Chronic perinatal odour exposure with heptaldehyde affects odour sensitivity and olfactory system homeostasis in preweaning mice

Dewaele, Aurélie; Persuy, Marie‐Annick; Badonnel, Karine; Meunier, Nicolas; Durieux, Didier; Castille, Johan; Favreau-Peigné, Angélique; Baly, Christine

doi:10.1016/j.bbr.2018.02.026

Cited by 11 publications

(8 citation statements)

References 65 publications

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“…Here, we found that the increase in glomerular area induced by prolonged passive olfactory experience correlates with a rise in the intensity of the glomerular response (Figure 2). The increase in glomerular intensity upon olfactory experience has been previously reported (Dewaele et al, 2018;Inoue et al, 2021;Sachse et al, 2007;Woo et al, 2007) and might be related to the increase in the amount of arriving terminal axons from OSNs (Cadiou et al, 2014;Degano et al, 2014;Monjaraz-Fuentes et al, 2017) and/or a more efficient OSN transduction signal (Cadiou et al, 2014). Moreover, the increase in glomerular responses after olfactory experience can be also due to enhanced responses of glomerular interneurons (Sachse et al, 2007;Mandairon et al, 2008Mandairon et al, , 2018Zhou et al, 2016: Geramita & Urban, 2016Arenkiel et al, 2011;Degano et al, 2014) or more stable synaptic interactions within glomeruli (Livneh & Mizrahi, 2011).…”

Section: Discussionmentioning

confidence: 68%

Main olfactory bulb reconfiguration by prolonged passive olfactory experience correlates with increased brain‐derived neurotrophic factor and improved innate olfaction

Hernández-Soto

Pimentel-Farfan

Elva

et al. 2022

Eur J of Neuroscience

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The main olfactory bulb (MOB) is highly plastic and constantly reconfiguring its function and structure depending on sensory experience. Despite the extensive evidence of anatomical, functional and behavioural changes in the olfactory system induced by highly variable olfactory experiences, it is still unknown whether prolonged passive odour experience could reconfigure the MOB at its input and network activity levels and whether these changes impact innate olfaction. Here, by measuring odour-induced glomerular activation, MOB network activity and innate olfactory behaviours, we described a profound MOB reconfiguration induced by prolonged passive olfactory experience in adult animals that impacts MOB input integration at the glomerular layer including an increase in the activated glomerular area and signal intensity, which is combined with a refinement in the number of activated glomeruli and less-overlapped glomerular maps. We also found that prolonged passive olfactory experience dramatically changes MOB population activity in the presence and absence of odours, which is reflected as a decrease in slow oscillations (<12 Hz) and an increase in fast oscillations (>12 Hz). All these functional changes in awake and anaesthetized mice correlate with an increase in brain-derived neurotrophic factor (BDNF) and with improved innate olfactory responses such as habituation/dishabituation and innate preference/avoidance. Our study shows that prolonged passive olfactory experience in adult animals produces a dramatic reconfiguration of the MOB network, possibly driven by BDNF, that improves innate olfactory responses.

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Section: Discussionmentioning

confidence: 68%

Main olfactory bulb reconfiguration by prolonged passive olfactory experience correlates with increased brain‐derived neurotrophic factor and improved innate olfaction

Hernández-Soto

Pimentel-Farfan

Elva

et al. 2022

Eur J of Neuroscience

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“…Focusing just on the olfactory epithelium, 20 days of continuous or "pulsed" odorant exposure caused mice to display decreased EOG responses, compared to controls, that were specific to the enrichment odor [37]. Consistent with this finding, feeding mouse dams heptaldehyde-laden food throughout gestation and the preweaning period also leads to a reduction in the magnitude of their pups' EOG responses to that odor as well as a reduction in transcripts of a heptaldehyde-sensitive olfactory receptor [38]. Still other investigators have found no effect of postnatal odor enrichment on EOG responses despite observing a decrease in the density of OSN subtypes expressing the olfactory receptors for which the enriched odor was the ligand [39].…”

