Helicobacter Pylori Infection Does Not Protect Against Eosinophilic Esophagitis: Results From a Large Multicenter Case-Control Study

Molina–Infante, Javier; Gutiérrez-Junquera, Carolina; Savarino, Edoardo; Penagini, Roberto; Modolell, Inés; Bartolo, Ottavia; Prieto-García, Alicia; Mauro, Aurelio; Alcedo, Javier; Perelló, Antonia; Guarner-Argente, Carlos; Alcaide, Noelia; Vegas, Ana María; Barros-García, Patricia; Murzi-Pulgar, Marianette; Perona, Mónica; Gisbert, Javier P.; Lucendo, Alfredo J.

doi:10.1038/s41395-018-0035-6

Cited by 59 publications

(41 citation statements)

References 35 publications

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“…Therefore, the current eradication protocol will not bring adverse consequences commonly associated with antibiotic use, such as obesity, gastroesophageal reflux disease, irritable bowel disease, or allergic asthma. Some studies have suggested that H. pylori has a protective effect on eosinophilic esophagitis, but more recent studies have more or less debunked this notion …”

Section: Helicobacter Pylori Eradication and Gastric Cancer Preventionmentioning

confidence: 99%

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Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Liu

et al. 2020

J of Gastro and Hepatol

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Background and Aim China is a country with high prevalence of Helicobacter pylori (H. pylori) infection, which in turn is closely related to the occurrence of gastric cancer. Therefore, the risks of H. pylori infection and gastric cancer are highly overlapping, and the prevention and treatment of H. pylori infection are necessary to prevent gastric cancer. Methods Based on evidence‐based medicine and the Delphi method, the National Clinical Medical Research Center for Digestive Disease along with the National Early Gastrointestinal Cancer Prevention and Treatment Center Alliance organized dozens of experts in the fields of digestive diseases, H. pylori research, gastric cancer surgery, epidemiology, health economics, and health management to discuss the relationship between H. pylori eradication and prevention and the treatment of gastric cancer. Results A preliminary consensus on the relationship between H. pylori infection and gastric cancer, H. pylori eradication and gastric cancer prevention, and H. pylori screening and eradication strategy was reached. The consensus further clarified the relationship between H. pylori and gastric cancer and how to formulate future prevention and control strategies for gastric cancer. Conclusions This consensus could provide guidance on early detection, diagnosis, and treatment of H. pylori to reduce the occurrence of gastric cancer in China.

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Section: Helicobacter Pylori Eradication and Gastric Cancer Preventionmentioning

confidence: 99%

“…Some studies have suggested that H. pylori has a protective effect on eosinophilic esophagitis, but more recent studies have more or less debunked this notion. 35…”

Section: Helicobacter Pylori Eradication and Gastric Cancer Preventionmentioning

confidence: 99%

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Liu

et al. 2020

J of Gastro and Hepatol

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“…They are considered to be caused by chronic allergic reactions to various allergens, including food and environmental antigens. The pathogenesis of EoE has yet to be completely elucidated, with both genetic and environmental factors considered to be involved [ 20 , 21 , 22 ]. In case of EoE, medical therapies consist primarily of oral proton pump inhibitors, elimination diet or orally administered topical corticosteroids, whereas immunosuppressive or immunomodulatory drugs, such as systemic corticosteroids and biologic therapies, are more frequently prescribed in patients with EGE or EC [ 6 , 7 , 8 , 19 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 Outbreak

Savarino

Iovino

Santonicola

et al. 2020

JCM

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Eosinophilic gastrointestinal diseases (EGIDs) are chronic gastrointestinal conditions requiring corticosteroid and immunosuppressive therapy for disease control. Patients with EGIDs usually report impaired quality of life. We aimed to report the clinical and psychological impact of COVID-19 infection in EGID patients. In this prospective web-based study we invited all consecutive EGID patients attending the University Hospital of Salerno (Campania) and Padua (Veneto) to fill an ad hoc COVID-19 survey. Moreover, a telemedicine service for direct consultation was organized. Data regarding the occurrence and perception of COVID-19 infection as well as clinical information were recorded. The study population included 102 EGID patients (mean age 36.6 years, 34 females), of whom 89 had eosinophilic esophagitis, nine had gastroenteritis, and four had colitis. No patient was diagnosed with COVID-19 or had recurrence of his/her primary disease. All of them were adherent to therapy and preventive measures adoption. Most patients were worried because of COVID-19 and social preventing measures but did not consider themselves at major risk or susceptible to COVID-19 or other infections due to their chronic condition or therapy. Female gender and low education level were associated to a higher psychological perception of COVID-19 compared to lockdown status or other demographic and clinical factors (p < 0.05). Overall, COVID-19 had a limited clinical impact on patients with EGIDs. The degree of education and sex, but not the fact of living in a lockdown area, influenced the perception of SARS-CoV-2 infection.

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“…A large prospective multicenter case‐control study was conducted in Spain, Italy, France, and Colombia (N = 808), in order to investigate a possible association between H pylori infection and eosinophilic esophagitis (EoE) . No significant difference in the prevalence of H pylori infection was identified between cases and controls in children (42% vs 46%), questioning an inverse association of H pylori and EoE.…”

Section: Clinical Presentationmentioning

confidence: 99%

Review: Helicobacter pylori in pediatrics

2019

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Despite a decrease in the prevalence of Helicobacter pylori infection, it still poses a significant health burden worldwide. This review summarizes important pediatric studies on H pylori published from April 2018 to March 2019. Epidemiologic studies have reported different prevalences in different parts of the world and have mainly confirmed traditional risk factors. Several studies on pathophysiology attempted to identify risk markers in childhood for gastric cancer development later in life. One of the most interesting studies evaluated the relationship between eosinophilic esophagitis and H pylori infection; however, an inverse relationship was not confirmed. The high resistance of H pylori and, consequently, low eradication rates, is still a major concern and susceptibility testing before treatment has again been highlighted. Potassium‐competitive acid blockers are promising new acid‐suppressant drugs but their role in H pylori eradication schemes is still to be determined.

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Helicobacter Pylori Infection Does Not Protect Against Eosinophilic Esophagitis: Results From a Large Multicenter Case-Control Study

Cited by 59 publications

References 35 publications

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 Outbreak

Review: Helicobacter pylori in pediatrics

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