Effect of Eicosapentaenoic acid (EPA) supplementation on cardiovascular markers in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Golzari, Mohammad Hassan; Javanbakht, Mohammad Hassan; Ghaedi, Ehsan; Mohammadi, Hamed; Djalali, Mahmoud

doi:10.1016/j.dsx.2018.03.003

Cited by 19 publications

(11 citation statements)

References 34 publications

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“…AIP and associated risk factors may be improved through management. Measures found to be effective include dietary modifications [53], aerobic exercise [54], and supplementation with EPA [55]. This study added to the store of accumulated knowledge by identifying AIP as a clinically convenient index for detection and positing an association between AIP and risk factors for CVD and cerebrovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications

Huang

Sun

et al. 2018

International Journal of Endocrinology

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Objective This study was designed to investigate risk factors related to atherogenic index of plasma (AIP), as well as the relationship between AIP and chronic microvascular complications in patients with type 2 diabetes (T2DM). Methods This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018. Anthropometric indicators were measured after overnight fasting. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) were detected by enzymatic analysis. Standard 75 g oral glucose tolerance testing was performed to measure 0 and 2 hr plasma levels of glucose and insulin. Insulin sensitivity was assessed with HOMA-IR. Results Increase in AIP was associated with an increased risk for hypertension (P < 0.05), HbA1c (P < 0.05), HOMA-IR (P < 0.05), UA (P < 0.05), and decreased eGFR levels (P < 0.05). Furthermore, AIP values directly correlated with BMI (r = 0.182, P < 0.001), waist circumference (r = 0.129, P < 0.001), blood glucose index (FBG (r = 0.153, P < 0.001), PPBG (r = 0.117, P < 0.001), and HbA1c (r = 0.074, P < 0.001)), insulin resistance (HOMA-IR; r = 0.112, P < 0.001), and uric acid (UA, r = 0.177, P < 0.001). Multiple logistic regression analysis showed that waist circumference, HOMA-IR, FBG, systolic blood pressure, and UA were independent risk factors for AIP (all P < 0.05). The prevalence of diabetic neuropathy and metabolic syndrome was significantly higher among patients with higher AIP. Conclusion AIP represents a clinically convenient indicator for the detection of T2DM with high risk of complications and associated diseases and thus is a good predictor and indicator for follow-up monitoring in the treatment of patients with high-risk type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications

Huang

Sun

et al. 2018

International Journal of Endocrinology

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“…Health claims which emphasized that omega-3 have cardioprotective effect are clinically approved and in accordance with scientific evidence. 22,25 FDA stated positions in response to certain ''qualified health claim'' petitions regarding consumption of EPA and DHA omega-3 fatty acids and a reduced risk of coronary heart disease. ''Based on FDA's consideration of the scientific evidence and other information submitted with your petition, and other pertinent scientific evidence and information, FDA concludes that there is sufficient evidence for a qualified health claim, provided that the qualified claim is appropriately worded so as to not mislead consumers.…”

Section: Discussionmentioning

confidence: 99%

Internet Marketing of Cardioprotective Dietary Supplements

Bjelica

Aleksić

Goločorbin-Kon

et al. 2020

The Journal of Alternative and Complementary Medicine

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Objectives: Considering high prevalence of use of dietary supplements and their easy access on the internet, the aim of this research was to examine and assess the prevalence of the internet marketing of heart-protective supplements as the most popular supplements of today, and to investigate the quality and quantity of information that are available to consumers on the sale websites. Design: Three major search engines (Google, Yahoo, and Bing) and keywords ''cardiovascular supportive supplements online buy'' were used to identify websites that sell cardioprotective dietary supplements. Content of first 50 listed websites in each engine was evaluated for its compliance with regulatory acts while information about supplements' efficacy and safety was compared with the results of the latest scientific research. Results: Of a total of 150 listed websites, 89 selling supplements for the specific indication underwent further analysis. The most commonly registered cardioprotective dietary supplements on the internet were supplements based on omega-3 fatty acids (omega-3) (57 websites, 64.05%). Related to the websites selling omega-3 supplements, risk reduction claims were presented at 23 (40.35%), whereas structure or function claims were present at 50 (87.72%) analyzed websites, but followed with Food and Drug Administration disclaimer only on 68.00% of them. Information about adverse effects were rarely pointed out (1 website, 1.75%) unlike warnings, which were significantly more available to consumers (38, 66.67%). Conclusions: According to obtained results, most of the analyzed websites that sell omega-3 supplements did not contain all important medical information required by Dietary Supplement Health and Education Act. Since use of internet marketing is in expansion and since consumers have no access to relevant medical information about dietary supplements on the selling websites, there is a clear need for better quality control of websites and greater public awareness of these widely used products.

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“…However, routine lipid measures may not fully re ect the compositional changes of lipid metabolism in patients with diabetes. AIP, as a comprehensive index of dyslipidemia in diabetic patients may be improved through managements, such as dietary modi cations [35], aerobic exercise [36] and supplementation with eicosapentaenoic acid [37]. Therefore, AIP may be a potential therapeutic target and a clinically convenient index for monitoring patients during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of atherogenic index of plasma in patients with type 2 diabetes and acute coronary syndrome

Wang¹,

Cong²,

Zhang³

et al. 2020

Preprint

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Background: Atherogenic index of plasm (AIP) has been identified as a risk factor for cardiovascular disease (CVD) and an independent predictor of mortality. However, it remains unknown whether AIP level may predict mortality in patients with diabetes and acute coronary syndrome (ACS). Methods: A total of 2531 consecutive patients with type 2 diabetes who underwent coronary angiography for ACS were enrolled in the study. Patients were divided into tertiles according to admission AIP level. The AIP was calculated as the base 10 logarithm of the ratio of the fating concentration of triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C). The primary endpoints were all-cause death and cardiovascular death. Multivariate cox hazard regression analysis were performed to calculate the hazard ratio(HR)and 95％confidence interval(CI)．C-statistics, continuous net reclassification improvement(NRI)，and integrated discrimination improvement(IDI) were calculated to evaluate the added prognostic value of AIP beyond the established mode for prediction of death．Results: During 3-year follow-up, all-cause death events occurred in 142 cases and cardiovascular death events occurred in 120 cases, respectively. The risk of all-cause death and cardiovascular death increased with AIP tertiles at a 3-year follow-up. The Kaplan-Meier curves showed that significant differences in event-free survival rates among AIP tertiles(all-cause mortality: p=0.006; cardiovascular mortality: p=0.003).Multivariate cox hazard regression analysis revealed that AIP was independently associated with all-cause death (HR: 3.859, 95% CI:1.926-7.734; p<0.001) and cardiovascular death (HR:4.723, 95% CI: 2.243-9.946; p<0.001). Addition of AIP to the established mode for mortality prediction was not associated with a significant improvement in the C-statistics value but there were significant improvements in reclassification for all-cause death (NRI: 0.198, p=0.022; IDI: 0.008, p=0.016) and cardiovascular death (NRI: 0.260, p=0.006; IDI: 0.010, p=0.021).Conclusions: Admission AIP was independently correlated with long-term mortality in patients with type 2 diabetes and ACS. These findings suggest that AIP may optimize the mortality prediction among patients with diabetes and ACS.

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Effect of Eicosapentaenoic acid (EPA) supplementation on cardiovascular markers in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Cited by 19 publications

References 34 publications

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications

Internet Marketing of Cardioprotective Dietary Supplements

Prognostic value of atherogenic index of plasma in patients with type 2 diabetes and acute coronary syndrome

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