Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

Abstract

BackgroundLarge scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.MethodsThe articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.ResultsThe significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001).ConclusionThe meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.Electronic supplementary materialThe online version of this article (10.1186/s12881-018-0553-5) contains supplementary material, which is available to authorized users.

Transcription Factor 7-Like-2 (<b><i>TCF7L2</i></b>) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

“…Anjum et al [16] in Chinese population, Danquah et al [17] in Ghanaian population, Ezzidi et al [18] in Tunisian population, and Assmann et al [19] in Brazilian population came to the same conclusion of the significance of association of the TCF7L2 rs7903146 (C/T) polymorphism and T2DM susceptibility, especially the homozygous TT genotype. A meta-analysis conducted by Lou et al [20] on subjects from different ethnic groups showed a positive correlation of the rs7903146 C/T SNP with T2DM, and this agrees with a previous meta-analysis made by Ding et al [21].…”

SNP-Based Genetic Risk Score Modeling Suggests No Increased Genetic Susceptibility of the Roma Population to Type 2 Diabetes Mellitus

“…As reported by the International Diabetes Federation, diabetes currently affects over 425 million people worldwide, and by 2045, this will rise to 625 million [62]. Type 2 diabetes accounts for at least 90% of diabetes, and its prevalence is rapidly growing, especially in low and middle income countries [45]. Studies show that not only the prevalence, but also the onset of diabetes strongly varies among ethnic groups [68,69].…”

Genetic associations between Transcription Factor 7 Like 2 rs7903146 polymorphism and type 2 diabetes mellitus: a meta-analysis of 115,809 subjects

“…Since then, many genetic association studies were performed in diverse populations to estimate potential associations between TCF7L2 rs7903146 polymorphism and T2DM, with inconsistent results. In 2018, Ding et al [9] already performed a meta-analysis to assess association between TCF7L2 rs7903146 polymorphism and T2DM, but only 28 studies were included by the authors and many eligible studies were missed. Therefore, we conducted an updated meta-analysis of all relevant studies published before May 2019 to more comprehensively analyze the effects of TCF7L2 rs7903146 polymorphism on individual susceptibility to T2DM in a larger pooled population.…”