Detection and characterization of a novel spotted fever group Rickettsia genotype in Haemaphysalis leporispalustris from California, USA

Eremeeva, Marina E.; Weiner, Lindsey M.; Zambrano, Maria L.; Dasch, Gregory A.; Hu, Renjie; Vilcins, Inger-Marie E; Castro, Martin B.; Bonilla, Denise L.; Padgett, Kerry A.

doi:10.1016/j.ttbdis.2018.02.023

Cited by 12 publications

(9 citation statements)

References 48 publications

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“…Ticks are the main vectors and constitute a threat of rickettsial infection regardless of their development stage (larvae, nymphs, or adults). Many factors play a role in the epidemiology of tick-borne rickettsioses, including the prevalence and species diversity of rickettsiae in mammals [149–153] and the dispersion of infected ticks by migratory birds [154]. …”

Section: Epidemiology Of Rickettsial Diseasesmentioning

confidence: 99%

Rickettsial infections of the central nervous system

et al. 2019

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As a result of migrations and globalization, people may face a possible increase in the incidence of central nervous system rickettsial infections (CNS R). These diseases, caused by Rickettsia species and transmitted to humans by arthropod bites, are putatively lethal. However, the diagnosis of CNS R is challenging and often delayed due to their nonspecific clinical presentation and the strict intracellular nature of rickettsiae. Furthermore, transfer of rickettsiae to the brain parenchyma is not yet understood. The aim of this review is to analyze and summarize the features and correlated findings of CNS R in order to focus attention on these intriguing but frequently neglected illnesses. We also incorporated data on CNS infections caused by Rickettsia- related microorganisms.

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Section: Epidemiology Of Rickettsial Diseasesmentioning

confidence: 99%

Rickettsial infections of the central nervous system

et al. 2019

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“…In this respect, previous studies carried out in America suggested that wild lagomorphs may play an important role in the maintenance of some Rickettsia species due to their long‐lasting asymptomatic rickettsiaemia (Rovery et al., 2008). Even though in this continent some Rickettsia strains detected in ticks collected from rabbits were identified as avirulent (Eremeeva et al., 2018; Roth et al., 2017), Rickettsia rickettsii strains identical to those previously detected in human clinical samples were also identified in Haemaphysalis leporispalustris collected from these lagomorphs in Costa Rica (Hun et al., 2008). The aims of the present study were (a) to identify tick species parasitizing wild rabbits and Iberian hares in Mediterranean ecosystems in southern Spain and (b) to detect and identify the Rickettsia species present in ticks parasitizing these wild lagomorph species.…”

Section: Introductionmentioning

confidence: 98%

Molecular identification of zoonotic Rickettsia species in Ixodidae parasitizing wild lagomorphs from Mediterranean ecosystems

Remesar

Castro‐Scholten

Cano‐Terriza

et al. 2021

Transbounding Emerging Dis

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A survey study was carried out to identify tick species parasitizing wild lagomorphs in Mediterranean ecosystems in southern Spain and to determine the occurrence of Rickettsia species present in these ticks in this region. A total of 1304 European wild rabbits (Oryctolagus cuniculus) and 58 Iberian hares (Lepus granatensis) were individually examined for the presence of ticks. Ticks were found in 42.9% and 50% of the wild rabbits and hares sampled, respectively. A total of 1122 ticks were collected and five species, including Rhipicephalus pusillus, Hyalomma lusitanicum, Haemaphysalis hispanica, Ixodes ventalloi and Rhipicephalus sanguineus sensu lato (s.l.), were microscopically and molecularly identified at the 16S rRNA gene. This is the first study on Ixodidae parasitizing Iberian hares. The presence of Rickettsia DNA was assessed in 254 tick pools (according to hunting states, lagomorph species, tick species and tick development stage) using PCR assays targeting the rOmpA, rOmpB and gltA. Twenty-seven pools (10.6%) were positive to Rickettsia DNA. Five zoonotic Rickettsia species were identified, being Rickettsia massiliae the most frequent (4.7%), followed by Rickettsia sibirica subsp. mongolitimonae (2.8%), Rickettsia slovaca (2.0%), Rickettsia aeschlimannii (0.8%) and Rickettsia africae (0.4%). The results suggest that wild rabbits and Iberian hares are parasitized by a wide range of tick species and that these lagomorphs may play an important role in the sylvatic cycle of some zoonotic Rickettsia species in Mediterranean ecosystems. Our data represent the first report of R. massiliae, R.

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“…Another genetic near neighbor of R. rickettsii , Rickettsia sp. CA6269, recently was reported in rabbit ticks ( Haemaphysalis leporispalustris ) collected in Northern California ( 11 ). Multilocus sequence typing (MLST) of that strain revealed a novel genotype having sufficient sequence divergence from R. rickettsii to lead the investigators to propose a new species, Candidatus Rickettsia lanei.…”

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confidence: 94%

Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever–Like Illness, Northern California, USA

Probert,

Haw,

Nichol

et al. 2024

Emerg. Infect. Dis.

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The incidence of spotted fever group (SFG) rickettsioses in the United States has tripled since 2010. Rocky Mountain spotted fever, the most severe SFG rickettsiosis, is caused by Rickettsia rickettsii . The lack of species-specific confirmatory testing obfuscates the relative contribution of R. rickettsii and other SFG Rickettsia to this increase. We report a newly recognized rickettsial pathogen, Rickettsia sp. CA6269, as the cause of severe Rocky Mountain spotted fever–like illness in 2 case-patients residing in northern California. Multilocus sequence typing supported the recognition of this pathogen as a novel Rickettsia genotype most closely related to R. rickettsii . Cross-reactivity observed for an established molecular diagnostic test indicated that Rickettsia sp. CA6269 might be misidentified as R. rickettsii . We developed a Rickettsia sp. CA6269–specific real-time PCR to help resolve this diagnostic challenge and better characterize the spectrum of clinical disease and ecologic epidemiology of this pathogen.

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Detection and characterization of a novel spotted fever group Rickettsia genotype in Haemaphysalis leporispalustris from California, USA

Cited by 12 publications

References 48 publications

Rickettsial infections of the central nervous system

Rickettsial infections of the central nervous system

Molecular identification of zoonotic Rickettsia species in Ixodidae parasitizing wild lagomorphs from Mediterranean ecosystems

Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever–Like Illness, Northern California, USA

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