Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints—an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force

Filippou, Georgios; Scirè, Carlo Alberto; Adinolfi, Antonella; Damjanov, Nemanja; Carrara, Greta; Bruyn, G. A. W.; Cazenave, Tomás; D’Agostino, Maria; Sedie, Andrea Delle; Sabatino, V. Di; Cortés, Mario Enrique Díaz; Filippucci, Emilio; Gandjbakhch, Frédérique; Gutiérrez, Marwin; MacCarter, Daryl K.; Micu, Mihaela; Parera, Ingrid Möller; Mouterde, Gaël; Mortada, Mohamed; Naredo, Esperanza; Pineda, Carlos; Porta, Francesco; Reginato, Anthony M.; Satulu, Iulia; Schmidt, Wolfgang A.; Şerban, Teodora; Terslev, Lene; Vlad, Violeta; Vreju, F.; Zufferey, Pascal; Bozios, Panagiotis; Toscano, Carmela; Picerno, Valentina; Iagnocco, Annamaria

doi:10.1136/annrheumdis-2017-212542

Cited by 61 publications

(76 citation statements)

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“…CPP crystal deposits at the acetabular labrum fibrocartilage were identified as hyperechoic spots of variable shapes (i.e., rounded or amorphous‐shaped). CPP crystal deposits at the femoral head's hyaline cartilage were defined as a hyperechoic band (either focal or diffuse) within the cartilage layer . At the acetabular labrum fibrocartilage, only grades higher than 2 were considered positive according to the semiquantitative 0–3 scoring system proposed by Filippou et al (where 0 = absent, 1 = 1 to 2 spots, 2 = >2 spots covering <50% of the volume of the structure, and 3 = deposits covering >50% of the volume of the structure) .…”

Section: Methodsmentioning

confidence: 99%

Hip Involvement in Patients With Calcium Pyrophosphate Deposition Disease: Potential and Limits of Musculoskeletal Ultrasound

Matteo

Filippucci

Cipolletta

et al. 2019

Arthritis Care & Research

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Objective. To preliminarily explore the diagnostic potential of ultrasound (US) in detecting calcium pyrophosphate (CPP) crystal deposits at the hip joint in a cohort of patients with CPP deposition disease (CPPD) who were previously evaluated by conventional radiography (CR) and to assess the sensitivity and specificity as well as the agreement between US and CR in the evaluation of hip CPP crystal deposits.Methods. Fifty consecutive patients with definite CPPD and 40 age/sex/body mass index-matched disease control subjects who had undergone hip CR within the previous 6 months were enrolled. Bilateral hip US examination was carried out to assess the presence of CCP crystal deposits at the acetabular labrum fibrocartilage and at the femoral head's hyaline cartilage. Two independent radiologists evaluated the presence of hip CPP crystal deposits on CR in both groups.Results. US findings indicative of CPP crystal deposits were found in at least 1 hip in 45 of 50 patients with CPPD (90.0%) and in 73 of 100 hips (73.0%). CPP crystal deposits were more frequently found at the acetabular labrum fibrocartilage than at the femoral head's hyaline cartilage (72% and 17% of the hips in patients with CPPD, respectively).

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Section: Methodsmentioning

confidence: 99%

Hip Involvement in Patients With Calcium Pyrophosphate Deposition Disease: Potential and Limits of Musculoskeletal Ultrasound

Matteo

Filippucci

Cipolletta

et al. 2019

Arthritis Care & Research

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“…REFERENCES: [1] Background: 9The OMERACT Ultrasound (US) in calcium pyrophosphate deposition disease (CPPD) sub-task force has been working on the assessment of the utility of US in CPPD since 2014 first creating definitions for CPPD identification and then demonstrating that US is a reliable tool [1].…”

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“…We enrolled in this study consecutive patients waiting to undergo knee replacement surgery due to severe osteoarthritis. Each patient underwent US examination of the knee, focusing on the menisci and the hyaline cartilage, the day prior to surgery, scoring each site according to the presence/ absence of CPP as defined by OMERACT [1]. After surgery, the menisci and the condyles were collected and examined microscopically.…”

