Antibacterial secotirucallane triterpenes from the stem bark of <i>Pseudocedrela kotschyi</i>

Mambou, Christèle Sorèle; Nono, Raymond Ngansop; Chouna, Jean Rodolphe; Tamokou, Jean-De-Dieu; Nkeng-Efouet-Alango, Pépin; Sewald, Norbert

doi:10.1515/znc-2017-0207

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…These include, 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid ( 28 ), 3,4-secotirucalla-4(29),7,24-trien-3,21-dioic acid ( 29 ) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic ( 30 ) ( Figure 4 ) (Mambou et al. 2018 ). Two flavonoids, namely, 3,6,8-trihydroxy-2-(3,4-dihydroxylphenyl)-4H-chrom-4-one ( 31 ) and quercetin, 3,4′,7-trimethyl ether ( 32 ) ( Figure 4 ) have also been isolated from the roots of this plant (Sidjui et al.…”

Section: Methodsmentioning

confidence: 99%

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Pseudocedrela kotschyi : a review of ethnomedicinal uses, pharmacology and phytochemistry

Alhassan

Ahmed

Malami

et al. 2021

Pharmaceutical Biology

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Context: Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) is an important medicinal plant found in tropical and subtropical countries of Africa. Traditionally, P. kotschyi is used in the treatment of various diseases including diabetes, malaria, abdominal pain and diarrhoea. Objective: To provide an overview of traditional medicinal claims, pharmacological properties, and phytochemical principles of P. kotschyi as a basis for its clinical applications and further research and development of new drugs. Methods: Through interpreting already published scientific manuscripts retrieved from different scientific search engines, namely, Medline, PubMed, EMBASE, Science Direct and Google scholar databases, an upto-date review on the medicinal potentials of P. kotschyi from inception until September, 2020 was compiled. 'Pseudocedrela kotschyi', 'traditional uses', 'pharmacological properties' and 'chemical constituents' were used as search words. Results: At present, more than 30 chemical constituents have been isolated and identified from the root and stem bark of P. kotschyi, among which limonoids and triterpenes are the main active constituents. Based on prior research, P. kotschyi has been reported to possess anti-inflammatory, analgesic, antipyretic, anthelminthic, antimalaria, anti-leishmaniasis, anti-trypanosomiasis, hepatoprotective, antioxidant, antidiabetic, antidiarrheal, antimicrobial, and anticancer effects. Conclusions: P. kotschyi is reported to be effective in treating a variety of diseases. Current phytochemical and pharmacological studies mainly focus on antimalaria, anti-leishmaniasis, anti-trypanosomiasis and anticancer potential of the root and stem bark of P. kotschyi. Although experimental data support the beneficial medicinal properties of this plant, there is still a paucity of information on its toxicity profile. Nonetheless, this review provides the basis for future research work.

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Section: Methodsmentioning

confidence: 99%

“…Compound 29 exhibited the highest antibacterial activity while 30 had the lowest (Mambou et al. 2018 ). The presence of these compounds is likely responsible for the antimicrobial property of P. kotschyi extracts and justify the ethnomedicinal use of this plant as a chewing stick for tooth cleaning and enhancement of oral health.…”

Section: Methodsmentioning

confidence: 99%

Pseudocedrela kotschyi : a review of ethnomedicinal uses, pharmacology and phytochemistry

Alhassan

Ahmed

Malami

et al. 2021

Pharmaceutical Biology

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“…Some of these isolates are reported to possess antimalarial [ 18 ], anti-inflammatory, antitumor [ 16 , 19 ], antimicrobial [ 13 , 15 ], analgesic [ 4 , 20 ], antianaphylactic [ 4 , 21 ], and antioxidant activities [ 4 , 14 , 16 , 19 ]. As part of our ongoing search for bioactive compounds from Cameroonian medicinal plants [ 22 , 23 , 24 ], we report thirteen secondary metabolites, including two new limonoids ( 1 , 2 ) obtained from the ethanol extract of T. monadelpha stem bark, which we have assessed for their antibacterial and antiplasmodial activities against known pathogenic strains.…”

Section: Introductionmentioning

confidence: 99%

Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

et al. 2023

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The chemical investigation of the EtOH extract from the stem bark of Trichilia monadelpha (Thonn.) J. J. De Wilde afforded two new limonoids (1 and 2): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (1) and (6R)-1-O-deacetylkhayanolide E (2), together with eleven known compounds (3–13), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including Staphylococcus aureus and Plasmodium falciparum. Fraction E (n-Hex/EtOAc 30:70, v/v) showed significant activity against S. aureus ATCC 25923 with a MIC value of 3.90 µg/mL, while one of its constituents (epicatechin (9)) exhibited significant activity with MIC values of 7.80 µg/mL. Interestingly, grandifotane A (6) (IC50 = 1.37 µM) and khayanolide D (5) (IC50 = 1.68 µM) were highly active against the chloroquine-sensitive/sulfadoxine-resistant plasmodium falciparum 3D7 strain, unlike their corresponding plant extract and fractions.

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“…The 5-valved dehiscent capsule contains many seeds. People in sub-Saharan regions use it to cure several diseases (Kpodar et al, 2016;Elufioye et al, 2017;Mambou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Study of the analgesic activity of the aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) trunk bark

2022

Int. J. Biosci.

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Pseudocedrela kotschyi is a traditional medicine plant used by people in sub-Saharan regions to cure several diseases. The main objective of this study is to evaluate the analgesic activity of the aqueous extract of Pseudocedrela kotschyi trunk bark. Phytochemical screening revealed the presence of alkaloids, flavonoids, catechic tannins, saponosides, polyphenols, quinones, terpenoids, oses and holosides whereas coumarins and gallic tannins are absent. In the acute toxicity study, oral administration of the aqueous extract of Pseudocedrela kotschyi trunk bark did not cause any death among the rats. According to the organisation for economic cooperation and development (OECD) 423 classification system (OECD, 2001), the lethal dose 50 (LD50) of such an extract is therefore greater than 5000mg/kg body weight. On the other hand, this aqueous extract administered intraperitoneally provoked the death of certain mice. Thus an LD50 of 230.08mg/kg body weight was calculated. According to the classification of Diezi (1989), the aqueous extract of the trunk bark of this Pseudocedrela kotschyi is toxic by the intraperitoneal administration. Evaluation of the analgesic activity shows that the aqueous extract of this plant induces a decrease in the number of abdominal cramps in the writhing test and an inhibition of pain in the second phase of the formaldehyde test. On the other hand, the extract has no inhibiting effect on pain in the tail flick test and in the first phase of the formaldehyde test. These results justify the traditional use of Pseudocedrela kotschyi bark against pain.

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Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi

Cited by 8 publications

References 18 publications

Pseudocedrela kotschyi : a review of ethnomedicinal uses, pharmacology and phytochemistry

Pseudocedrela kotschyi : a review of ethnomedicinal uses, pharmacology and phytochemistry

Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

Study of the analgesic activity of the aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) trunk bark

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