The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion <i>via</i> IGF-1 and PAI-1

Daubriac, Julien; Han, Song; Grahovac, Jelena; Smith, Eve Y.; Hosein, Abdel; Buchanan, Marguerite; Basik, Mark; Boucher, Yves

doi:10.18632/oncotarget.23735

Cited by 37 publications

(24 citation statements)

References 54 publications

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“…In MSC-CA and MSC-DCIS, here we determined the decreased expression of GDF15 and IGF, but this conflicts with published results which show increased expression of these genes in the tumor micro-environment [34].…”

Section: Discussioncontrasting

confidence: 99%

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy

Plavá

Cihova

Buríková

et al. 2020

Cells

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During cancer progression, breast tumor cells interact with adjacent adipose tissue, which has been shown to be engaged in cancer aggressiveness. However, the tumor-directed changes in adipose tissue-resident stromal cells affected by the tumor–stroma communication are still poorly understood. The acquired changes might remain in the tissue even after tumor removal and may contribute to tumor relapse. We investigated functional properties (migratory capacity, expression and secretion profile) of mesenchymal stromal cells isolated from healthy (n = 9) and tumor-distant breast adipose tissue (n = 32). Cancer patient-derived mesenchymal stromal cells (MSCs) (MSC-CA) exhibited a significantly disarranged secretion profile and proliferation potential. Co-culture with MDA-MB-231, T47D and JIMT-1, representing different subtypes of breast cancer, was used to analyze the effect of MSCs on proliferation, invasion and tumorigenicity. The MSC-CA enhanced tumorigenicity and altered xenograft composition in immunodeficient mice. Histological analysis revealed collective cell invasion with a specific invasive front of EMT-positive tumor cells as well as invasion of cancer cells to the nerve-surrounding space. This study identifies that adipose tissue-derived mesenchymal stromal cells are primed and permanently altered by tumor presence in breast tissue and have the potential to increase tumor cell invasive ability through the activation of epithelial-to-mesenchymal transition in tumor cells.

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Section: Discussioncontrasting

confidence: 99%

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy

Plavá

Cihova

Buríková

et al. 2020

Cells

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“…The DEGs found in the dataset of GSE103512 were mainly involved in extracellular structure organization, reactive oxygen species metabolic process, glomerulus development, and regulation of nitric oxide biosynthetic process. There was no common GO term among three datasets, indicated that the BRCA was highly of heterogeneity, consistent with the previous study [15]. There was no same pathways among three datasets, consistent with the GO analysis and previous report [15].…”

Section: Discussionsupporting

confidence: 90%

“…There was no common GO term among three datasets, indicated that the BRCA was highly of heterogeneity, consistent with the previous study [15]. There was no same pathways among three datasets, consistent with the GO analysis and previous report [15].…”

Section: Discussionsupporting

confidence: 90%

“…There were no FDA drugs for IGFBP6, FOSB, and WLS. Further analysis showed that these three proteins interact with the well-known BRCA related proteins IGF1 [14][15][16] [14][15][16], FOS [17][18][19] [17][18][19],and WNT1 [20][21][22] [20][21][22], suggested that IGFBP6, FPSB, and FOS might be useful target for BRCA treatment. Survival analysis of the 7 DEGs…”

Section: Discussionmentioning

confidence: 99%

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Integrated bioinformatics analysis identifies core genes in breast cancer

Niu¹,

Zhang²,

Yu³

et al. 2019

Preprint

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Background Breast cancer (BRCA) is one of the most common malignancies in women. To reveal the molecular mechanism of the BRCA, the core genes associated with BRCA was studied by the integrated bioinformatics methods in the current study. Results A total of 1181 DEGs, 84 DEGs, and 190 DEGs were detected in GSE7904, GSE10797, and GSE103512, respectively. In addition, 7 hub genes overlapped from 3 datasets were selected, and ANNXA1, MYH11, IGFBP6, FOS, FOSB, KIT, and WLS might be the core genes of BRCA. The Go function analysis showed that the DEGs were enriched in chromosome segregation, gland development, leukocyte migration, extracellular structure organization and so on. The KEGG pathway analysis showed that the most DEGs were enriched in Pathways in cancer, Focal adhesion, ECM-receptor interaction, PPAR signaling pathway, etc. Additionally, ANXA1 was associated with worse overall survival, and the other 6 hub genes were associated with better overall survival. Conclusions ANNXA1, MYH11, IGFBP6, FOS, FOSB, KIT, and WLS might be the core genes of BRCA. WLS, IGFBP6, and FOSB might be a new biomarker of the breast tumor and potential new drug targets. This study provided new evidence for the future genomic individualized treatment of BRCA.

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“…Recently, cancer stroma has been reported to play important roles in proliferation and metastasis [ 80 , 81 ]. Factors secreted from cancer cells activate cells in the stroma, and then activated stromal cells stimulate cancer cells to proliferate and migrate [ 82 , 83 ]. Therefore, it might be possible to treat cancer by manipulating the cancer microenvironment [ 84 , 85 ].…”

Section: Efficiency Of Gene Therapy With Nonviral Vectorsmentioning

confidence: 99%

Nonviral Gene Therapy for Cancer: A Review

Hidai

Kitano

2018

Diseases

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Although the development of effective viral vectors put gene therapy on the road to commercialization, nonviral vectors show promise for practical use because of their relative safety and lower cost. A significant barrier to the use of nonviral vectors, however, is that they have not yet proven effective. This apparent lack of interest can be attributed to the problem of the low gene transfer efficiency associated with nonviral vectors. The efficiency of gene transfer via nonviral vectors has been reported to be 1/10th to 1/1000th that of viral vectors. Despite the fact that new gene transfer methods and nonviral vectors have been developed, no significant improvements in gene transfer efficiency have been achieved. Nevertheless, some notable progress has been made. In this review, we discuss studies that report good results using nonviral vectors in vivo in animal models, with a particular focus on studies aimed at in vivo gene therapy to treat cancer, as this disease has attracted the interest of researchers developing nonviral vectors. We describe the conditions in which nonviral vectors work more efficiently for gene therapy and discuss how the goals might differ for nonviral versus viral vector development and use.

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The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1

Cited by 37 publications

References 54 publications

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy

Integrated bioinformatics analysis identifies core genes in breast cancer

Nonviral Gene Therapy for Cancer: A Review

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