How to predict and improve prognosis of food allergy

Dahdah, Lamia; Pecora, Valentina; Riccardi, Carla; Fierro, Vincenzo; Valluzzi, Rocco Luigi; Mennini, Maurizio

doi:10.1097/aci.0000000000000446

Cited by 5 publications

(9 citation statements)

References 33 publications

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“…[19][20][21] Identification of clinical factors that accurately predict the prognosis of food allergy may help clarify the involved mechanisms. 22 We performed a systematic review of studies of the natural history of food allergy, focusing on predictive factors for outgrowing an allergy. We used "food allergy" and "natural history" as keywords to conduct a PubMed search of original research articles in English, published from January 1963 through April 2020.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

Hamada

Nagao

Imakiire

et al. 2021

Pediatric Allergy Immunology

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Background: Safely liberalizing the diet to include an allergenic food may accelerate resolution of food allergy. The outcome of liberalization, however, varies among patients. Methods:We conducted a prospective observational study to identify factors associated with outcome for egg allergy 1 year after oral food challenge (OFC). We enrolled children <72 months old who had egg allergy and underwent OFC for determination of the safe intake quantity of egg allergen. Each child's baseline clinical background was recorded. Caregivers used the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) to assess their children's QoL. Dietary advice based on the OFC result was provided to support safe egg consumption. At 1 year after OFC, the quantity of egg each child safely consumed in daily life was surveyed. We classified the outcome as Successful (Group S) if the quantity increased during the 1 year, or as Unsuccessful (Group U) if it did not. Factors associated with the outcome were investigated by multivariate logistic regression analysis.Results: A total of 93 children were enrolled, and after 1 year, 57 finished in Group S and 36 in Group U. The mean FAQLQ-PF score at baseline was significantly lower (ie, a better QoL) in Group S than in Group U. Multivariate logistic regression analysis identified a good QoL and absence of comorbid asthma or atopic dermatitis as factors predicting a favorable outcome. Conclusion:QoL may affect food allergy outcome. Intervention focusing on the QoL may promote outgrowing of food allergies.

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Section: Discussionmentioning

confidence: 99%

Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

Hamada

Nagao

Imakiire

et al. 2021

Pediatric Allergy Immunology

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show abstract

“…The analysis of IgE levels in different age groups (0-2 years, 2-6 years, and over 6 years) showed that total IgE levels are lower in older children compared to those in young patients. Sichereret et al described in their study that food allergies, defined as an immune response to food proteins, affect about 8% of children and 2% of adults [5], but the prevalence is increasing, as is the case with all allergic diseases. In the case of food allergies, the mechanisms involved may be IgE-mediated or non-IgE-mediated immunological reactions.…”

Section: Discussionmentioning

confidence: 99%

“…Sichereret et al described in their study that food allergies, defined as an immune response to food proteins, affect about 8% of children and 2% of adults [ 5 ], but the prevalence is increasing, as is the case with all allergic diseases. In the case of food allergies, the mechanisms involved may be IgE-mediated or non-IgE-mediated immunological reactions.…”

Section: Discussionmentioning

confidence: 99%

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The Importance of Diet in Predicting the Remission of Urticaria—Determination of Allergen-Specific IgE

et al. 2021

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Background and Objectives: Different types of food introduced gradually in the diet will expose children to different food allergens, increasing the chance of developing allergic diseases. The aim of our study was to determine if allergen-specific IgE values can influence, depending on the diet, the prediction of remission of urticaria in children. Materials and Methods: This prospective study was conducted in 132 patients diagnosed over two years with urticaria, admitted to “Sf. Maria” Clinical Pediatric Hospital Iaşi. Total IgE assay was performed by ELISA, and determination of specific serum IgE by the CLA System Quanti Scan method (Innogenetics, Heiden, Germany). Data were gathered and statistical analysis was performed using statistical software SPSS, using descriptive and inferential statistics. Results: The determination of specific IgE to food allergens was performed on a total of 132 cases. The values of specific IgE were positive for one or more food allergens in 84 patients (63.64%). The most common allergens involved were: cow’s milk in 33.3% cases, egg white in 22.6% cases, and hazelnuts in 11.9% cases. The specific IgE values for the different types of food included in our study had a predictive value for disease remission. Conclusions: The determination of specific IgE confirms the presence of a particular food allergen and may have predictive value for the future development of an allergic manifestation.

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“…[21][22][23] Identification of clinical factors that accurately predict the prognosis of food allergy may help delineate the involved mechanisms. 24 We performed a systematic review of studies of the natural history of food allergy, focusing on predictive factors for outgrowing an allergy. We used "food allergy" AND "natural history" as keywords to conduct a Pubmed search of original research articles in English, published from January 1963 through April 2020.…”

Section: Discussionmentioning

confidence: 99%

A good QoL is beneficial for outgrowing egg allergy

Hamada¹,

Nagao²,

Imakiire³

et al. 2020

Preprint

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Background: Safely liberalizing the diet to include an allergenic food may accelerate resolution of food allergy. The outcome of liberalization, however, varies among patients. Methods: We conducted a prospective observational study to identify factors associated with outcome for egg allergy 1 year after oral food challenge (OFC). We enrolled children < 72 months-old who had egg allergy and underwent OFC for determination of the safe intake quantity of egg allergen. At enrollment, each child’s clinical background was recorded. The Food Allergy Quality of Life Questionnaire–Parent Form (FAQLQ–PF) was administered to the caregivers to assess their children’s QoL. Dietary advice based on the OFC result was then provided to support safe consumption of eggs. At 1 year after OFC, the quantity of egg each child safely consumed in daily life was surveyed. We classified the egg allergy outcome as Outgrowing (Group O) if the quantity increased during the 1 year, or as Non-outgrowing (Group N) if it did not. Factors associated with the outcome were investigated by multivariate logistic regression analysis. Results: A total of 93 children were enrolled, and after 1 year 57 finished in Group O and 36 in Group N. The mean FAQLQ-PF score at baseline was significantly lower (i.e., better QoL) in group O than in group N. Multivariate logistic regression analysis identified comorbid asthma, comorbid atopic dermatitis and a poor QoL as factors predicting an unfavorable outcome. Conclusion: QoL may affect food allergy outcome. Intervention focusing on QoL may promote outgrowing food allergies.

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How to predict and improve prognosis of food allergy

Cited by 5 publications

References 33 publications

Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

The Importance of Diet in Predicting the Remission of Urticaria—Determination of Allergen-Specific IgE

A good QoL is beneficial for outgrowing egg allergy

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