and increasing environmental exposure to endocrine disruptor chemicals (EDCs) in household and personal care products [7,8,12].…”

mentioning

confidence: 99%

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Chemicals in Personal Care Products Tied to Early Puberty in Girls

Petca¹,

Boț²,

Petca³

et al. 2019

Rev. Chim.

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Precocious puberty is defined as the onset of menarche before 9 years of age, or the appearance of secondary sex characteristics before 8 years of age. It is associated with many psychosocial disturbances and adverse health outcomes such as: cardiovascular disease, shorter adult stature, an increased risk of type 2 diabetes and breast cancer. There is a general tendency to a progressive decrease in age of reaching puberty, specifically the onset of thelarche and menarche, girls being 10 times more affected than boys. This actual tendency can be explained by the increasing prevalence of childhood obesity and also by increasing environmental exposure to endocrine disruptor chemicals in household and personal care products.Phenols, phthalates, parabens and other compounds, such as polybrominated biphenyls and diethylstilbestrol are associated with precocious onset of puberty in girls, in case of in-utero or peripubertal exposure. These chemicals are frequently found in toothpaste, cosmetics, soups, shampoos, perfumes and other personal care products, interfering with sex hormones and puberty timing. This is why pregnant women should be more aware and avoid products based on these chemicals.

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Section: Phenolsmentioning

confidence: 99%

Section: Phthalatesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chemicals in Personal Care Products Tied to Early Puberty in Girls

Petca¹,

Boț²,

Petca³

et al. 2019

Rev. Chim.

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“…Oxybenzone (Benzophenone-3) has been linked to breast morphology alterations through weak binding of Estrogen receptor alpha and alteration of the expression of the progesterone receptor in mammary epithelium in mice [94]. An association with modulation effects on sexual maturation was also made in humans [95], where the substance was linked with earlier menarche. The substance has also been shown to be absorbed by dermal uptake [96].…”

Section: Uv Filtersmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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Menarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US

Wang,

Asokan,

Onnela

et al. 2024

JAMA Netw Open

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ImportanceEarly menarche is associated with adverse health outcomes. Trends toward earlier menarche have been observed in the US, but data remain limited on differences by sociodemographic factors and body mass index (BMI). Time from menarche to cycle regularity is another understudied early-life characteristic with health implications.ObjectivesTo evaluate the temporal trends and disparities in menarche and time to regularity and explore early-life BMI as a mediator.Design, Setting, and ParticipantsThis ongoing cohort study enrolled participants from an ongoing mobile application–based US cohort from November 14, 2019, to March 20, 2023.ExposuresBirth year (categorized as 1950-1969, 1970-1979, 1980-1989, 1990-1999, and 2000-2005).Main Outcomes and MeasuresMain outcomes were age at menarche and time to regularity, which were self-recalled at enrollment. In addition, early (aged &lt;11 years), very early (aged &lt;9 years), and late (aged ≥16 years) age at menarche was assessed.ResultsAmong the 71 341 female individuals who were analyzed (mean [SD] age at menarche, 12.2 [1.6] years; 2228 [3.1%] Asian, 3665 [5.1%] non-Hispanic Black, 4918 [6.9%] Hispanic, 49 518 [69.4%] non-Hispanic White, and 8461 [11.9%] other or multiple races or ethnicities), 5223 were born in 1950 to 1969, 12 226 in 1970 to 1979, 22 086 in 1980 to 1989, 23 894 in 1990 to 1999, and 7912 in 2000 to 2005. The mean (SD) age at menarche decreased from 12.5 (1.6) years in 1950 to 1969 to 11.9 (1.5) years in 2000 to 2005. The number of individuals experiencing early menarche increased from 449 (8.6%) to 1223 (15.5%), the number of individuals experiencing very early menarche increased from 31 (0.6%) to 110 (1.4%), and the number of individuals experiencing late menarche decreased from 286 (5.5%) to 137 (1.7%). For 61 932 participants with reported time to regularity, the number reaching regularity within 2 years decreased from 3463 (76.3%) to 4075 (56.0%), and the number not yet in regular cycles increased from 153 (3.4%) to 1375 (18.9%). The magnitude of the trend toward earlier menarche was greater among participants who self-identified as Asian, non-Hispanic Black, or other or multiple races (vs non-Hispanic White) (P = .003 for interaction) and among participants self-rated with low (vs high) socioeconomic status (P &lt; .001 for interaction). Within a subset of 9865 participants with data on BMI at menarche, exploratory mediation analysis estimated that 46% (95% CI, 35%-61%) of the temporal trend in age at menarche was explained by BMI.Conclusions and RelevanceIn this cohort study of 71 341 individuals in the US, as birth year increased, mean age at menarche decreased and time to regularity increased. The trends were stronger among racial and ethnic minority groups and individuals of low self-rated socioeconomic status. These trends may contribute to the increase in adverse health outcomes and disparities in the US.

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Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Cited by 68 publications

References 71 publications

Chemicals in Personal Care Products Tied to Early Puberty in Girls

Chemicals in Personal Care Products Tied to Early Puberty in Girls

Endocrine Disruption by Mixtures in Topical Consumer Products

Menarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US

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