The use of platelet gel for repair of a cerebrospinal fluid fistula of the skull base (a case report and literature review)

Sharipov, Oleg; Kutin, Maxim; Bayuklin, A V; Imaev, A.; Abdilatipov, A A; Kurnosov, A B; Fomichev, Dmitry; Mikhaylov, N I; Kalinin, Pavel

doi:10.17116/neiro201882186-92

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…All examined patients underwent plastic surgery of the cerebrospinal fluid fistula with endoscopic endonasal approach. When closing the cerebrospinal fluid fistula, which was located in the region of the sieve plate, up to 5 mm in size, in 19 cases there was used a combination of an adsorbing haemostatic substance (Tachocomb®) [ Figure 3] and fibrin-thrombin surgical glue Tissucol [17].…”

Section: Methodsmentioning

confidence: 99%

Transsphenoidal Endoscopic Approach in Treatment of Spontaneous Nasal CSF-leak

Karpishchenko¹,

Cherebillo²,

Vereshchagina³

et al. 2019

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Spontaneous nasal liquorrhea is a pathological condition associated with defects between the nasal cavity and the intracranial structures, which results in CSF leak from the nasal cavity. Diagnostic criteria include: anamnesis, examination of the nasal fluid, endoscopic examination of the nasal cavity, and CT-and MRI-cisternography. Conservative therapy is applicable to small fistulas. In the case of the inefficiency of this method, surgical method is then applied to the defect closure. Purpose of the study: To evaluate the effectiveness of endoscopic endonasal approach in the CSF leak treatment. Materials and methods: For the period from 2008 to 2018 at the Pavlov First Saint Petersburg State Medical University, at the clinic of neurosurgery of the Kirov Medical Institute and the Medical Research Center Almazov, 38 patients with spontaneous nasal liquorrhea were treated. All patients underwent plastic surgery of the CSF fistula by endoscopic endonasal approach. Results: In 4 cases, there was a large defect requiring secondary surgical intervention 1-2 weeks after the initial operation. Conclusions: The use of auto tissues (muscle or fat) is the method of choice for repeated surgical plastics of the cerebrospinal fluid fistula or in the case of a large size defect.

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Section: Methodsmentioning

confidence: 99%

Transsphenoidal Endoscopic Approach in Treatment of Spontaneous Nasal CSF-leak

Karpishchenko¹,

Cherebillo²,

Vereshchagina³

et al. 2019

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“…В исследовании приняли участие пациенты, находившиеся на стационарном лечении в отделении гнойной хирургии ГБУЗ «НИИ-ККБ №1» г. Краснодара, с хроническими воспалительными заболеваниями температуре +37°C и центрифугированием для осаждения клеток. Для получения тромбогеля сначала активировали тромбоциты раствором CaCl 2 (соотношение 20:1) в чашке Петри для выделения аутологичного тромбина по описанной методике [20]. Затем интраоперационно смешивали в равных количествах тромбин и ОбТП в соотношении 1:1 до получения тромбогеля.…”

Section: материалы и методыunclassified

Platelet-rich plasma in the treatment of chronic inflammatory diseases of lower extremities

Гилевич

Валерьевна²,

Shubrov³

et al. 2021

Science and Innovations in Medicine

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Objectives to evaluate the effectivenes of platelet-rich plasma preparations in the treatment of chronic inflammatory diseases of lower extremities. Material and methods. The study involved patients hospitalized in the Research Institute S. V. Ochapovsky Regional Clinic Hospital No.1, Krasnodar, with trophic ulcers and chronic osteomyelitis. The patients received injections of platelet-rich plasma as platelet lysate and/or platelet gel. Results. The study involved 19 patients with trophic ulcers of the lower extremities with a duration of more than 2 months. Previously, the patients had underwent therapy without effect. In all cases, the patients received a complex of therapeutic measures, including debridement, dressing, conservative treatment, physiotherapy, antibiotic therapy. In the presence of large ulcers, 8 patients underwent autodermoplasty with complete engraftment. It has been noted that during platelet-rich plasma use the average healing time was 6-7 weeks. Four patients were observed with chronic osteomyelitis. During operation, the bone cavity was filled with platelet gel. The postoperative period was uneventful in all cases. The maximum observation period was 1.5 years. No recurrence of osteomyelitis was detected. Conclusion. The results of the study demonstrate the positive effects of platelet-rich plasma products use.

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“…There is a wide variety of methods for placing the grafts on DM defects: regular and seamless suturing, using gels and sealants etc. [52][53][54][55][56][57].…”

mentioning

confidence: 99%

Materials for Plastic Surgery of the Dura Mater: History and Current State of the Problem (Review)

Danilova¹,

Gorbunova²,

Tsybusov³

et al. 2018

Sovrem Tehnol Med

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The review addresses one of the important aspects of modern neurosurgery: the repair of various dura mater defects. The optimal material for plastic surgery of the dura mater should meet certain biological, physical and chemical requirements, should not cause serious complications such as liquorrhea, inflammation or brain's lining scars, it should be simple and convenient in use, as well as cost-effective. The present report reviews the concepts and techniques developed in the XIX-XX centuries and also describes the materials used at the present time such as autografts (from patient's own tissues), collagen, and synthetic materials both absorbable and non-absorbable. We analyze a number of domestic and internationally-known implants used in the dura mater plastic repair. The prospects of the new synthetic Russia-made material Reperen for the dura mater plastic surgery are discussed.

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The use of platelet gel for repair of a cerebrospinal fluid fistula of the skull base (a case report and literature review)

Cited by 5 publications

References 10 publications

Transsphenoidal Endoscopic Approach in Treatment of Spontaneous Nasal CSF-leak

Transsphenoidal Endoscopic Approach in Treatment of Spontaneous Nasal CSF-leak

Platelet-rich plasma in the treatment of chronic inflammatory diseases of lower extremities

Materials for Plastic Surgery of the Dura Mater: History and Current State of the Problem (Review)

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