Paediatric Intestinal Pseudo‐obstruction

Thapar, Nikhil; Saliakellis, Efstratios; Benninga, Marc A.; Borrelli, Osvaldo; Curry, Joe; Fauré, Christophe; Giorgio, Roberto De; Gupte, Girish; Knowles, Charles H.; Staiano, Annamaria; Vandenplas, Yvan; Lorenzo, Carlo Di

doi:10.1097/mpg.0000000000001982

Cited by 113 publications

(258 citation statements)

References 286 publications

Supporting

Mentioning

224

Contrasting

Unclassified

Order By: Relevance

“…Pediatric intestinal pseudo-obstruction is a rare and debilitating group of intestinal motility disorders, which manifests as chronic symptoms of obstruction in the absence of a true mechanical obstruction. 1 Until recently, this group of disorders was classified as "chronic intestinal pseudo-obstruction," an entity that encompassed both adult and pediatric populations. Recent research has highlighted pediatric intestinal pseudo-obstruction as a separate entity specific to the pediatric population.…”

Section: Introductionmentioning

confidence: 99%

“…Recent research has highlighted pediatric intestinal pseudo-obstruction as a separate entity specific to the pediatric population. 1 Symptoms are nonspecific, but may include recurrent episodes of intestinal pseudo-obstruction, pain, urologic involvement, intestinal malrotation, or intestinal volvulus. The definition of symptom chronicity is dependent on age of presentation; at least 2 months is required if symptoms are evident at birth and at least 6 months if symptoms develop after birth.…”

Section: Introductionmentioning

confidence: 99%

“…The definition of symptom chronicity is dependent on age of presentation; at least 2 months is required if symptoms are evident at birth and at least 6 months if symptoms develop after birth. 1 Underlying etiologies may include neuropathic, myopathic, or both; prognosis is generally better with neuropathic etiologies. 2,3 Clinical diagnosis remains difficult and requires clinical, serum, radiologic, and gastrointestinal diagnostic studies.…”

Section: Introductionmentioning

confidence: 99%

“…Management of pediatric intestinal pseudo-obstruction remains conservative, with the focus on nutritional support, prokinetics, and antibiotic treatment. 1 If medical management fails, patients may require surgical intervention including, gastrostomy or central line placement for nutritional support, stoma for bowel irrigation, or creation of ostomy for decompression.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiology and healthcare utilization of inpatient admissions in children with pediatric intestinal pseudo‐obstruction

Batra

Rahman

Rana

et al. 2019

Neurogastroenterology Motil

View full text Add to dashboard Cite

Background Pediatric intestinal pseudo‐obstruction is a rare disorder affecting gastrointestinal motility leading to chronic symptoms and hospitalizations. There is limited understanding of the epidemiology and healthcare burden. Methods We analyzed data from Kids' Inpatient Database from 2016, which includes inpatient discharge records from US hospitals. ICD‐10 codes were used to identify patients 0‐18 years with pediatric intestinal pseudo‐obstruction and comorbid conditions. Multivariable logistic regression and Wilcoxon rank‐sum test were used. Results In 2016, there were 1671 inpatient discharges from US hospitals for patients 0‐18 years of age with this diagnosis. The incidence of inpatient admission was 29/100 000 patients. After controlling for age, race, income status, and insurance, males vs females (adjusted odds ratio, aOR: 1.10; 95% CI: 0.94‐1.28; P = .241) and caucasians vs other races (aOR: 1.55; 95% CI: 1.27‐1.88; P < .001) were more likely to be admitted. Inpatient admissions incurred significant healthcare burden; median (inter quartile range IQR) cost of hospitalization of US$ 52 079 (US$ 23 530‐120 961) and a median (IQR) length of stay of 6 days (3‐14 days). Gastrostomy (32%) and ileostomy (12.6%) status appeared to incur lower healthcare burden. Parenteral nutrition, malnutrition, and central line/bloodstream infections resulted in higher healthcare burden. Conclusions Pediatric intestinal pseudo‐obstruction is a rare diagnosis with a high incidence of inpatient admissions and healthcare burden. An aggressive multidisciplinary management is crucial in reducing inpatient admissions in this cohort.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology and healthcare utilization of inpatient admissions in children with pediatric intestinal pseudo‐obstruction

Batra

Rahman

Rana

et al. 2019

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…Major contributors to the disappointing lack of progress in pediatric CIPO include a dearth of clarity and uniformity across all aspects of clinical care from definition and diagnosis to management [4].…”

Section: Sbo Differ Substantially Colonic Malignancy Remains the Mosmentioning

confidence: 99%

The Clinical Presentations and Patterns of Management of Bowel Obstruction in Northern Saudi Arabia

Gharbi¹,

Shammari²,

Marshadi³

et al. 2018

View full text Add to dashboard Cite

Background: The prompt management of patients with bowel obstruction is essential and requires initial rapid diagnosis and therapeutic intervention. Therefore, the objective of the present study was to explore the clinical presentation and pattern of management of bowel obstruction in Northern Saudi Arabia. Methodology: About 92 files referring to patients presented with obstructive bowel conditions during the period from 2013 to 2017 were retrieved from department of surgery at King Khalid Hospital, Hail, Northern Saudi Arabia. Results: Most of cases of bowel obstruction were found in 2014, followed by 2013, 2016, and 28 of the patients presented with pain, constipation, vomiting, abdominal distention, bowel sound and accompanied disease, respectively. Conclusion: Laparotomy was the most common methods of bowel obstruction management in Northern Saudi Arabia. Many patients with bowel obstruction symptoms can improve without surgical intervention.

show abstract

Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition–Dependent Patient With Chronic Intestinal Pseudo‐Obstruction

Zemrani

Lambe²,

Goulet³

2020

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Chronic intestinal pseudo‐obstruction (CIPO) is a rare and challenging cause of pediatric intestinal failure, requiring long‐term parenteral nutrition in most cases. Despite optimal management, some patients experience chronic abdominal pain and recurrent obstructive episodes with a major impact on their quality of life. Cannabinoids have been successfully used in some conditions. However, their use in CIPO has never been reported in the literature. We report a case of successful use of medicinal cannabinoids in a patient with CIPO, resulting in a significant reduction of abdominal pain, vomiting, and subocclusive episodes and increased appetite and weight, without major adverse events. Although further observations are required to consolidate these findings, this case may be helpful for other patients suffering from the same condition.

show abstract

Paediatric Intestinal Pseudo‐obstruction

Cited by 113 publications

References 286 publications

Epidemiology and healthcare utilization of inpatient admissions in children with pediatric intestinal pseudo‐obstruction

Epidemiology and healthcare utilization of inpatient admissions in children with pediatric intestinal pseudo‐obstruction

The Clinical Presentations and Patterns of Management of Bowel Obstruction in Northern Saudi Arabia

Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition–Dependent Patient With Chronic Intestinal Pseudo‐Obstruction

Contact Info

Product

Resources

About