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Op0319 diagnostic Accuracy of Ultrasound in Calcium Pyrophosphate Deposition Disease: Preliminary Results of the Omeract Us in CPPD Sub-Group

et al. 2019

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Background9The OMERACT Ultrasound (US) in calcium pyrophosphate deposition disease (CPPD) sub-task force has been working on the assessment of the utility of US in CPPD since 2014 first creating definitions for CPPD identification and then demonstrating that US is a reliable tool[1].ObjectivesObjective of this study is to assess the diagnostic accuracy of US in CPPDMethodsThis is a multicentre international diagnostic accuracy study involving 17 centres from 9 countries. We enrolled in this study consecutive patients waiting to undergo knee replacement surgery due to severe osteoarthritis. Each patient underwent US examination of the knee, focusing on the menisci and the hyaline cartilage, the day prior to surgery, scoring each site according to the presence/absence of CPP as defined by OMERACT[1]. After surgery, the menisci and the condyles were collected and examined microscopically. Six samples were collected, both from the surface and from the internal part of menisci and cartilage trying to cover a large part of the structure. All slides were observed under transmitted light microscopy and by compensated polarised microscopy. A dichotomous score was given for the presence/absence of CPP crystals. US and microscopic analysis were performed by blinded operators. Sensitivity and specificity of US were calculated using microscopic findings of the menisci and cartilage as the gold standard.ResultsThese preliminary analyses include 30 patients. The mean age was 71yrs (SD±9.1), 19 (63%) were females. 17 patients were positive at US analysis and 12 at microscopic analysis. Diagnostic accuracy results of US at patient level, are presented in figure 1.ConclusionThese preliminary results demonstrate that US is a sensitive exam for identification of CPPD with acceptable specificity. US is the first diagnostic technique with consistent reliability and validity to be applied for non-invasive screening for CPPD in clinical practice.References[1] Filippou G, Scirè CA, Adinolfi A, et al. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints—an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force. Ann Rheum Dis 2018;:annrheumdis-2017-212542. doi:10.1136/annrheumdis-2017-212542Disclosure of InterestsGeorgios Filippou Speakers bureau: Laborest, Abbvie, BMS, Sanofi, Anna Scanu: None declared, Antonella Adinolfi: None declared, Carmela Toscano: None declared, Raquel Largo-Carazo: None declared, Esperanza Naredo Consultant for: Abbvie, Speakers bureau: AbbVie, Roche, Bristol-Myers Squibb, Pfizer, UCB, Lilly, Novartis, Janssen, and Celgene GmbH, Emilio Calvo: None declared, Gabriel Herrero-Beaumont: None declared, Pascal Zufferey: None declared, Christel Madelaine-Bonjour: None declared, Daryl MacCarter: None declared, Stanley Makman: None declared, Zachary Weber: None declared, Ingrid Möller: None declared, Marwin Gutierrez: None declared, Carlos Pineda: None declared, Denise C...

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“…The clinical spectrum of neuropsychyatric SLE is complex, includes 19 entities, focal or diffuse, with variable prevalences [16], and from those, cognitive dysfunction, depression and anxiety are relatively often observed, with an important input on patients prognosis and life quality. As noticed in any autoimmune disease, imaging methods, along with immunologic studies, enable an early diagnosis and individualized therapeutic measures [1,[17][18][19][20][21][22][23][24][25].…”

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Cognitive Dysfunction, Depression and Anxiety in a Cohort of Systemic Lupus Erythematosus Patients

Bărbulescu¹,

Sandu²,

Boldeanu³

et al. 2019

Rev. Chim.

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SLE is the prototype of connective tissue diseases that can present the complete spectrum of neurologic and psychiatric disorders, cognitive dysfunction, depression and anxiety being more prevalent compared to general population, with an input on patients� prognosis and quality of life. In this study we aimed to determine the presence of cognitive dysfunction, anxiety and depression in a cohort of SLE patients, and their relationship to disease activty and quality of life. We determined the presence of these neuropsychyatric manifestations in signfficant percentages, directly correlated to disease activity and with an impact of quality of life. Our results lead to its extension, with multicentric contribution, and underline the necessity and benefit of a careful and periodical neuropsychiatric examination, in order to recognize the clinical patterns in early stages, apply the proper therapeutic measures, quantify the future damage and improve the outcome of these patients.

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Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints—an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force

Cited by 61 publications

References 20 publications

Hip Involvement in Patients With Calcium Pyrophosphate Deposition Disease: Potential and Limits of Musculoskeletal Ultrasound

Hip Involvement in Patients With Calcium Pyrophosphate Deposition Disease: Potential and Limits of Musculoskeletal Ultrasound

Op0319 diagnostic Accuracy of Ultrasound in Calcium Pyrophosphate Deposition Disease: Preliminary Results of the Omeract Us in CPPD Sub-Group

Cognitive Dysfunction, Depression and Anxiety in a Cohort of Systemic Lupus Erythematosus Patients

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