Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia

Poos, Jackie M.; Jiskoot, Lize C.; Papma, Janne M.; Swieten, John C. van; Berg, Esther van den

doi:10.1017/s1355617718000115

Cited by 33 publications

(18 citation statements)

References 90 publications

(86 reference statements)

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“…The FCSRT is commonly used by neuropsychologists as it involved both free and cued-based recalls, thus allowing us to tackle the commonest criticize made to studies only addressing free recall. In addition, the poor discrimination power of memory testing in the context of the differential diagnosis between AD and FTLD, although it was never the focus of a neuropathological study before, has been shown independently of the test used and the memory component explored (Bertoux et al 2018;Poos et al, 2018). In consequence, we believe that it is likely that our findings could be generalizable with other common verbal memory assessment.…”

Section: Discussionmentioning

confidence: 67%

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Bertoux¹,

Cassagnaud

Lebouvier

et al. 2020

Neurobiology of Aging

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Amnesia is a key component of Alzheimer's disease (AD) and the most important feature of its clinical diagnosis but its specificity has recently been challenged. This study investigated the ability of amnesia to predict AD in a clinicopathological dementia series. Ninety-one patients to which free and cued verbal memory assessment was administered during early cognitive decline, were followed until autopsy. Patients' histological diagnoses were classified as pure-AD, mixed-AD and non-AD pathologies. Data-driven automated classification procedures explored the correspondence between memory performance and pathological diagnoses. Classifications revealed three clusters of performance reflecting different levels of amnesia. Little correspondence between these clusters and the presence of AD pathology was retrieved. A third of patients with pure/mixed AD pathology were nonamnesic at presentation and ≈45% of patients without AD pathology were amnesic. Datadriven prediction of AD pathology based on memory also had a poor accuracy. Free and cued memory assessments are fair tools to diagnose an amnesic syndrome but lack of accuracy to predict AD pathology.

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Section: Discussionmentioning

confidence: 67%

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Bertoux¹,

Cassagnaud

Lebouvier

et al. 2020

Neurobiology of Aging

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“…Consensual diagnostic criteria for bvFTD state that episodic memory is relatively spared in bvFTD [2]. However, there is increasing evidence that episodic memory impairment occurs in bvFTD [37, 38] in a similar degree as observed in Alzheimer’s disease [19, 27, 39–41]. Actually, amnesia in bvFTD is associated with the involvement of medial temporal structures, such as hippocampal and perihippocampal regions [37, 39–41].…”

Section: Discussionmentioning

confidence: 99%

Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review

et al. 2019

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Background The phenocopy syndrome of behavioral variant of frontotemporal dementia (phFTD) refers to patients presenting with neuropsychiatric symptoms mimicking the behavioral variant frontotemporal dementia (bvFTD), but lacking frontotemporal atrophy/hypometabolism on neuroimaging and not evolving to dementia during the follow-up. It is important to recognize phFTD for clinical and research purposes. Objective The aim of this study was to perform a systematic review of the available literature on phFTD taking into account its clinical, cognitive, imaging, genetic, and pathological features. Methods and results We searched for the following terms in two electronic databases (PubMed and Scopus): “frontotemporal dementia and slowly progressive,” “frontotemporal dementia and phenocopy,” “frontotemporal dementia and non-progressive,” “frontotemporal dementia and benign progression,” and “frontotemporal dementia and benign.” We did not include review articles. Papers had to be written in English, French, Portuguese, or Spanish. Overall, 235 studies were retrieved in the initial search. A total of 31 studies composed the final selection, comprising 292 patients. Patients with phFTD are predominantly male and have no major cognitive deficits, with globally preserved executive functions and episodic memory. Some cases ( n = 7) of slowly progressive FTD have been associated with C9orf72 genetic expansion. There are only four reports of phFTD neuropathological data, with two patients with no neurodegenerative findings and two with frontotemporal lobar degeneration with ubiquitin-positive inclusions. Conclusion The neurobiological underpinnings of phFTD remain unknown. It is controversial whether phFTD belongs to the FTD spectrum. Studies with biomarkers and pathological data are needed to solve the phFTD conundrum.

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“…The clinical profile of FTD is typically characterized by behavioural and language disturbances, with cognitive deficits in executive function and relative sparing of memory and visuospatial abilities [ 1 , 2 ], whereas the first symptoms of AD are usually episodic memory and visuospatial impairments [ 3 ]. Differential diagnosis in a young-onset population is complicated by frequent atypical presentations and clinical overlap between the two entities, with significant memory deficits in FTD [ 4 ], and predominant ‘frontal’ (dysexecutive and behavioural) and language variants of AD being described [ 5 ], often leading to misdiagnosis and/or diagnostic delay. Early diagnosis is, however, essential for proper patient and caregiver management and planning, non-pharmacological symptomatic treatment, and patient stratification in upcoming clinical trials [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer’s dementia

et al. 2020

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Background The emotion recognition task (ERT) was developed to overcome shortcomings of static emotion recognition paradigms, by identifying more subtle deficits in emotion recognition across different intensity levels. In this study, we used the ERT to investigate emotion recognition deficits across the frontotemporal (FTD) and Alzheimer’s Dementia (AD) spectrum. Methods With the ERT, we assessed the recognition of facial emotional expressions (anger-disgust-fear-happiness-sadness-surprise) across four intensities (40–60–80–100%) in patients with behavioural variant FTD (bvFTD; n = 32), and AD ( n = 32), presymptomatic FTD mutation carriers ( n = 47) and controls ( n = 49). We examined group differences using multilevel linear regression with age, sex and education level as covariates, and performed post hoc analyses on presymptomatic ( MAPT , GRN and C9orf72 ) mutation carriers. Classification abilities were investigated by means of logistic regression. Results Lowest ERT total scores were found in patients with bvFTD and AD, whereas equal highest performance was found in presymptomatic mutation carriers and controls. For all emotions, significantly lower subscores were found in patients with bvFTD than in presymptomatic mutation carriers and in controls (highest p value = 0.025). Patients with bvFTD performed lower than patients with AD on anger ( p = 0.005) and a trend towards significance was found for a lower performance on happiness ( p = 0.065). Task performance increased with higher emotional intensity, and classification was better at the lowest than at the highest intensity. C9orf72 mutation carriers performed worse on recognizing anger at the lowest intensity than GRN mutation carriers ( p = 0.047) and controls ( p = 0.038). The ERT differentiated between patients with bvFTD and controls, and between patients with AD and controls (both p < 0.001). Discussion Our results demonstrate emotion recognition deficits in both bvFTD and AD, and suggest the presence of subtle emotion recognition changes in presymptomatic C9orf72 -FTD. This highlights the importance of incorporating emotion recognition paradigms into standard neuropsychological assessment for early differential diagnosis, and as clinical endpoints in upcoming therapeutic trials. Electronic supplementary material The online version of this article (10.1007/s00415-020-10096-y) contains supplementary material, which is available to authorized users.

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Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia

Cited by 33 publications

References 90 publications

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review

Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer’s dementia

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