Imaging findings of hereditary renal tumors, a review of what the radiologist should know

Czarniecki, Marcin; Gautam, Rabindra; Choyke, Peter L.; Türkbey, Barış

doi:10.1016/j.ejrad.2018.01.026

Cited by 12 publications

(8 citation statements)

References 54 publications

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“…The presence of a solid fatty renal lesion, eg, angiomyolipoma, can point toward tuberous sclerosis; this diagnosis is supported by characteristic dermatologic findings, chest computed tomography (CT) with lymphangioleiomyomatosis, and brain MRI to identify subependymal tubers . A diagnosis of VHL disease is suggested by retinal and central nervous system hemangioblastomas, endolymphatic sac tumors, renal cysts, renal cell carcinoma (RCC; clear cell type), pancreatic cysts and tumors, pheochromocytoma, and epididymal cystadenomas . Gene testing, together with genetic counseling and imaging, are often required to confirm the diagnosis of cystic kidney diseases …”

Section: Mri For the Diagnosis Of Adpkdmentioning

confidence: 99%

“…A diagnosis of VHL disease is suggested by retinal and central nervous system hemangioblastomas, endolymphatic sac tumors, renal cysts, renal cell carcinoma (RCC; clear cell type), pancreatic cysts and tumors, pheochromocytoma, and epididymal cystadenomas . Gene testing, together with genetic counseling and imaging, are often required to confirm the diagnosis of cystic kidney diseases …”

Section: Mri For the Diagnosis Of Adpkdmentioning

confidence: 99%

“…27 A diagnosis of VHL disease is suggested by retinal and central nervous system hemangioblastomas, endolymphatic sac tumors, renal cysts, renal cell carcinoma (RCC; clear cell type), pancreatic cysts and tumors, pheochromocytoma, and epididymal cystadenomas. 28,29 Gene testing, together with genetic counseling and imaging, are often required to confirm the diagnosis of cystic kidney diseases. 28,29 Cystic renal enlargement must be differentiated from hydronephrosis, which in our experience with an ADPKD data registry involving >300 subjects, is mistaken for ADPKD in~1% of cases, especially by ultrasonography.…”

Section: Value Of Mri In the Diagnosis Of Adpkd Without A Family Historymentioning

confidence: 99%

“…28,29 Gene testing, together with genetic counseling and imaging, are often required to confirm the diagnosis of cystic kidney diseases. 28,29 Cystic renal enlargement must be differentiated from hydronephrosis, which in our experience with an ADPKD data registry involving >300 subjects, is mistaken for ADPKD in~1% of cases, especially by ultrasonography. However, hydronephrosis is more easily differentiated from ADPKD on MRI.…”

Section: Value Of Mri In the Diagnosis Of Adpkd Without A Family Historymentioning

confidence: 99%

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MRI in autosomal dominant polycystic kidney disease

Zhang

Blumenfeld

Prince

2019

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is increasingly used in autosomal dominant polycystic kidney disease (ADPKD) for diagnosis, classification, assessment of disease progression and treatment response, and for identifying complications. Herein we review the role of MRI in the management of patients with ADPKD. We show how MRI‐derived total kidney volume is a biomarker for assessing ADPKD severity and predicting decline in renal function. We also demonstrate the MR appearances of common complications. Level of Evidence: 3 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:41–51.

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Section: Mri For the Diagnosis Of Adpkdmentioning

confidence: 99%

Section: Mri For the Diagnosis Of Adpkdmentioning

confidence: 99%

Section: Value Of Mri In the Diagnosis Of Adpkd Without A Family Historymentioning

confidence: 99%

Section: Value Of Mri In the Diagnosis Of Adpkd Without A Family Historymentioning

confidence: 99%

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MRI in autosomal dominant polycystic kidney disease

Zhang

Blumenfeld

Prince

2019

Magnetic Resonance Imaging

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“…Both RCC and UC are more common in men vs. women. RCC originates from proximal convoluted tubule including clear cell renal carcinoma, papillary RCC, chromophobe RCC, collecting duct RCC, renal medullary carcinoma and sarcomatoid RCC (6). While UC arises from the transitional epithelium, including papillary and non-papillary transitional cell carcinomas.…”

Section: Introductionmentioning

confidence: 99%

Intrarenal urothelial cancers confused as infiltrative renal masses: Report of 22�cases and literature review

Ding

Jia

et al. 2018

Oncol Lett

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Distinguishing infiltrative renal masses (IRMs) from intrarenal urothelial cancers (IUCs) is critically important, but may be challenging for any radiologist or urologist. The present study aimed to summarize the clinical, imaging and pathological characteristics of IRM, which were postoperatively confirmed as IUC. The analysis was performed using the records of 22 patients who were preoperatively diagnosed with IRM but the results of percutaneous biopsies or postoperative pathological analyses led to diagnoses of urothelial cancers (UCs) from January 2011 to December 2017. The demographic data, computed tomography (CT) imaging features and pathological characteristics were evaluated. The present study also reviewed the literature concerning the IRM and IUC. The mean age of patients was 62 years and 86.4% of them were >55 years. The sex and tumor side distributions were equal. Hematuria and/or flank pain were observed in 86.4% of patients. All patients exhibited endophytic solid renal masses with unclear tumor boundaries on CT images. The kidneys of 81.8% of patients maintained their normal shape while mild alternations were observed in 18.2% of cases. A total of 81.8% of patients maintained the reniform shape and 18.2% exhibited mild contour change. Of all patients, all tumors exhibited less or equal attenuation on unenhanced CT images and they were mildlyimproved on enhanced CT. A total of 6 cases were confirmed by biopsy, when patients underwent laparoscopic nephroureterectomy instead of radical nephrectomy. The remaining 16 patients underwent laparoscopic nephrectomy but the postoperative pathological diagnoses revealed the presence of UCs. All postoperatively confirmed cancers were stages T3 and T4 (62.5 and 37.5%, respectively). UCs should be suspected in middle aged or elderly middle-elderly patients presenting renal masses with endophytic solid unclear tumor boundary on unenhanced and slightly enhanced CT images, accompanied with hematuria and/or flank pain. Preoperative biopsy is preferred for complicated cases.

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