Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers—validation of technique and implications for clinical studies

Marzetti, Matthew; Brunton, Tracy; McCreight, Laura; Pearson, Ewan R.; Docherty, Stephen; Gandy, Stephen J.

doi:10.1259/bjr.20180025

Cited by 6 publications

(3 citation statements)

References 22 publications

(24 reference statements)

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“…Another strength of this study is that we used multiple measures of adiposity with different levels of granularity, ranging from anthropometric markers to overall body fatness and regional fat depots (superficial and deep). Importantly, when quantifying abdominal adipose tissue, we used whole abdomen volume which is more reproducible than partial abdomen measures or a single CT image.…”

Section: Discussionmentioning

confidence: 99%

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Ofori

Alonso

Correas-Gómez

et al. 2019

Clinical Endocrinology

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Summary Objective Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state‐of‐the‐art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women. Design Observational, cross‐sectional study of healthy, community dwelling postmenopausal women. Patients and Measurements Postmenopausal women (60‐80 years old) were included in this study. Overall body composition was evaluated by dual‐energy X‐ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography‐tandem mass spectrometry. Results Thirty‐five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05). Conclusion Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.

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Section: Discussionmentioning

confidence: 99%

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Ofori

Alonso

Correas-Gómez

et al. 2019

Clinical Endocrinology

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“…To further separate the VAT from other structures and organs within the abdominal cavity, a threshold was used. Only voxels above the cutoff value were considered adipose tissue and included in the VAT ROI [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants

Stenkula

Klemendz²,

Fryklund

et al. 2022

Lipids Health Dis

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Purpose Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.

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“…Инструментальные методы оценки степени висцерального ожирения занимают важное значение в диагностике и стратификации риска сердечно-сосудистых заболеваний [6]. Так, эталонным методом считаются томографические методики -компьютерная и магнитно-резонансная томография (МРТ) [7], а по некоторым данным, МРТ может превосходить компьютерную томографию в точности измерений [8].…”

Section: актуальностьunclassified

MRI assessment of the abdominal adipose tissue and the state of the abdominal aorta in patients with coronary artery disease: association with metabolic disorders

et al. 2021

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Aim. To evaluate potential associations between quantitative features of visceral and subcutaneous adipose tissue (AT) and anthropometric characteristics of obesity, metabolic disorders, and the state of the abdominal aorta in patients with chronic coronary artery disease (CAD).Materials and methods. The study included 55 patients (average age 61.2 ± 7.2 years) with chronic CAD. Magnetic resonance imaging (MRI) was performed on a 1.5 T MRI scanner using T2-weighted spin-echo modes. The area and volume of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) were calculated at the L4–L5 level; the total volumes of abdominal SAT and VAT were determined. Parameters of lipid and carbohydrate metabolism, as well as adipokine profile were studied in the blood serum.Results. In the course of a multiple linear regression analysis, we detected the independent determinants, which described 95% of the total VAT volume variability and were represented by waist circumference (WC) and serum levels of high-density lipoprotein (HDL) cholesterol and adiponectin. The model was characterized by the significance level p < 0.000001, the residuals of the model were normal. We calculated the coefficients in the model: 1.39 for WC, –0.26 for HDL cholesterol, and –0.19 for adiponectin. We detected a positive correlation between the abdominal aorta (AA) diameter and SAT area at the L4–L5 level (rs = 0.48; p = 0.0014), which does not depend on gender, and reverse correlations between the aorta diameter and glycated hemoglobin (HbA1c) level (rs = –0.40; p = 0.0359) and postprandial glycemia (rs = –0.40; p = 0.0273). The patients with a dilated aorta (group 2), when compared with the patients with a normal aorta diameter (group 1), did not differ in the AT accumulation, but demonstrated decreased levels of HbA1c and postprandial glycemia, which resulted in a smaller number of patients with type 2 diabetes mellitus.Conclusion. We identified independent determinants of an increase in the total volume of abdominal visceral AT, such as an increase in WC and a decrease in serum adiponectin and HDL cholesterol levels. Results of the study indicate the presence of a link between the AA remodeling, accumulation of subcutaneous AT, and impaired glucose metabolism.

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Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers—validation of technique and implications for clinical studies

Cited by 6 publications

References 22 publications

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants

MRI assessment of the abdominal adipose tissue and the state of the abdominal aorta in patients with coronary artery disease: association with metabolic disorders

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