Craniofacial structures' development in prenatal period: An MRI study

Begnoni, Giacomo; Serrao, Graziano; Musto, Federica; Pellegrini, G; Triulzi, Fabio; Dellavia, Claudia

doi:10.1111/ocr.12222

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Swallowing has been defined as a complex physiological act that occurs thousands of times per day and is fundamental for the development of the stomatognathic system . Hypothesis about the effects of tongue's variations in size, function and posture on the oral development and function and teeth position have been provided previously.…”

Section: Introductionmentioning

confidence: 99%

Electromyographic analysis of the oral phase of swallowing in subjects with and without atypical swallowing: A case‐control study

Begnoni

Llano-Pérula

Willems

et al. 2019

J of Oral Rehabilitation

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Background Swallowing is a complex physiologic function developing mostly in the first years of life. After 6 years old, if mature deglutition is not achieved, swallowing persists as “atypical swallowing” (AS). Objective The aim of this study was to detect any electromyographical differences in the muscular activation pattern in patients with and without AS. Materials and methods 38 adolescents and young adults were selected for this study: 20 with atypical swallowing (AS group) and 18 without (C group). Standardised surface electromyographic analysis was performed by the same operator to detect the activity of masseter (MM), temporalis (TA) and submental (SM) muscles. A Student t test for unpaired data was carried out to detect differences between the AS and C groups. A 1‐way ANOVA was performed to detect any differences between the three couples of muscles. Results When compared to controls, AS patients showed a significantly longer duration of activity for each couple of muscles and for the whole duration of swallowing act (P < 0.0001) as well as lower intensity of the SM activity (P < 0.05) than controls. Within the AS and C groups, masticatory muscles (MM and TA) showed lower duration of activation (P < 0.01) and lower intensity of the spike (P < 0.0001) than SM. Within the C group, masticatory muscles also reached their activation spike earlier (1‐way ANOVA, P < 0.01) than SM. Conclusion Two different muscular performance models have been defined: patients with AS showed a longer activity of all the muscles involved with a lower intensity of SM activity than that of controls.

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Section: Introductionmentioning

confidence: 99%

Electromyographic analysis of the oral phase of swallowing in subjects with and without atypical swallowing: A case‐control study

Begnoni

Llano-Pérula

Willems

et al. 2019

J of Oral Rehabilitation

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“…We have investigated the development of the SHR during a fairly long and important period of human development -from 7th to 12th weeks. It is during this period that complex processes of morphogenesis of the mandible and neck muscles, formation of definitive topographic-anatomical relationships take place, which is emphasized by other researchers in this area [1,3,10,11]. A characteristic feature of the development of suprahyoid muscular triangles of the neck is the uneven growth of their morphometric parameters, due to the different growth rates of the structures that limit it.…”

Section: Discussionmentioning

confidence: 97%

“…Finding out the features of morphogenesis and topographic changes of suprahyoid region (SHR) of the neck and its structures in the dynamics of human intrauterine development (IUD) remains a relevant area of morphological research [1][2][3][4][5]. Refined, comprehensive data on gender, age and constitutional features of the structure and topography of organs and structures of the SHR of the neck during the prenatal period of human ontogenesis will make it possible to develop new criteria for the interpretation of medical diagnostic imaging data, the degree of fetal viability, improve existing and develop new methods of surgical correction of congenital neck defects [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of the Morphometric Parameters of Suprahyoid Region of the Human Prefetuses

