RETRACTED: Long non-coding RNA TUG1 inhibits apoptosis and inflammatory response in LPS-treated H9c2 cells by down-regulation of miR-29b

Zhang, Haifang; Li, Hui; Ge, Ang; Guo, Enyu; Liu, Shuxia; Zhang, Lijuan

doi:10.1016/j.biopha.2018.02.129

Cited by 64 publications

(44 citation statements)

References 36 publications

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“…15 Recent studies corroborated that TauCl and TUG1 have anti-inflammatory impacts. 15,16 Outside of this, Zhang et al 17 uncovered that TUG1 could mediate cell proliferation in non-small-cell long cancer (NSCLC). Whereas whether TUG1 affects the pathogenesis of pneumonia remains uninvestigated.…”

Section: Introductionmentioning

confidence: 99%

Retracted: Protective impacts of long noncoding RNA taurine‐upregulated 1 against lipopolysaccharide‐evoked injury in MRC‐5 cells through inhibition of microRNA‐127

Meng¹,

Chen²,

Zhang³

2019

J of Cellular Biochemistry

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Background Pneumonia is a respiratory disease, which is triggered by pathogenic microorganisms or physical/chemical factors. Increasing evidence confirmed the vital impacts of long noncoding RNAs on various inflammatory diseases. Nonetheless, the influence of taurine‐upregulated 1 (TUG1) in pneumonia remains vague. The research tried to disclose the protective impacts of TUG1 against lipopolysaccharide (LPS)‐evoked injury in MRC‐5 cells. Methods MRC‐5 cells were disposed with LPS to construct pulmonary injury model. Then, pc‐TUG1 vector was transfected into MRC‐5 cells and the influence of overexpressed TUG1 in cell viability, apoptosis, and pro‐inflammatory cytokines in LPS‐disposed cells were evaluated. The correlation between TUG1 and microRNA (miR)−127 was estimated via utilizing real‐time quantitative polymerase chain reaction (RT‐qPCR), meanwhile whether miR‐127 affected the impacts of TUG1 on LPS‐injured MRC‐5 cells was explored. Besides, NF‐κB and p38MAPK pathways were evaluated to understand the dormant mechanisms. Results LPS administration apparently evoked inflammatory injury in MRC‐5 cells by restraining cell viability, accelerating apoptosis, and enhancing TNF‐α and IL‐6 productions. But, TUG1 lightened LPS‐evoked pro‐inflammatory response in MRC‐5 cells. In addition, miR‐127 was repressed by overexpressed TUG1, meanwhile the protective impacts of TUG1 against LPS‐evoked inflammatory injury in MRC‐5 cells were overturned by overexpressed miR‐127. Finally, we disclosed that TUG1 hindered the activation of NF‐κB and p38MAPK pathways via restraining miR‐127. Conclusions These explorations testified that taurine‐upregulated 1 (TUG1) protected MRC‐5 cells against lipopolysaccharide (LPS)‐evoked inflammatory injury via hindering miR‐127/NF‐κB/p38MAPK axis.

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Section: Introductionmentioning

confidence: 99%

Retracted: Protective impacts of long noncoding RNA taurine‐upregulated 1 against lipopolysaccharide‐evoked injury in MRC‐5 cells through inhibition of microRNA‐127

Meng¹,

Chen²,

Zhang³

2019

J of Cellular Biochemistry

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“…Moreover, the expression of TUG1 was found to be negatively correlated with disease duration and SLEDAI score in our study, 20 Liang Z et al also reported that up-regulation of TUG1 attenuated the apoptosis and inflammation induced by LPS in ATDC5 cells. 30 All these studies indicated that TUG1 might be associated with inflammation and renal injury in SLE pathogenesis.…”

