Estrogen receptor β activation within dorsal raphe nucleus reverses anxiety-like behavior induced by food restriction in female rats

Campos, Glenda; Noronha, Sylvana Rendeiro de; Souza, Aline Maria Arlindo de; Lima, Paulo Marcelo Andrade; Abreu, Aline Rezende; Chianca, Deoclécio A.; Menezes, Rodrigo Cunha Alvim de

doi:10.1016/j.bbr.2018.03.029

Cited by 14 publications

(11 citation statements)

References 50 publications

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“…However, in these animals, injections of tyrosine restored performance (Avraham et al, 1996). The second study showed that animals with food restriction showed more anxiety-like behavior than controls (Campos et al, 2019).…”

Section: Reduced Caloriesmentioning

confidence: 93%

“…Two studies used caloric restriction as a mean to investigate cognitive and behavioral effects of the reduced body weight in animals. The caloric intake was reduced to 60 and 40% of baseline caloric intake in mice in one study (Avraham et al, 1996) and to 40% of control animals' food intake in the second study (Campos et al, 2019). Cognitive function was evaluated using a modified eight-arm maze with rewards.…”

Section: Reduced Caloriesmentioning

confidence: 99%

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Animal Models for Anorexia Nervosa—A Systematic Review

Scharner

Stengel

2021

Front. Hum. Neurosci.

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Anorexia nervosa is an eating disorder characterized by intense fear of gaining weight and a distorted body image which usually leads to low caloric intake and hyperactivity. The underlying mechanism and pathogenesis of anorexia nervosa is still poorly understood. In order to learn more about the underlying pathophysiology of anorexia nervosa and to find further possible treatment options, several animal models mimicking anorexia nervosa have been developed. The aim of this review is to systematically search different databases and provide an overview of existing animal models and to discuss the current knowledge gained from animal models of anorexia nervosa. For the systematic data search, the Pubmed—Medline database, Embase database, and Web of Science database were searched. After removal of duplicates and the systematic process of selection, 108 original research papers were included in this systematic review. One hundred and six studies were performed with rodents and 2 on monkeys. Eighteen different animal models for anorexia nervosa were used in these studies. Parameters assessed in many studies were body weight, food intake, physical activity, cessation of the estrous cycle in female animals, behavioral changes, metabolic and hormonal alterations. The most commonly used animal model (75 of the studies) is the activity-based anorexia model in which typically young rodents are exposed to time-reduced access to food (a certain number of hours a day) with unrestricted access to a running wheel. Of the genetic animal models, one that is of particular interest is the anx/anx mice model. Animal models have so far contributed many findings to the understanding of mechanisms of hunger and satiety, physical activity and cognition in an underweight state and other mechanisms relevant for anorexia nervosa in humans.

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Section: Reduced Caloriesmentioning

confidence: 93%

Section: Reduced Caloriesmentioning

confidence: 99%

Animal Models for Anorexia Nervosa—A Systematic Review

Scharner

Stengel

2021

Front. Hum. Neurosci.

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“…Therefore, androgen metabolites might also induce effects on dorsal raphe serotonin neurons by binding ERβ, although this has not been directly tested. A recent study revealed that injections of DPN into the dorsal raphe reduced anxiety-like behaviors in food-restricted female rats, further implicating this as a key site of action for influencing behavioral stressresponses in rodents [196]. However, in non-foodrestricted female rats, dorsal raphe administration of DPN failed to alter anxiety-like behaviors [191].…”

Section: Anatomical Sites Of Action For Erβ Effects On the Hpa Axis Amentioning

confidence: 99%

Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

et al. 2020

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Estradiol and testosterone are powerful steroid hormones that impact brain function in numerous ways. During development, these hormones can act to program the adult brain in a male or female direction. During adulthood, gonadal steroid hormones can activate or inhibit brain regions to modulate adult functions. Sex differences in behavioral and neuroendocrine (i.e., hypothalamic pituitary adrenal (HPA) axis) responses to stress arise as a result of these organizational and activational actions. The sex differences that are present in the HPA and behavioral responses to stress are particularly important considering their role in maintaining homeostasis. Furthermore, dysregulation of these systems can underlie the sex biases in risk for complex, stress-related diseases that are found in humans. Although many studies have explored the role of estrogen and estrogen receptors in mediating sex differences in stress-related behaviors and HPA function, much less consideration has been given to the role of androgens. While circulating androgens can act by binding and activating androgen receptors, they can also act by metabolism to estrogenic molecules to impact estrogen signaling in the brain and periphery. This review focuses on androgens as an important hormone for modulating the HPA axis and behaviors throughout life and for setting up sex differences in key stress regulatory systems that could impact risk for disease in adulthood. In particular, impacts of androgens on neuropeptide systems known to play key roles in HPA and behavioral responses to stress (corticotropin-releasing factor, vasopressin, and oxytocin) are discussed. A greater knowledge of androgen action in the brain is key to understanding the neurobiology of stress in both sexes.

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“…Due to depleted energy reserves and to reduce its further expenditure, weight loss in anorexia is often accompanied by hypothalamic amenorrhea with inhibition of gonadotropin secretion and low estrogen levels. Although estrogen is known to inhibit food intake and seems to increase the serum leptin concentration, its deficiency in anorexia may also exaggerate anxiety [212]. Regulation of reproductive function seems to center around kisspeptin neurons that mediate metabolic signals and HPG feedback mechanisms (discussed in the hypothalamic regulation section of this review).…”

Section: Endocrine Dysregulationmentioning

confidence: 99%

Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa

et al. 2020

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Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.

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Estrogen receptor β activation within dorsal raphe nucleus reverses anxiety-like behavior induced by food restriction in female rats

Cited by 14 publications

References 50 publications

Animal Models for Anorexia Nervosa—A Systematic Review

Animal Models for Anorexia Nervosa—A Systematic Review

Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa

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