et al. 2021

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The aim: To determine the peculiarities of the morphometric parameters of suprahyoid region of the human prefetuses. Materials and methods: Thirty specimens of human prefetuses of 14.0-80.0 mm parietococcygeal length (PCL) (7-12 weeks of IUD) were studied using a complex of modern methods of morphological research. Results: On the basis of obtained digital indicators of the main morphometric parameters of human SHR in the dynamics of the prenatal period of IUD the critical periods of development of the region were clarified and mathematical functions that describe the normal course of organogenesis of SHR were created, which can be useful for creating diagnostic algorithms for the norm when carrying out prenatal diagnostics and monitoring the state of the fetus. It has been established that the 9-10th week of IUD is a critical period in the development of SHR, since during this time, intensive growth processes occur, which are manifested by a sharp change in the size of the organ, and this can lead to the appearance of variants of the structure and possible congenital defects of the SHR and the dental-maxillary apparatus in general. Conclusions: 1.Age-depended dynamics of changes in the anterior angle of the SHR shows an almost linear decrease in the angle by the end of the 9th week of IUD almost to 76°, after which it increases to almost 90° by the end of the 10th week. From the 11th week of the IUD, the anterior angle decreases again to 77 °, but begins to increase at the 12th week and by the end of the prefeal period. 2.The lateral length of SHR increases almost uniformly until the 9th week of IUD, during which its growth rate slows down. Starting from the end of the 10th week of IUD, this morphometric parameter begins to grow rapidly until the end of the prenatal period of ontogenesis. The growth rate of the lateral length of the SHR is described by the function: L lat = 1.1025 + 0.0015 x + 0.001 x2. 3.The width of the SHR from the 10th week of IUD begins to grow rapidly until the end of the prenatal period of development. The growth rate of the width of SHR is described by the function: W = 1.1025 + 0.0015 x + 0.001 x2. 4.Analysis of the age dynamics of the area of SHR demonstrates the exponential dependence on the age of the prefetuses, which is described by a mathematical function: A = 1,2452exp(0,0424x). Meanwhile, there is a slight slowdown in its growth rate at the 10th week of IUD with subsequent recovery of growth by the end of the prenatal period of ontogenesis. 5.The 9-10th week of IUD is a critical period in the development of SHR, since during this time, intensive growth processes occur, which are manifested by a sharp change in the size of the mandible.

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“…The anterior triangle of neck (AT) in human fetuses (81,0-310,0 mm PCL) is limited by the sternocleidomastoid muscle laterally (that already has developed into a mature muscular structure that spreads from the mastoid process to the clavicle), by the mandible superiorly and by the midline anteriorly (vertical line from the midpoint of the mandible that reaches the midpoint of the sternal incision). Specific feature of AT during fetal period of PND is the fact that it highly relies on bony boundaries such as mandible, sternum and clavicle that haven't reached their mature morphology at 3 rd month of PND ( Figure 1), which influences sized and topographical location of infrahyoid triangles (Begnoni et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Spatio-Temporal Morphological Changes of Structures in Infrahyoid Triangles in Human Fetuses During Fetal Period of Human Ontogenesis

2020

European Journal of Medicine

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Infrahyoid triangles in anterior region of neck contain crucial structures for human body like trachea, thyroid gland, nerve plexuses and magistral blood vessels. Infrahyoid muscle flaps are often used for reconstructive surgeries that is why the topography of their innervation is important for successful dissection and minimization of postsurgical complications. That is why the aim of our study was to examine topographical peculiarities of structures in infrahyoid triangles in human fetuses during late intrauterine prenatal development (PND) that would provide clinical practitioners like pediatric and oncologic surgeons with additional anatomic data. We have examined 18 specimens of human fetuses (4-9 th month of PND, 82,0-311,0 mm of parieto-coccigeal length (PCL)). All material was obtained and studied at Chernivtsy Regional Pathologists Office (Ukraine) in accordance with bilateral collaboration with the Department of Histology, Cytology and Embryology of BSMU. To reach the aim of the research we have used classic morphological methods (anthropometry, morphometry, layered dissection) as well as injection of the blood vessels (in 6 specimens by the means of dies) and three-dimensional reconstructioning. The study was performed in accordance with the provisions of the Declaration of Helsinki on ethical issues of studies conducted with humans (1964-2008). We have seen that in fetal period of human PND (80,0-310,0 mm of PCL) ansa cervicalis, that provides innervation for infrahyoid structures, is formed by anastomosis of the superior and inferior roots (C2 and C3) that are merging with internal carotid artery and internal jugular vein. The infrahyoid muscles receive nourishment predominantly from the superior thyroid artery, that is a branch of external carotid artery (91 %) or rarely bifurcation (3 %) and either as a branch of common carotid artery (6 %). Specific feature of infrahyoid triangles during fetal period of PND is the fact that it highly relies on bony boundaries such as mandible, sternum and clavicle that haven't reached their mature morphology at 3 rd month of PND. Investigations of topographical peculiarities of structures in infrahyoid triangles in fetal period of PND are important for successful reconstruction surgeries in postnatal and adult age.

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Craniofacial structures' development in prenatal period: An MRI study

Cited by 11 publications

References 18 publications

Electromyographic analysis of the oral phase of swallowing in subjects with and without atypical swallowing: A case‐control study

Electromyographic analysis of the oral phase of swallowing in subjects with and without atypical swallowing: A case‐control study

Peculiarities of the Morphometric Parameters of Suprahyoid Region of the Human Prefetuses

Spatio-Temporal Morphological Changes of Structures in Infrahyoid Triangles in Human Fetuses During Fetal Period of Human Ontogenesis

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