Polyphenol bioavailability in nuts and seeds by an in vitro dialyzability approach

Herbello-Hermelo, Paloma; Lamas, J. Pablo; Lores, Marta; Domínguez-González, Raquel; Bermejo–Barrera, Pilar; Moreda–Piñeiro, Antonio

doi:10.1016/j.foodchem.2018.01.183

Cited by 38 publications

(21 citation statements)

References 38 publications

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“…Compared to other nuts, pistachios have a higher amount of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) [9,13,14]. They are rich in phytosterols (stigmasterol and campesterol), lutein (xanthophyll carotenoid), and polyphenols (resveratrol and catechins) [9,10,11,12,13,14,15]. These substances are known for their anti-inflammatory and antioxidant actions [9,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice

et al. 2018

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Pistachios contain beneficial substances such as unsaturated fatty acids, phytosterols, and polyphenols. In the present study, we investigated if pistachio consumption is able to prevent or to revert hyperglycemia, dyslipidemia, hepatic steatosis, and adipose tissue morphological alterations caused by high fat diet (HFD) in the mouse. Moreover, the impact of pistachio intake on the mRNA expression of peroxisome proliferator-activated receptor γ (PPAR-γ), fatty acid transport proteins (FAT-P), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD1), and sterol regulatory element-binding transcription factor-1c (SREBP-1c) in liver and adipose tissue was also analyzed. No change in body weight, food intake, and hyperglycemia was observed between mice consuming pistachios (HFD-P) and HFD mice. Pistachio intake was able to prevent but not to reverse HFD-induced hypertriglyceridemia. Cholesterol plasma levels, steatosis grading, body fat mass, and adipocyte size were significantly lower in HFD-P group compared to HFD in both prevention and reversal protocol. Pistachio-diet was able to prevent HFD-induced overexpression of PPAR-γ, FAS, and SCD1 in the liver and SREBP-1c, PPAR-γ, and FAT-P in adipose tissue. Similarly, HFD-P significantly ameliorated the expression levels of FAT-P and SCD1 in the liver and SREBP-1c, FAS, and SCD1 in adipose tissue of obese mice. The present study shows that pistachio consumption is able to prevent and to ameliorate obesity-related dysfunctions by positively modulating the expression of genes linked to lipid metabolism.

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Section: Introductionmentioning

confidence: 99%

Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice

et al. 2018

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“…In case of cashews, pistachios, and Brazil nuts with low/moderate total phenolic contents, high bioavailable ratios (80-90%) have been found. Analysis of these results gave a correlation between TP bioavailability and Cu concentration in investigated nuts/seeds [189]. The most abundant phenolic compounds in our diet are not necessarily those that have the best bioavailability profile.…”

Section: Polyphenol Bioavailabilitymentioning

confidence: 87%

“…New in vitro dialyzability approaches applied in order to investigate total phenolics bioavailability in intestinal absorption process have been published [189]. Analyzed nuts and seeds with high phenolic contents, like walnuts and goji berries, showed low total phenolics dialyzability.…”

Section: Polyphenol Bioavailabilitymentioning

confidence: 99%

Polyphenols as Possible Agents for Pancreatic Diseases

Gašić

Ćirić

Pejcic³

et al. 2020

Antioxidants

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Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.

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“…Thus, their high unsaturated fatty acid content induces the reduction of both total and low-density lipoprotein cholesterols [3], correlating their consumption to the decrease of ischemic heart disease [4]. They have also been shown to be important sources of antioxidant compounds, such as polyphenols [5,6,7,8], which are secondary metabolites and the largest group of phytochemicals in plants. In fact, the main dietary sources of total polyphenols are nuts, followed by tea and coffee, rich in flavanols and hydroxycinnamic acids, respectively [9].…”

Section: Introductionmentioning

confidence: 99%

Non-Targeted HPLC-UV Fingerprinting as Chemical Descriptors for the Classification and Authentication of Nuts by Multivariate Chemometric Methods

Campmajó

Navarro

Núñez

et al. 2019

Sensors

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Recently, the authenticity of food products has become a great social concern. Considering the complexity of the food chain and that many players are involved between production and consumption; food adulteration practices are rising as it is easy to conduct fraud without being detected. This is the case for nut fruit processed products, such as almond flours, that can be adulterated with cheaper nuts (hazelnuts or peanuts), giving rise to not only economic fraud but also important effects on human health. Non-targeted HPLC-UV chromatographic fingerprints were evaluated as chemical descriptors to achieve nut sample characterization and classification using multivariate chemometric methods. Nut samples were extracted by sonication and centrifugation, and defatted with hexane; extracting procedure and conditions were optimized to maximize the generation of enough discriminant features. The obtained HPLC-UV chromatographic fingerprints were then analyzed by means of principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) to carry out the classification of nut samples. The proposed methodology allowed the classification of samples not only according to the type of nut but also based on the nut thermal treatment employed (natural, fried or toasted products).

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Polyphenol bioavailability in nuts and seeds by an in vitro dialyzability approach

Cited by 38 publications

References 38 publications

Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice

Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice

Polyphenols as Possible Agents for Pancreatic Diseases

Non-Targeted HPLC-UV Fingerprinting as Chemical Descriptors for the Classification and Authentication of Nuts by Multivariate Chemometric Methods

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