Oral supplementation of<i>Bifidobacterium longum</i>strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability

Makioka, Yuko; Tsukahara, Takamitsu; Ijichi, Tetsuo; Inoüe, Ryo

doi:10.1080/09168451.2018.1451738

Cited by 21 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maintaining a healthy intestinal microbiota colonization is critical for the host to keep normal physiological and psychological functions (Baothman et al., 2016; Inoue et al., 2016; Petra et al., 2015). The fetuses receive their first microbiota colony from their mothers in order for postnatal maturation of the immune system to occur (Finlay, 1990; Kim et al., 2017; Makioka et al., 2018). The quantity and quality of the maternal microbiota would not only affect the mother per se, but it would also affect offspring in their development and subsequent physiological functions (Kawase et al., 2017; Nishino et al., 2013).…”

Section: Introductionmentioning

confidence: 99%

Dysregulated metabolism and behaviors by disrupting gut microbiota in prenatal and neonatal mice

Han

Nishigawa

Ito

et al. 2021

Animal Science Journal

View full text Add to dashboard Cite

The live microbiota ecosystem in the intestine plays a critical role in maintaining the normal physiological and psychological functions in both animals and human beings. However, the chronic effect of microbiota disturbances during prenatal and neonatal developing periods on animal's health remains less studied. In the current study, pregnant ICR mice were fed with an antibiotic diet (7‐g nebacitin [bacitracin‐neomycin sulphate 2:1]/kg standard diet) from day 14 of conception, and their offspring were provided with the same diet till the termination of the experiments. Dams treated with antibiotics showed increased body weight along with enlarged gut. Antibiotic‐treated offspring revealed decreased bodyweight, increased food, water, and sucrose intake. Administration of antibiotics affected corticosterone responsivity to acute 20 min restraint challenge in male pups. In behavior tests, female pups showed decreased movement in open field while male pups revealed decreased latency to open arms in elevated plus maze test and immobility time in tail suspension test. Together, these results suggested that early antibiotic exposure may impact on the food intake, body weight gain, and emotional behavior regulation in mice.

show abstract

Section: Introductionmentioning

confidence: 99%

Dysregulated metabolism and behaviors by disrupting gut microbiota in prenatal and neonatal mice

Han

Nishigawa

Ito

et al. 2021

Animal Science Journal

View full text Add to dashboard Cite

show abstract

“…Unfortunately, we cannot explain why non-live OLB6378 intake increased the Bifidobacterium detection rate. Regarding this point, the effect of heat-killed Bifidobacterium longum BR-108 on mouse caecal microbiota is similar to that of viable BR-108, most likely because both heat-killed and viable BR-108 stimulate the gut immune system in similar manners [2]. We can only speculate that the Bifidobacterium detected in faeces was not the OLB6378 strain because the Bifidobacterium levels in the faeces (almost all were > 10 8 cells/g of faeces) were higher than the detection limit for the OLB6378 strain (10 7 cells/g of faeces).…”

Section: Discussionmentioning

confidence: 94%

“…Non-live Bifidobacterium is a safer and more convenient food material than live Bifidobacterium. Moreover, non-live Bifidobacterium cells stimulate the gut immune system in vitro and in vivo [1,2]. However, those effects have not been studied sufficiently in a clinical setting, especially in infants.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the intake of non-live <i>Bifidobacterium bifidum</i> on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study

Terahara

Nakamura

Tsuboi

et al. 2021

Bioscience of Microbiota, Food and Health

Self Cite

View full text Add to dashboard Cite

Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age.Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n = 45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n = 49) at four weeks of age (p = 0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake. IntroductionNon-live Bifidobacterium is a safer and more convenient food material than live Bifidobacterium. Moreover, non-live Bifidobacterium cells stimulate the gut immune system in vitro and in vivo [1,2]. However, those effects have not been studied sufficiently in a clinical setting, especially in infants. We selected Bifidobacterium bifidum OLB6378 (OLB6378), which enhances the production of secretory immunoglobulin A (IgA) [3], and confirmed the effect of non-live OLB6378 on enhancement of faecal IgA in low-birth-weight infants [4]. From the standpoint of trying to extend the versatility of non-live OLB6378, we hypothesised that non-live OLB6378 enhances the production of secretory IgA, even in full-term infants.However, the effect observed in low-birth-weight infants may not be observed in full-term infants. Preterm infants have lower body weights, heights, head circumferences, muscle and fat cross-sectional areas, and bone mineral densities than term-born infants [5]. With regard to nutrient digestion and absorption, premature infants do not have levels of intestinal lactase activity and gastric protein digestion capacities comparable to those of mature infants [6][7][8]. They also have immature immune systems and higher levels of intestinal permeability than term infants [9, 10]. Moreover, low birth weight is negatively associated with exclusive breastfeeding [11]. Given these differences between preterm and full-term infants, we considered that the effects of non-live OLB6378 should be demonstrated again in full-term infants.As a pilot study, we evaluated the effects of non-live OLB6378 administration on the enhancement of faecal IgA in full-term infants in this study. Materials and Methods Study Design and Ethical ApprovalThis was a double-blind, randomised, placebo-controlled study conducted among 100 newborn infants and their mothers. The protocol was approved by the Ethics Committee of Chiba Univers...

show abstract

“…Evidence of Bifidobacterium spp. in boosting immune systems has been demonstrated mostly in the mouse model, marked by the stimulation of IL-6 and IL-10 in the ileal Peyer's patches and in weaned pig model, marked by the increase of IgA against the parasite and IgG 34,35 . 42 .…”

Section: Mechanisms Of Probiotics In Interfering With Pathogens and Imentioning

confidence: 99%

The relevance of probiotics in Caesarean-born neonates

et al. 2020

View full text Add to dashboard Cite

There is growing interest in the use of probiotics in neonates. In particular, Lactobacillus rhamnosus, L. acidophilus, Bifidobacterium breve and B. longum have been well studied. Caesarean-section (CS)-born infants often lack Lactobacillus spp. and Bifidobacterium spp., which showed increasing evidence in establishing the neonatal immune system. Furthermore, CS increases the difficulties for mothers in initiating and sustaining breastfeeding. Increasing evidence shows CS-born infants are more susceptible to allergy, infections and chronic inflammatory diseases later in life. The number of CS births has increased continuously, now accounting for 35% of all deliveries Australia wide. In this context, probiotics may have a role in establishing a healthy neonatal gut microbiome.

show abstract

Oral supplementation ofBifidobacterium longumstrain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability

Cited by 21 publications

References 36 publications

Dysregulated metabolism and behaviors by disrupting gut microbiota in prenatal and neonatal mice

Dysregulated metabolism and behaviors by disrupting gut microbiota in prenatal and neonatal mice

Effects of the intake of non-live <i>Bifidobacterium bifidum</i> on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study

The relevance of probiotics in Caesarean-born neonates

Contact Info

Product

Resources

About