CEP peptide hormones: key players in orchestrating nitrogen-demand signalling, root nodulation, and lateral root development

Taleski, Michael; Imin, Nijat; Djordjevic, Michael A.

doi:10.1093/jxb/ery037

Cited by 79 publications

(48 citation statements)

References 69 publications

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“…Besides the classical phytohormones discussed so far, small, secreted peptide hormones are also potent modulators of plant growth and development. It has become increasingly evident that secreted peptides play critical roles in mediating a range of plant-microbe interactions, either by induction of PPH gene expression, for instance during legume-rhizobium symbioses, or by secreting PPH effector mimics (Yamaguchi et al, 2016;Ronald and Joe, 2018;Taleski et al, 2018). Here, we focus on PPH effector mimics secreted by nematodes, the first animal-pathogen model identified to secrete such molecules for parasitism.…”

Section: Nematodes Secrete Pph Effector Mimics For Feeding Site Formamentioning

confidence: 99%

Phytoparasitic Nematode Control of Plant Hormone Pathways

2018

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Section: Nematodes Secrete Pph Effector Mimics For Feeding Site Formamentioning

confidence: 99%

Phytoparasitic Nematode Control of Plant Hormone Pathways

2018

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“…In legumes, CEPs regulate nodulation and lateral root development (Taleski et al . ) through the CEP receptor CRA2 (COMPACT ROOT ARCHITECHTURE 2) that is most similar to Arabidopsis CEPR1 (Imin et al . ; Mohd‐Radzman et al .…”

Section: Post‐translationally Modified Peptides and Peptide Familiesmentioning

confidence: 99%

“…The signals that are sent from the shoot to the root are two phloem-mobile polypeptides called CEP DOWNSTREAM (CEPD1) and CEPD2 that are responsible for CEPR1-dependent induction of the nitrate transporter NRT2.1 (Ohkubo et al 2017). In legumes, CEPs regulate nodulation and lateral root development (Taleski et al 2018) through the CEP receptor CRA2 (COMPACT ROOT ARCHITECHTURE 2) that is most similar to Arabidopsis CEPR1 Mohd-Radzman et al 2016). Mohd-Radzman et al (2016) demonstrated that CEP1 from Medicago truncatula promotes nodulation via the CRA2 receptor in an ethylene-dependent manner, whereas inhibition of lateral root development through CRA2 is independent from ethylene.…”

Section: C-terminally Encoded Peptides (Ceps)mentioning

confidence: 99%

“…CEP peptides isolated from Medicago root exudates were found to possess staggered N-and C-terminal extensions, suggesting an endoproteolytic cleavage event as pre-activation step, followed by the trimming of N-and C-termini by exo-peptidases. Any extension at the N-or C-terminus impaired CEP activity, highlighting the importance of exo-peptidase-mediated trimming for peptide maturation Taleski et al 2018).…”

Section: Proteolytic Processing: N-terminal Maturationmentioning

confidence: 99%

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Regulation of plant peptide hormones and growth factors by post‐translational modification

Stührwohldt

Schaller

2018

Plant Biol J

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The number, diversity and significance of peptides as regulators of cellular differentiation, growth, development and defence of plants has long been underestimated. Peptides have now emerged as an important class of signals for cell-to-cell communication over short distances, and also for long-range signalling. We refer to these signalling molecules as peptide growth factors and peptide hormones, respectively. As compared to remarkable progress with respect to the mechanisms of peptide perception and signal transduction, the biogenesis of signalling peptides is still in its infancy. This review focuses on the biogenesis and activity of small post-translationally modified peptides. These peptides are derived from inactive pre-pro-peptides of approximately 70-120 amino acids. Multiple post-translational modifications (PTMs) may be required for peptide maturation and activation, including proteolytic processing, tyrosine sulfation, proline hydroxylation and hydroxyproline glycosylation. While many of the enzymes responsible for these modifications have been identified, their impact on peptide activity and signalling is not fully understood. These PTMs may or may not be required for bioactivity, they may inactivate the peptide or modify its signalling specificity, they may affect peptide stability or targeting, or its binding affinity with the receptor. In the present review, we will first introduce the peptides that undergo PTMs and for which these PTMs were shown to be functionally relevant. We will then discuss the different types of PTMs and the impact they have on peptide activity and plant growth and development. We conclude with an outlook on the open questions that need to be addressed in future research.

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“…Two EPIDERMAL PATTERNING FACTOR‐LIKE (EPFL) secreted peptides, EPFL4 and EPFL6, interact with the ERECTA receptor kinase to coordinate proper inflorescence development in Arabidopsis (Uchida et al ). The C‐terminally encoded peptide (CEP) and CEP receptor (CEPR) complex are involved in regulating root development and systemic nitrogen‐demand signaling in plants (Tabata et al ; Taleski et al ; Yu et al ). Since STMPs are novel secreted peptides, they likely also require specific receptor(s).…”

Section: Discussionmentioning

confidence: 99%

The Brassicaceae‐specific secreted peptides, STMPs, function in plant growth and pathogen defense

Zhu

et al. 2019

JIPB

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Low molecular weight secreted peptides have recently been shown to affect multiple aspects of plant growth, development, and defense responses. Here, we performed stepwise BLAST filtering to identify unannotated peptides from the Arabidopsis thaliana protein database and uncovered a novel secreted peptide family, secreted transmembrane peptides (STMPs). These low molecular weight peptides, which consist of an N‐terminal signal peptide and a transmembrane domain, were primarily localized to extracellular compartments but were also detected in the endomembrane system of the secretory pathway, including the endoplasmic reticulum and Golgi. Comprehensive bioinformatics analysis identified 10 STMP family members that are specific to the Brassicaceae family. Brassicaceae plants showed dramatically inhibited root growth upon exposure to chemically synthesized STMP1 and STMP2. Arabidopsis overexpressing STMP1, 2, 4, 6, or 10 exhibited severely arrested growth, suggesting that STMPs are involved in regulating plant growth and development. In addition, in vitro bioassays demonstrated that STMP1, STMP2, and STMP10 have antibacterial effects against Pseudomonas syringae pv. tomato DC3000, Ralstonia solanacearum, Bacillus subtilis, and Agrobacterium tumefaciens, demonstrating that STMPs are antimicrobial peptides. These findings suggest that STMP family members play important roles in various developmental events and pathogen defense responses in Brassicaceae plants.

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CEP peptide hormones: key players in orchestrating nitrogen-demand signalling, root nodulation, and lateral root development

Cited by 79 publications

References 69 publications

Phytoparasitic Nematode Control of Plant Hormone Pathways

Phytoparasitic Nematode Control of Plant Hormone Pathways

Regulation of plant peptide hormones and growth factors by post‐translational modification

The Brassicaceae‐specific secreted peptides, STMPs, function in plant growth and pathogen defense

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