Section: Discussionsupporting

confidence: 72%

“…Similarly, reduced expression of TUG1 has also been found in patients with diabetic nephropathy, with TUG1 being able to ameliorate the bioenergetics of the mitochondria of Sertoli cells in diabetic mice . Furthermore, TUG1 was down‐regulated in LPS‐induced injury of myocardial cells, whereas overexpression of TUG1 could be able to mitigate that injury, increasing cell viability and suppressing the expression of inflammatory cytokines . PBMC subpopulations, including T‐cells, B‐cells and neutrophils, are involved in the pathogenesis of SLE, with cytokines, signaling molecules and pattern‐recognition receptors expressed on a considerable scale as the pathological process of SLE progresses .…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, the correlation between the expression of TUG1 and inflammatory markers was analyzed, and the results showed that TUG1 expression was inversely related to ESR and 24‐hour urinary protein. Zhang et al found that TUG1 could inhibit apoptosis and inflammatory injury in LPS‐treated H9c2 cells by down‐regulation of miR‐29b . Liang Z et al also reported that up‐regulation of TUG1 attenuated the apoptosis and inflammation induced by LPS in ATDC5 cells .…”

Section: Discussionmentioning

confidence: 99%

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Clinical significance of reduced expression of lncRNA TUG1 in the peripheral blood of systemic lupus erythematosus patients

Cao

Wang

et al. 2020

Int J of Rheum Dis

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Objective To investigate the expression and clinical significance of long non‐coding RNA taurine up‐regulated gene 1 (lncRNA TUG1) in the peripheral blood of systemic lupus erythematosus (SLE) patients. Methods With the peripheral blood mononuclear cells (PBMCs: T‐cells, B‐cells and monocytes) collected from SLE patients and healthy controls, TUG1 expression was determined to identify the correlation with the clinicopathological features of SLE patients. Thereby, the diagnostic value of TUG1 expression in diagnosis of SLE was evaluated by receiver operating characteristic (ROC) curve analysis. Results As compared to healthy controls, SLE patients manifested a lower expression of TUG1 in PBMCs, which was further decreased in SLE patients with lupus nephritis (P < .05). The lowest level of TUG1 was found in monocytes, rather than T‐cells or B‐cells (P < .05). Negative correlations were identified between TUG1 levels and SLE Disease Activity Index score (r = −.904, P < .001), erythrocyte sedimentation rate (r = −.779, P < .001), disease duration (r = −.503, P < .001) and 24‐hour urinary protein (r = −.807, P < .001). Complement C3 levels were positively associated with TUG1 expression (r = .817, P < .001). In addition, the area under the ROC curve of diagnostic efficiency for SLE based on TUG1 was 0.982, and 0.930 for SLE with lupus nephritis. Conclusions The levels of lncRNA TUG1 was markedly lower in the SLE patients, which was more obvious in SLE patients with lupus nephritis, and thus, it could be a promising clinical diagnostic tool for SLE patients or SLE patients with lupus nephritis.

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“…Zhang et al reported that TUG1 played an anti-apoptotic role in lipopolysaccharide-treated H9c2 cells. 23 In this study, we found that the TUG1 expression was enhanced in the H9c2 cells aer incubation in 1% O 2 for 24 h. Furthermore, silencing of TUG1 exacerbated the hypoxia-induced inhibition of viability and increase of apoptosis in the H9c2 cells, suggesting that TUG1 might exert a myocardial protective function via antiapoptosis of myocardial cells; this was in agreement with the results of the previous study conducted by Jiang 10 We hypothesized that different hypoxic stresses might induce different microenvironments in hypoxia-challenged H9c2 cells, leading to an alteration of the TUG1 function, which could be explored through the H9c2 cell model under different hypoxic stresses in the future. LncRNA plays its role by regulating the abundance of miRNAs.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: Knockdown of TUG1 aggravates hypoxia-induced myocardial cell injuryviaregulation of miR-144-3p/Notch1

Zhu

Xia

et al. 2019

RSC Adv.

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RETRACTED: Long non-coding RNA TUG1 inhibits apoptosis and inflammatory response in LPS-treated H9c2 cells by down-regulation of miR-29b

Cited by 64 publications

References 36 publications

Retracted: Protective impacts of long noncoding RNA taurine‐upregulated 1 against lipopolysaccharide‐evoked injury in MRC‐5 cells through inhibition of microRNA‐127

Retracted: Protective impacts of long noncoding RNA taurine‐upregulated 1 against lipopolysaccharide‐evoked injury in MRC‐5 cells through inhibition of microRNA‐127

Clinical significance of reduced expression of lncRNA TUG1 in the peripheral blood of systemic lupus erythematosus patients

Retracted Article: Knockdown of TUG1 aggravates hypoxia-induced myocardial cell injuryviaregulation of miR-144-3p/Notch1

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