Fluctuating Hearing Loss in the Only Hearing Ear: Cochlear Implantation in the Contralateral Deaf Side

Russo, Francesca; Seta, Daniele De; Lahlou, Ghizlène; Borel, Stéphanie; Nguyen, Yann; Bouccara, D.; Sterkers, Olivier; Bernardeschi, Danièle; Mosnier, Isabelle

doi:10.1177/0194599818763137

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As stated by Russo et al, 10 "when incapacitating fluctuating hearing loss occurs in patients presenting a contralateral deaf ear, a cochlear implant is indicated in the latter ear, significantly improving performance in noisy conditions and allowing a better quality of communication to be achieved. "…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, there are few references regarding cochlear implants in patients whose better ears also present some degree of hearing loss. 9,10 This situation can be quite complex, particularly when the hearing in the better ear is apt to progressively deteriorate. The same sort of consideration applies to patients with fluctuant hearing losses in their better ears, as during the episodes of more intense hearing loss, they experiment difficult social and professional situations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cochlear Implants in Patients with Fluctuant or Progressive Hearing Loss on the Better Ear

Albernaz

Malerbi

2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Cochlear implants have been proposed for cases of unilateral hearing loss, especially in patients with tinnitus impairment. Several studies have shown that they result in definite improvement of sound localization and speech understanding, both in quiet and noisy environments. On the other hand, there are few references regarding cochlear implants in patients whose better ears present hearing loss. Objective To report the audiological outcomes of three patients with unilateral deafness, in whom the better ears presented hearing losses, submitted to cochlear implants. Methods Three patients with unilateral profound hearing loss underwent a cochlear implant performed by the same surgeon. Results The patients' data are presented in detail. Conclusion The indications for cochlear implants are becoming more diverse with the expansion of clinical experience and the observation that they definitely help patients with special hearing problems.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cochlear Implants in Patients with Fluctuant or Progressive Hearing Loss on the Better Ear

Albernaz

Malerbi

2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Additionally, it was reported that one third of MD cases may have a dysfunction of the immune system (22). Although clinical symptoms of systemic autoimmune disorder were not present in patients who were suspected to have autoimmune pathology-associated MD, studies have identified in these patients an excessive immune response due to an attack of the specific inner ear structures by cochlear innate immune cells that recognize self-antigens, which leads to the release of inflammatory cytokines, including TNF-α, IL-1β, interferonγ (IFN-γ) and IL-17 (23)(24)(25). However, previous studies have shown that autoimmune inner ear disorder is confined mostly to the inner ear (23,24), and whether there is an association between the systemic immune system and local inflammation in the microenvironment of luminal fluid of the ES in patients with MD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Up-Regulated Expression of Interferon-Gamma, Interleukin-6 and Tumor Necrosis Factor-Alpha in the Endolymphatic Sac of Meniere's Disease Suggesting the Local Inflammatory Response Underlies the Mechanism of This Disease

et al. 2022

View full text Add to dashboard Cite

BackgroundImmune mediated inflammatory changes affecting the endolymphatic sac (ES) may underlie the pathology of Meniere's disease (MD). The aim of the present study was to explore the differentially expressed cytokines in ES luminal fluid (ELF) of patients with MD, and the correlation between the expression of cytokines in the ELF with that in the serum was determined by quantitatively analyzing the cytokines in human ELF and serum.MethodsHuman ELF, serum and ES tissues were collected from patients with unilateral MD and patients with acoustic neuroma (AN) during surgery. The Simoa Cytokine 6-Plex Panel kit was used to analyze the levels of cytokines in the ELF and blood samples of the patients. Immunohistochemistry and immunofluorescence were subsequently used to validate the relative expression levels of the cytokines in MD.ResultsSignificant differences were identified in the expression levels of interferon-γ (IFN-γ) (P < 0.001), interleukin (IL)-6 (P = 0.008) and tumor necrosis factor-α (TNF-α) (P = 0.036) in the luminal fluid of the ES comparing between the MD and AN groups. By contrast, the levels of IFN-γ, IL-10, IL-12p70, IL-17A, IL-6 and TNF-α in the serum of the MD group were not significantly different from those of either the AN group or healthy control subjects. In addition, no significant correlations in the expression levels of cytokines compared between the ELF and serum were found for the patients in either the MD or the AN group. Finally, the detection of positive expression of TNF-α, IL-6 and IFN-γ in the epithelial cells of the majority of ES specimens from patients with MD confirmed the up-regulated expression of these cytokines in the ES of patients with MD.ConclusionsThe identification of up-regulated expression levels of TNF-α, IL-6 and IFN-γ in the ELF in the present study has provided direct evidence for an increased immunologic activity in the microenvironment of the ES in patients with unilateral MD, may suggest the local inflammatory response underlies the mechanism of this disease.

show abstract

“…There is no evidence of efficacious medical therapy in the treatment of the MD, despite the many proposed drugs or techniques . Intratympanic therapies with steroid or gentamicin showed some evidence of efficacy; surgical therapy is currently indicated only for cases unresponsive to medical therapy …”

Section: Introductionmentioning

confidence: 99%

Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy

Attanasio

Califano

Bruno³

et al. 2019

The Laryngoscope

View full text Add to dashboard Cite

Objectives/Hypothesis To evaluate the incidence of chronic cerebrospinal venous insufficiency in Menière's disease patients and the effect of bilateral percutaneous transluminal angioplasty of the jugular/azygos veins compared to medical therapy. Study Design Prospective case–control study. Methods Five hundred fourteen subjects were included in the study, 412 affected by definite Menière's disease, and 102 healthy controls. All patients underwent audiovestibular and vascular examination. Patients with Menière's disease and concomitant cerebrospinal venous insufficiency were divided in two subgroups: patients who underwent vascular intervention with bilateral percutaneous transluminal angioplasty (PTA) of the jugular/azygos veins and patients treated with medical therapy. Results Chronic cerebrospinal venous insufficiency was diagnosed in 330/412 (80.1%) Menière's disease patients and in 12/102 healthy individuals (11.8%) (P < .001). In the two chronic cerebrospinal venous insufficiency subgroups, a significant difference in Dizziness Handicap Inventory scores was found between patients in the PTA group compared to patients treated with medical therapy (31 ± 8.6 vs. 48.1 ± 14.4; P < .001); no significant differences were found for the Tinnitus Handicap Inventory scores (50.8 ± 16.58 vs. 49.6 ± 17.5; P = .23). Subjective evaluation of aural fullness was significantly better in patients in the PTA group (P = .003) as well as pure‐tone average, which was significantly different between groups (49.8 ± 16.5 dB in the PTA group vs. 55.8 ± 13 in the medical therapy group; P = .035). Conclusions The results of the present study confirm the close relationship between vascular disorders and Menière's disease. The encouraging responses to vascular interventional therapy on Meniére's disease symptoms suggest that this may be a promising path for interpretation and treatment of this complex disease. Level of Evidence 2b Laryngoscope, 130: 2040–2046, 2020

show abstract

Fluctuating Hearing Loss in the Only Hearing Ear: Cochlear Implantation in the Contralateral Deaf Side

Cited by 6 publications

References 25 publications

Cochlear Implants in Patients with Fluctuant or Progressive Hearing Loss on the Better Ear

Cochlear Implants in Patients with Fluctuant or Progressive Hearing Loss on the Better Ear

Up-Regulated Expression of Interferon-Gamma, Interleukin-6 and Tumor Necrosis Factor-Alpha in the Endolymphatic Sac of Meniere's Disease Suggesting the Local Inflammatory Response Underlies the Mechanism of This Disease

Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy

Contact Info

Product

Resources

About