Section: Plos Onementioning

confidence: 61%

The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs

Blount

Coppola

2020

PLoS ONE

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Intelligent systems in nature like the mammalian nervous system benefit from adaptable inputs that can tailor response profiles to their environment that varies in time and space. Study of such plasticity, in all its manifestations, forms a pillar of classical and modern neuroscience. This study is concerned with a novel form of plasticity in the olfactory system referred to as induction. In this process, subjects unable to smell a particular odor, or unable to differentiate similar odors, gain these abilities through mere exposure to the odor(s) over time without the need for attention or feedback (reward or punishment). However, few studies of induction have rigorously documented changes in olfactory threshold for the odor(s) used for "enrichment." We trained 36 CD-1 mice in an operant-olfactometer (go/no go task) to discriminate a mixture of stereoisomers from a lone stereoisomer using two enantiomeric pairs: limonene and carvone. We also measured each subject's ability to detect one of the stereoisomers of each odor. In order to assess the effect of odor enrichment on enantiomer discrimination and detection, mice were exposed to both stereoisomers of limonene or carvone for 2 to 12 weeks. Enrichment was effected by adulterating a subject's food (passive enrichment) with one pair of enantiomers or by exposing a subject to the enantiomers in daily operant discrimination testing (active enrichment). We found that neither form of enrichment altered discrimination nor detection. And this result pertained using either within-subject or between-subject experimental designs. Unexpectedly, our threshold measurements were among the lowest ever recorded for any species, which we attributed to the relatively greater amount of practice (task replication) we allowed our mice compared to other reports. Interestingly, discrimination thresholds were no greater (limonene) or only modestly greater (carvone) from detection thresholds suggesting chiral-specific olfactory receptors determine thresholds for these compounds. The super-sensitivity of mice, shown in this study, to the limonene and carvone enantiomers, compared to the much lesser acuity of humans for these compounds, reported elsewhere, may resolve the mystery of why the former group with four-fold more olfactory receptors have tended, in previous studies, to have similar thresholds to the latter group. Finally, our results are consistent with the conclusion that supervised-perceptual learning i.e. that involving repeated feedback for correct and incorrect decisions, rather than induction, is the form of plasticity that allows animals to fully realize the capabilities of their olfactory system.

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“…These results contrast with other studies using other periods of exposure. Adding the odorant heptanal to the maternal food, during gestation then lactation specifically decreased the electrophysiological response of pup OSN to it (Dewaele et al 2018). Other studies using an exposure limited to the postnatal period showed no effect on the OSN population (Kerr and Belluscio 2006;Monjaraz-Fuentes et al 2017).…”

Section: Olfactory Learning and Osn Plasticitymentioning

confidence: 87%

Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system

2021

Self Cite

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Detection and discrimination of odorants by the olfactory system plays a pivotal role in animal survival. Olfactory-based behaviors must be adapted to an ever-changing environment. Part of these adaptations includes changes of odorant detection by olfactory sensory neurons localized in the olfactory epithelium. It is now well established that internal signals such as hormones, neurotransmitters, or paracrine signals directly affect the electric activity of olfactory neurons. Furthermore, recent data have shown that activity-dependent survival of olfactory neurons is important in the olfactory epithelium. Finally, as olfactory neurons are directly exposed to environmental toxicants and pathogens, the olfactory epithelium also interacts closely with the immune system leading to neuroimmune modulations. Here, we review how detection of odorants can be modulated in the vertebrate olfactory epithelium. We choose to focus on three cellular types of the olfactory epithelium (the olfactory sensory neuron, the sustentacular and microvillar cells) to present the diversity of modulation of the detection of odorant in the olfactory epithelium. We also present some of the growing literature on the importance of immune cells in the functioning of the olfactory epithelium, although their impact on odorant detection is only just beginning to be unravelled.

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Chronic perinatal odour exposure with heptaldehyde affects odour sensitivity and olfactory system homeostasis in preweaning mice

Cited by 11 publications

References 65 publications

Main olfactory bulb reconfiguration by prolonged passive olfactory experience correlates with increased brain‐derived neurotrophic factor and improved innate olfaction

Main olfactory bulb reconfiguration by prolonged passive olfactory experience correlates with increased brain‐derived neurotrophic factor and improved innate olfaction

The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs

Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system

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