Microscopic colitis in patients with ulcerative colitis or Crohn’s disease: a retrospective observational study and review of the literature

Wickbom, Anders; Bohr, Johan; Nyhlin, Nils; Eriksson, Anders; Lapidus, Annika; Münch, Andreas; Ung, Kjell-Arne; Vigren, Lina; Öst, Åke; Tysk, Curt

doi:10.1080/00365521.2018.1430252

Cited by 23 publications

(19 citation statements)

References 54 publications

(113 reference statements)

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“…Several exposures that have been associated with inflammatory bowel disease (IBD), such as non-steroid anti-inflammatory drugs and smoking, have also been associated with CC (1). Interestingly, CC has been described to convert into IBD or vice versa (6–10). These observations suggest that CC and IBD might have pathophysiologic mechanisms in common.…”

Section: Introductionmentioning

confidence: 99%

The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis

Carstens

Dicksved

Nelson

et al. 2019

Clin Transl Gastroenterol

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INTRODUCTION: In inflammatory bowel disease (IBD), an aberrant immune response to gut microbiota is important, but the role of the microbiota in collagenous colitis (CC) is largely unknown. We aimed to characterize the microbiota of patients with CC compared with that of healthy control and patients with IBD. METHODS: Fecal samples were collected from patients with CC (n = 29), age- and sex-matched healthy controls (n = 29), patients with Crohn's disease (n = 32), and patients with ulcerative colitis (n = 32). Sequence data were obtained by 454 sequencing of 16S rRNA gene amplicons, and the obtained sequences were subsequently taxonomically classified. RESULTS: Analysis of similarity statistics showed a segregation between patients with CC and healthy controls with increasing taxonomic resolution, becoming significant comparing operational taxonomic unit data ( P = 0.006). CC had a lower abundance of 10 different taxa. Taxa-specific analyses revealed a consistent lower abundance of several operational taxonomic units belonging to the Ruminococcaceae family in patients with CC, q < 0.05 after false discovery rate correction. Loss of these taxa was seen in patients with CC with active disease and/or corticosteroid treatment only and resembled the findings in patients with IBD. DISCUSSION: CC is associated with a specific fecal microbiome seen primarily in patients with active disease or ongoing corticosteroid treatment, whereas the microbiome of CC patients in remission resembled that of healthy controls. Notably, the shift in key taxa, including the Ruminococcaceae family, was also observed in IBD. There may be common mechanisms in the pathogenesis of CC and IBD.

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Section: Introductionmentioning

confidence: 99%

The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis

Carstens

Dicksved

Nelson

et al. 2019

Clin Transl Gastroenterol

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Section: Discussionmentioning

confidence: 99%

“…A review of the scientific literature indicates 58 confirmed cases in the past 30 years of MC diagnosed in patients before or after a diagnosis of IBD 4,5,13. Of these cases, only 11 were of patients diagnosed with LC and UC 4,5,13. One case series identified 4 patients with UC in remission who subsequently developed LC, while another case series reported 2 patients initially diagnosed with LC who later developed UC 4,5,13.…”

Section: Discussionmentioning

confidence: 99%

“…Of these cases, only 11 were of patients diagnosed with LC and UC 4,5,13. One case series identified 4 patients with UC in remission who subsequently developed LC, while another case series reported 2 patients initially diagnosed with LC who later developed UC 4,5,13. A 2018 retrospective observational study and review reports 5 cases of LC in women previously diagnosed with UC; 4 of the 5 patients were diagnosed with extensive colitis 13.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, antecedent reports indicate that patients with MC and IBD may share similar genetics and that MC may share a common pathophysiology with IBD, namely a dysregulated immune response to the gut microbiome in genetically susceptible individuals 1-5,12. Finally, a recent review suggests patients originally diagnosed with extensive UC may be more prone to developing LC compared to patients with limited left-sided and proctosigmoid involvement of UC 13…”

Section: Discussionmentioning

confidence: 99%

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Lymphocytic Colitis Diagnosis 40 Years after Onset of Ulcerative Colitis

Stavrakis

Meiklejohn

Taleban

2018

ACG Case Reports Journal

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Lymphocytic colitis is a subtype of microscopic colitis characterized by normal colonoscopy findings and microscopic evidence of lymphocytic infiltration of colonic epithelial cells. The concomitant diagnosis of lymphocytic colitis and ulcerative colitis has been rarely reported. We present a 68-year-old man with a 40-year history of ulcerative colitis who was referred to our hospital for 3–4 weeks of non-bloody diarrhea with subsequent colonoscopy and biopsies confirming lymphocytic colitis.

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Gluten‐Free Diet in IBD: Time for a Recommendation?

Weaver

Herfarth

2020

Molecular Nutrition Food Res

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Patients and providers alike are highly interested in identifying potentially useful dietary interventions in the management of inflammatory bowel diseases (IBD). This review examines the clinical associations of celiac disease (CeD), non‐celiac gluten sensitivity (NCGS), and IBD with a focus on available data of the therapeutic efficacy of gluten‐free diet (GFD) or low‐gluten‐containing diets in the therapy of IBD. There is a strong association between CeD and microscopic colitis, but the prevalence of CeD among IBD patients is similar to that of the general population. Interestingly, in cross‐sectional studies nearly one‐third of IBD patients report a diagnosis of NCGS, and many follow a GFD. Although animal studies have shown that gluten ingestion may promote intestinal inflammation and increase intestinal permeability, there have been no prospective studies evaluating the role of a GFD in the induction and maintenance of Crohn's disease and ulcerative colitis. Several cross‐sectional reports suggest that a GFD may improve symptoms in IBD patients, but due to a lack of high‐quality prospective clinical studies, current data do not support the universal use of a GFD in IBD.

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Microscopic colitis in patients with ulcerative colitis or Crohn’s disease: a retrospective observational study and review of the literature

Cited by 23 publications

References 54 publications

The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis

The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis

Lymphocytic Colitis Diagnosis 40 Years after Onset of Ulcerative Colitis

Gluten‐Free Diet in IBD: Time for a Recommendation?

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